scholarly journals BergaCare SmartLipids: commercial lipophilic active concentrates for improved performance of dermal products

2019 ◽  
Vol 10 ◽  
pp. 2152-2162 ◽  
Author(s):  
Florence Olechowski ◽  
Rainer H Müller ◽  
Sung Min Pyo
Keyword(s):  
Skin Irritation ◽  
Physical Stability ◽  
Skin Barrier ◽  
Lipid Nanoparticles ◽  
Lipid Modification ◽  
Submicron Particle ◽  
Penetration Enhancement ◽  
Skin Tolerability ◽  
Improved Performance ◽  
Underlying Mechanisms

SmartLipids are the latest generation of dermal lipid nanoparticles with solid particle matrix. Their characteristic properties resulting from the “chaotic” and disordered particle matrix structure are reviewed. These properties are high loading and firm inclusion of active agents, physical stability of the particle matrix lipid modification (primarily α, β′), and related to these three properties the improved chemical stabilization of labile active agents. Exemplarily data for these effects are shown and underlying mechanisms are discussed. Further, general properties of lipid nanoparticles, which are also exhibited by the SmartLipids, are reviewed. These include the restauration of the protective lipid skin barrier (anti-pollution effect), penetration enhancement by occlusion (invisible patch effect) and the option to control the release of active agents for optimized biological effect and reduction of side effects (e.g., skin irritation through sensitizing active agents), which improves the skin tolerability. Regulatory aspects, such as submicron particle status, excipients, and certifications, are also discussed.

Development of a topical adapalene-solid lipid nanoparticle loaded gel with enhanced efficacy and improved skin tolerability

RSC Advances ◽  
2015 ◽  
Vol 5 (55) ◽  
pp. 43917-43929 ◽  
Author(s):  
Harshad Harde ◽  
Ashish Kumar Agrawal ◽  
Mahesh Katariya ◽  
Dnyaneshwar Kale ◽  
Sanyog Jain
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Skin Irritation ◽  
Lipid Nanoparticles ◽  
Solid Lipid Nanoparticle ◽  
Solid Lipid ◽  
Lipid Nanoparticle ◽  
Skin Tolerability

The present investigation substantiates the efficacy of adapalene loaded solid lipid nanoparticles (Ada-SLNs) in ameliorating the skin irritation potential of adapalene owing to its altered skin distribution.

Rheological and morphological characterizations on physical stability of gamma-oryzanol-loaded solid lipid nanoparticles (SLNs)

Micron ◽  
2010 ◽  
Vol 41 (1) ◽  
pp. 51-58 ◽  
Author(s):  
Nispa Seetapan ◽  
Piyawan Bejrapha ◽  
Wanwisa Srinuanchai ◽  
Uracha Rungsardthong Ruktanonchai
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Physical Stability ◽  
Lipid Nanoparticles ◽  
Solid Lipid ◽  
Gamma Oryzanol

Ion Pair Strategy in Solid Lipid Nanoparticles: a Targeted Approach to Improve Epidermal Targeting with Controlled Adapalene Release, Resulting Reduced Skin Irritation

2020 ◽  
Vol 37 (8) ◽  
Author(s):  
Linna B. O. Rodrigues ◽  
Flávia A. Lima ◽  
Camila P. B. Alves ◽  
Elisângela Martins-Santos ◽  
Marta M. G. Aguiar ◽  
...  
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Skin Irritation ◽  
Lipid Nanoparticles ◽  
Ion Pair ◽  
Solid Lipid ◽  
Targeted Approach

Improved performance of a chitosan-based adsorbent for the sequestration of some transition metals

2001 ◽  
Vol 43 (11) ◽  
pp. 9-16 ◽  
Author(s):  
R. R. Navarro ◽  
K. Tatsumi
Keyword(s):  
Graft Polymerization ◽  
Physical Stability ◽  
Three Dimensional ◽  
Batch Adsorption ◽  
Capacity Enhancement ◽  
Modified Chitosan ◽  
Coordination Requirements ◽  
Acidic Conditions ◽  
Improved Performance ◽  
Chitosan Resin

Polyethyleneimine (PEI) was chemically introduced onto chitosan by its reaction with epoxide groups of grafted poly(glycidyl methacrylate) (poly(GMA)) chains for enhanced metal chelating properties and improved physical stability in acidic conditions. Graft polymerization of poly(GMA) onto chitosan was initiated by Ce(IV) ammonium nitrate (CAN). Infrared spectroscopy revealed the presence of significant epoxide groups to confirm the success of both grafting and amination stages. Batch adsorption experiments showed the higher affinity of the modified chitosan resin for Cu2+, Zn2+ and Pb2+. The capacity enhancement was even more pronounced in the case of Zn2+ and Pb2+, which exhibits more complicated three dimensional coordination requirements. Optimum metal adsorption occurs at above pH 4. Regeneration of the resin with sulphuric acid-ammonium sulphate was also found to be feasible.

scholarly journals Skin Barrier Abnormalities and Immune Dysfunction in Atopic Dermatitis

2020 ◽  
Vol 21 (8) ◽  
pp. 2867 ◽  
Author(s):  
Gabsik Yang ◽  
Jin Kyung Seok ◽  
Han Chang Kang ◽  
Yong-Yeon Cho ◽  
Hye Suk Lee ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Systemic Disease ◽  
Skin Barrier ◽  
Immune Dysregulation ◽  
Food Allergies ◽  
Atopic Diseases ◽  
Barrier Dysfunction ◽  
Underlying Mechanisms ◽  
Chronic Pruritus ◽  
And Function

Atopic dermatitis (AD) is a common and relapsing skin disease that is characterized by skin barrier dysfunction, inflammation, and chronic pruritus. While AD was previously thought to occur primarily in children, increasing evidence suggests that AD is more common in adults than previously assumed. Accumulating evidence from experimental, genetic, and clinical studies indicates that AD expression is a precondition for the later development of other atopic diseases, such as asthma, food allergies, and allergic rhinitis. Although the exact mechanisms of the disease pathogenesis remain unclear, it is evident that both cutaneous barrier dysfunction and immune dysregulation are critical etiologies of AD pathology. This review explores recent findings on AD and the possible underlying mechanisms involved in its pathogenesis, which is characterized by dysregulation of immunological and skin barrier integrity and function, supporting the idea that AD is a systemic disease. These findings provide further insights for therapeutic developments aiming to repair the skin barrier and decrease inflammation.

scholarly journals Enhanced Transdermal Delivery of Concentrated Capsaicin from Chili Extract-Loaded Lipid Nanoparticles with Reduced Skin Irritation

Pharmaceutics ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 463 ◽  
Author(s):  
Phunsuk Anantaworasakul ◽  
Wantida Chaiyana ◽  
Bozena B. Michniak-Kohn ◽  
Wandee Rungseevijitprapa ◽  
Chadarat Ampasavate
Keyword(s):  
Skin Irritation ◽  
Chorioallantoic Membrane ◽  
Crystallinity Index ◽  
Entrapment Efficiency ◽  
Lipid Nanoparticles ◽  
Loading Capacity ◽  
High Concentration ◽  
Fatty Esters ◽  
Solid Lipid

The aim of this study was to develop lipid-based nanoparticles that entrapped a high concentration of capsaicin (0.25%) from a capsicum oleoresin extract. The solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) were strategically fabricated to entrap capsaicin without a hazardous solvent. Optimized nanosize lipid particles with high capsaicin entrapment and loading capacity were achieved from pair-wise comparison of the solid lipid mixtures consisting of fatty esters and fatty alcohols, representing small and large crystal-structure molecules combined with a compatible liquid lipid and surfactants (crystallinity index = 3%). This report was focused on selectively captured capsaicin from oleoresin in amorphous chili extract-loaded NLCs with 85.27% ± 0.12% entrapment efficiency (EE) and 8.53% ± 0.01% loading capacity (LC). The particle size, polydispersity index, and zeta potential of chili extract-loaded NLCs were 148.50 ± 2.94 nm, 0.12 ± 0.03, and −29.58 ± 1.37 mV, respectively. The favorable zero-order kinetics that prolonged capsaicin release and the significantly faster transdermal penetration of the NLC attributed to the reduction in skin irritation of the concentrated capsaicin NLCs, as illustrated by the in vitro EpiDermTM three-dimensional human skin irritation test and hen’s egg test chorioallantoic membrane assay (HET-CAM).

scholarly journals Formation of ion pairing as an alternative to improve encapsulation and stability and to reduce skin irritation of retinoic acid loaded in solid lipid nanoparticles

2009 ◽  
Vol 381 (1) ◽  
pp. 77-83 ◽  
Author(s):  
Gisele A. Castro ◽  
Anna Luíza L.R. Coelho ◽  
Cleida A. Oliveira ◽  
Germán A.B. Mahecha ◽  
Rodrigo L. Oréfice ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Solid Lipid Nanoparticles ◽  
Skin Irritation ◽  
Ion Pairing ◽  
Lipid Nanoparticles ◽  
Solid Lipid

scholarly journals Effects of Cast Immobilisation on Skin Barrier Function

2020 ◽  
Vol 49 (6) ◽  
pp. 354-359
Author(s):  
Chin Yee Woo ◽  
Mark JA Koh ◽  
Winnie KY Fung ◽  
Cheri SH Chan ◽  
Chong Bing Chua ◽  
...  
Keyword(s):  
Stratum Corneum ◽  
Water Loss ◽  
Barrier Function ◽  
Skin Irritation ◽  
Skin Barrier ◽  
Transepidermal Water Loss ◽  
Skin Barrier Function ◽  
Hair Density ◽  
Cast Immobilisation ◽  
Volar Surface

Introduction: Cast immobilisation remains the mainstay of treatment for various fractures in paediatric patients, yet patients commonly complain of skin irritation and discomfort. This study aimed to perform a qualitative and quantitative evaluation of the effects of cast immobilisation on the skin of children and adolescents. Materials and Methods: Patients aged 6–17 years of age with a fracture treated in a fiberglass short-arm or short-leg cast were recruited. Transepidermal water loss (TEWL), stratum corneum (SC) hydration, hair density and presence of any skin signs were assessed before and after cast. Patients were required to complete a weekly questionnaire to rate itch, malodour, warmth, and dampness of the skin under the cast. Results: A total of 60 subjects completed the study. Thirty-six patients received a short-arm cast; 24 received a short-leg cast. Upon cast removal, TEWL was significantly increased on the volar surface of the arms and legs (P <0.05), and the dorsal surface of the arm (P <0.05). Likewise, SC hydration was significantly increased at most sites (P <0.05), except the volar surface of the leg (P = 0.513). There was no change in hair density. Throughout the duration of casting, there was an increase in itch and malodour scores. Conclusions: Moderate but significant changes in TEWL, SC hydration and subjective symptoms were observed during the duration of cast immobilisation, demonstrating that cast immobilisation for up to 4 weeks exerts moderate adverse impact on patients’ skin. Further studies to explore the use of better materials for cast immobilisation to improve skin barrier function and overall patient satisfaction are warranted. Ann Acad Med Singapore 2020;49:285–93 Ann Acad Med Singapore 2020;49:354–59 Key words: Cast immobilisation, Transepidermal water loss, Stratum corneum hydration

Sign in / Sign up

Export Citation Format

Share Document