Study the Role of Selenium or Zinc as Organic form on some Antioxidant and Liver Enzymes of Rams

Abstract Background:The liver is the second most injured organ following blunt abdominal trauma (BAT) after spleen. Although the computed tomography (CT) scan is considered as the gold standard for diagnosing liver injury in BAT, it is not readily available in the hospital. This study was performed to evaluate the role of aspartate transaminase (AST) and alanine transaminase (ALT) in patients with BAT and its significance in predicting the diagnosis and severity of the liver injury.Method:The study was conducted in Chitwan Medical College Teaching Hospital (CMCTH) study from February 2019 to May 2020. During that period 96 patients with BAT presented to the emergency department(ED) of CMCTH.Results:Among the 96 patients admitted with BAT, 38 patients had liver injury and 58 patients had no liver injury. The median length of the intensive care unit (ICU) stay of patients with liver injury was higher than without liver injury. There was a significant difference in the median level of AST and ALT (<0.001) between patients with liver injury and no liver injury. The area under the ROC curve of AST was 0.89(95% Confidence Interval 0.86-0.98) and of ALT was 0.92(95% Confidence Interval 0.83-0.97). The area under the curve demonstrated that the test was a good predictor for the identification of liver injury and also the severity of liver enzymes. The cut-off values for the liver injury were 106 U/l and 80 U/l for AST and ALT respectively. Based on these values, AST ≥ 106 U/l had a sensitivity of 71.7 %, a specificity of 90 %, a positive predictive value of 86.8 %, and a negative predictive value of 77.6 %. The corresponding values for ALT ≥ 80 U/l were 77.8 %, 94.1%, 92.1% and 82.8 %, respectively.ConclusionIn conclusion, we report the optimal cut-off value of AST and ALT for liver injury in BAT as ≥ 106 U/l and 80 U/l respectively. The elevated level of AST and ALT might assist the surgeons to timely refer the suspected patients with the liver to a tertiary center and it might help the surgeons to go for conservative management for minor liver injuries in BAT preventing the exposure hazards of the CT scan.

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The role of physical activity on blood factors, lipid profile, and liver enzymes of tile factory workers (A Case Study)

Occupational Medicine ◽

10.18502/tkj.v12i2.4373 ◽

2020 ◽

Author(s):

MH Dashti khavidaki ◽

AA Minaeifar ◽

F Rassekh ◽

A Baghiani

Keyword(s):

Physical Activity ◽

Lipid Profile ◽

Liver Enzymes ◽

Venous Blood ◽

Dust Particles ◽

Factory Workers ◽

Cross Sectional ◽

Tile Factory ◽

Blood Factors

Introduction: Inhalation of dust particles is prone to chronic diseases, and regular exercise reduces the risk of cardiovascular disease and improves blood variables. The purpose of this study was to investigate the role of physical activity on blood factors, lipid profile, and liver enzymes in tile factory workers. Materials and Methods: This is a cross-sectional study. 70 workers who were eligible to participate in the study were selected based on the sampling method available at the workplace. According to the Beck questionnaire, 15 people were included in each active and inactive groups. After 12 hours of worker's last meal, 10 ml of venous blood was used to evaluate biochemical variables of Blood factors (RBC, Hematocrit, Hemoglobin, WBC), lipid profile (Cholesterol, Triglyceride). Liver enzyme (ALT, AST, ALP) tests of both groups were performed in the occupational medicine laboratory of Meybod city, and SPSS Ver.23 software was used for analysis. Results: The results showed that red blood cells (p = 0.003) and hemoglobin (p = 0.034) in the active group were significantly higher than the inactive group. Also triglyceride (p = 0.025) and cholesterol (p = 0.042) of liver enzymes, (p = 0.011) ALT and AST (p = 0.047) were significantly lower. Conclusion: It seems that physical activity can have a positive effect; it can improve blood factors, liver enzymes, and fat profile in workers. According to the results, tile factory workers can achieve the desired blood factors with minimal physical activity.

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Role of interleukin 6 in liver cell regeneration after hemi-hepatectomy, correlation with liver enzymes and flow cytometric study

Clinical and Experimental Hepatology ◽

10.5114/ceh.2020.93055 ◽

2020 ◽

Vol 6 (1) ◽

pp. 42-48

Author(s):

Thamer Al-Ghamdi ◽

Ihab Atta ◽

Mohamed El-Refaei

Keyword(s):

Liver Cell ◽

Interleukin 6 ◽

Liver Enzymes ◽

Cell Regeneration ◽

Flow Cytometric ◽

Flow Cytometric Study

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Role of occult hepatitis B virus in chronic hepatitis C patients with flare of liver enzymes

European Journal of Internal Medicine ◽

10.1016/j.ejim.2010.12.001 ◽

2011 ◽

Vol 22 (2) ◽

pp. 187-190 ◽

Cited By ~ 15

Author(s):

Heba S. Selim ◽

Hadia A. Abou-Donia ◽

Hossam A. Taha ◽

Gasser I. El Azab ◽

Ahmed F. Bakry

Keyword(s):

Chronic Hepatitis ◽

Hepatitis C ◽

Hepatitis B Virus ◽

Hepatitis B ◽

Liver Enzymes ◽

Occult Hepatitis ◽

B Virus ◽

Occult Hepatitis B ◽

Chronic Hepatitis C Patients

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The Hydroxylation of Vitamin D on C25 in Thyrotoxicosis The Role of the Activity of Microsomal Liver Enzymes

International Journal of Clinical Medicine ◽

10.4236/ijcm.2012.34057 ◽

2012 ◽

Vol 03 (04) ◽

pp. 295-299 ◽

Cited By ~ 1

Author(s):

Chris G. Velentzas

Keyword(s):

Vitamin D ◽

Liver Enzymes ◽

Microsomal Liver

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ROLE OF HYPERBILIRUBINEMIA IN PREDICTON OF GANGRENOUS/PERFORATED APPENDICITIS

International Journal of Medical and Biomedical Studies ◽

10.32553/ijmbs.v5i7.2011 ◽

2021 ◽

Vol 5 (7) ◽

Author(s):

Irfan Hussain Khan ◽

Arun Bhargava

Keyword(s):

Acute Appendicitis ◽

Prospective Study ◽

Bilirubin Level ◽

Diagnostic Tool ◽

Liver Enzymes ◽

Serum Bilirubin ◽

Perforated Appendicitis ◽

Total Serum Bilirubin ◽

Total Serum

Introduction: The aim of this study was to determine the role of hyperbilirubinemia as a new diagnostic tool for predictor of gangrenous / perforated appendicitis. Methods: Hospital based prospective study was conducted on 100 patients with perforated/gangrenous appendix Results: In acute appendicitis case out of 84 cases 26 cases bilirubin level was more than 1mg/dl, in gangrenous appendicitis out of 3 cases all cases bilirubin level was more than 1mg/dl and in perforated appendicitis out of 13 cases 12 cases bilirubin level was more than 1mg/dl Conclusion: It is concluded from present study that elevated total serum bilirubin without elevation of liver enzymes is a good indicator of appendicular perforation. Keywords: Perforation, Appendicitis, Bilirubin

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Phase II trial with carboplatin/gemcitabine induction chemotherapy followed by radiotherapy concomitantly with paclitaxel/gemcitabine in stage III non-small cell lung cancer (NSCLC)

Journal of Clinical Oncology ◽

10.1200/jco.2006.24.18_suppl.7139 ◽

2006 ◽

Vol 24 (18_suppl) ◽

pp. 7139-7139 ◽

Cited By ~ 1

Author(s):

V. Hirsh ◽

M. Duclos ◽

L. Souhami ◽

P. Del Vecchio ◽

L. Ofiara ◽

...

Keyword(s):

Progressive Disease ◽

Liver Enzymes ◽

Phase Ii Trial ◽

Stage Iii ◽

Stage Iii Nsclc ◽

Grade 3 ◽

One Year ◽

Ecog Ps

7139 Background: The optimal combination of concomitant thoracic radiotherapy (TRT) and CT in stage III unresectable NSCLC remains unclear. The role of induction CT with Cb/G regimen, less toxic than Cisplatin/G, has not been established in stage III NSCLC. Methods: Forty-two patients (pts), 41 evaluable, entered this trial between January 2003 and November 2004, 27 males, 14 females, median age 60 (37–70), 19 pts with ECOG PS 0, 22 pts with PS 1, 22 pts with stage III A (N2), and 19 pts with stage III B (N2, N3). They received Cb AUC 5 i.v. on day 1 and G 1000 mg/m2 i.v. on days 1 + 8 every three weeks x 2 cycles, followed on day 50 by TRT, 60 Gy over 6 weeks, concomitantly with P 50 mg/m2 i.v. and G 100 mg/m2 i.v. on days 1 + 8 every three weeks x 2 cycles. Results: After induction CT, partial response (PR) was 73.1% (30 pts), stable disease (SD) 24.4% (10 pts), and 2.5% (1 pt) had progressive disease. After TRT and P/G, 19.5% (8 pts) had CR, 75.6% (31 pts) PR, and 4.9% (2 pts) PD. Median time-to-disease progression was 11.5 months. Median survival has not been reached yet, but surpassed 16.5 months; one-year survival is 71% (29 pts). Twenty three patients are still alive, after minimal follow-up of 13 months. First site of PD was in lungs in 7 pts, in brain 5 pts, in bones 4 pts; 2 pts died without PD, of cardiovascular disease. Toxicity of induction CT was minimal. During TRT and CT, grade 3 neutropenia, thrombocytopenia, and anemia occurred in 8 pts, 3 pts, and 3 pts respectively, grade 4 neutropenia and thrombocytopenia in one pt each. Nine pts received red cell transfusions, one pt platelet transfusion. One patient developed esophageal fistula with grade 4 toxicity, 3 pts had grade 3 esophagitis, 2 pts grade 3 infections, and one pt grade 3 dermatitis and elevation of liver enzymes. Conclusions: This regimen is effective, well tolerated, and appears to be an excellent choice for stage III NSCLC. Sponsored by Eli Lilly Canada. [Table: see text]

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