scholarly journals The Relationship between Inner Ear Disease and the Presence of Immune Complex

1993 ◽  
Vol 52 (Suppl-9) ◽  
pp. 55-59
Author(s):  
Tamotsu Harada ◽  
Takeshi Kubo ◽  
Toru Matsunaga
Keyword(s):  
Inner Ear ◽  
Immune Complex ◽  
Inner Ear Disease ◽  
The Relationship

Mechanism of Immune Complex—Mediated Inner Ear Diseases

1992 ◽  
Vol 101 (10_suppl) ◽  
pp. 72-77 ◽  
Author(s):  
Tamotsu Harada ◽  
Mitsuhito Sano ◽  
Satoshi Ogino ◽  
Masafumi Sakagami ◽  
Toru Matsunaga
Keyword(s):  
Inner Ear ◽  
Endolymphatic Hydrops ◽  
Stria Vascularis ◽  
Capillary Endothelium ◽  
Tracer Method ◽  
Ear Diseases ◽  
Inner Ear Disease ◽  
Foot Pad ◽  
The Relationship ◽  
Ig G

Tissues of the stria vascularis of normal rabbits were collected as cochlear antigen and injected into the foot pad of guinea pigs. The mechanism of development of endolymphatic hydrops was studied by the tracer method. Damage to the capillary endothelium and an increase in vascular permeability were found in the stria vascularis. Therefore, we studied patients with a raised level of immunoglobulin (Ig) G—class circulating immune complexes (CICs). Hearing loss was found in 3 of 22 patients with significantly elevated IgG CIC levels (13.6%). The relationship between inner ear disease and the presence of CIC was considered to be very significant. The possible mechanism of CIC-mediated inner ear diseases is discussed.

Protein profile of human perilymph: In search of markers for the diagnosis of perilymph fistula and other inner ear disease

1994 ◽  
Vol 111 (3) ◽  
pp. 273-280 ◽  
Author(s):  
I THALMANN ◽  
R KOHUT ◽  
J RYU ◽  
T COMEGYS ◽  
M SENARITA ◽  
...  
Keyword(s):  
Inner Ear ◽  
Protein Profile ◽  
Inner Ear Disease

The pathogenesis of the secondary forms of autoimmune inner ear disease (AIED): advancing beyond the audiogram data

2021 ◽  
Author(s):  
Virginia Corazzi ◽  
Stavros Hatzopoulos ◽  
Chiara Bianchini ◽  
Magdalena B Skarżyńska ◽  
Stefano Pelucchi ◽  
...  
Keyword(s):  
Inner Ear ◽  
Inner Ear Disease ◽  
Autoimmune Inner Ear Disease

Immunology of the inner ear: Response of the inner ear to antigen challenge

1983 ◽  
Vol 91 (1) ◽  
pp. 18-23 ◽  
Author(s):  
Jeffrey P. Harris
Keyword(s):  
Inner Ear ◽  
Blood Brain Barrier ◽  
Guinea Pigs ◽  
Keyhole Limpet Hemocyanin ◽  
Host Immunity ◽  
Brain Barrier ◽  
Antigen Challenge ◽  
Antibody Titers ◽  
Relationship Of ◽  
The Relationship

The relationship of the inner ear to host immunity and the immunoresponsiveness of the inner ear to antigen challenge were investigated. A radioimmunoassay was used to quantitate antibody titers to keyhole-limpet hemocyanin generated in the serum, perilymph, and CSF of guinea pigs following systemic or inner ear immunizations. The results of these experiments demonstrate (1) the blood-labyrinth barrier is analogous to the blood-brain barrier with respect to immunoglobulin equilibrium, (2) the inner ear is capable of responding to antigen challenge, and (3) the inner ear is an effective route for systemic immunization.

Immune-mediated inner ear disease

2000 ◽  
Vol 12 (1) ◽  
pp. 32-40 ◽  
Author(s):  
John H. Stone ◽  
Howard W. Francis
Keyword(s):  
Inner Ear ◽  
Immune Mediated ◽  
Inner Ear Disease

Cochlear Implantation Outcomes in Patients With Autoimmune and Immune-Mediated Inner Ear Disease

2010 ◽  
Vol 31 (8) ◽  
pp. 1337-1342 ◽  
Author(s):  
Saba Aftab ◽  
Maroun T. Semaan ◽  
Gail S. Murray ◽  
Cliff A. Megerian
Keyword(s):  
Inner Ear ◽  
Cochlear Implantation ◽  
Immune Mediated ◽  
Inner Ear Disease

Azathioprine in Combination with Steroids in the Treatment of Autoimmune Inner-Ear Disease

1993 ◽  
Vol 21 (4) ◽  
pp. 192-196 ◽  
Author(s):  
Aytac Saraçaydin ◽  
Sedat Katircioğlu ◽  
Sami Katircioğlu ◽  
M Can Karatay
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Inner Ear ◽  
Sensorineural Deafness ◽  
Sensorineural Hearing ◽  
Once Daily ◽  
Uncommon Disease ◽  
Inner Ear Disease ◽  
Pure Tones ◽  
Autoimmune Inner Ear Disease

A total of twelve patients with a relatively uncommon form of progressive sensorineural deafness (autoimmune innerear disease) were treated orally with 1 mg/kg azathioprine, once daily, and with 30 mg prednisolone, every other day, for 4 weeks. Statistically significant increases in the ability to hear pure tones or in discrimination on audiometry took place in 10/12 patients. This condition was initially described as ‘sensorineural hearing loss', but it is now clear that the term ‘autoimmune inner-ear disease’ is more appropriate since the vestibular compartment as well as the cochlear compartment is involved. This relatively uncommon disease is one of the few forms of sensorineural deafness that can be successfully treated.

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