scholarly journals Solution-phase automated synthesis of an α-amino aldehyde as a versatile intermediate

2017 ◽  
Vol 13 ◽  
pp. 106-110 ◽  
Author(s):  
Hisashi Masui ◽  
Sae Yosugi ◽  
Shinichiro Fuse ◽  
Takashi Takahashi
Keyword(s):  
Solution Phase ◽  
Automated Synthesis ◽  
Amino Aldehyde ◽  
Synthetic Intermediate

A solution-phase automated synthesis of the versatile synthetic intermediate, Garner’s aldehyde, was demonstrated. tert-Butoxycarbonyl (Boc) protection, acetal formation, and reduction of the ester to the corresponding aldehyde were performed utilizing our originally developed automated synthesizer, ChemKonzert. The developed procedure was also useful for the synthesis of Garner’s aldehyde analogues possessing fluorenylmethyloxycarbonyl (Fmoc) or benzyloxycarbonyl (Cbz) protection.

scholarly journals Application of an Automated Synthesis Suite to Parallel Solution-Phase Peptide Synthesis.

2001 ◽  
Vol 49 (9) ◽  
pp. 1147-1154 ◽  
Author(s):  
Noritaka KURODA ◽  
Taeko HATTORI ◽  
Yoko FUJIOKA ◽  
David G. CORK ◽  
Chieko KITADA ◽  
...  
Keyword(s):  
Peptide Synthesis ◽  
Solution Phase ◽  
Automated Synthesis ◽  
Parallel Solution

ChemInform Abstract: Application of a Unique Automated Synthesis System for Solution-Phase Peptide Synthesis.

ChemInform ◽  
2010 ◽  
Vol 27 (4) ◽  
pp. no-no
Author(s):  
T. SUGAWARA ◽  
K. KOBAYASHI ◽  
S. OKAMOTO ◽  
C. KITADA ◽  
M. FUJINO
Keyword(s):  
Peptide Synthesis ◽  
Solution Phase ◽  
Automated Synthesis ◽  
Synthesis System

scholarly journals Solution-Phase Automated Synthesis of Tripeptide Derivatives.

2001 ◽  
Vol 49 (9) ◽  
pp. 1138-1146 ◽  
Author(s):  
Noritaka KURODA ◽  
Taeko HATTORI ◽  
Chieko KITADA ◽  
Tohru SUGAWARA
Keyword(s):  
Solution Phase ◽  
Automated Synthesis

scholarly journals Application of a Unique Automated Synthesis System for Solution-phase Peptide Synthesis.

1995 ◽  
Vol 43 (8) ◽  
pp. 1272-1280 ◽  
Author(s):  
Tohru SUGAWARA ◽  
Kyoko KOBAYASHI ◽  
Shigeha OKAMOTO ◽  
Chieko KITADA ◽  
Masahiko FUJINO
Keyword(s):  
Peptide Synthesis ◽  
Solution Phase ◽  
Automated Synthesis ◽  
Synthesis System

Transition alpha structure in beta-isomorphous Nb-Hf alloys

1987 ◽  
Vol 45 ◽  
pp. 232-233
Author(s):  
R.W. Carpenter ◽  
Changhai Li ◽  
David J. Smith
Keyword(s):  
Solid Solution ◽  
Solution Phase ◽  
Miscibility Gap ◽  
Large Strains ◽  
Solid Solution Phase ◽  
Two Phase ◽  
Diffuse Intensity ◽  
Metastable Form ◽  
The Matrix ◽  
Equilibrium Morphology

Binary Nb-Hf alloys exhibit a wide bcc solid solution phase field at temperatures above the Hfα→ß transition (2023K) and a two phase bcc+hcp field at lower temperatures. The β solvus exhibits a small slope above about 1500K, suggesting the possible existence of a miscibility gap. An earlier investigation showed that two morphological forms of precipitate occur during the bcc→hcp transformation. The equilibrium morphology is rod-type with axes along <113> bcc. The crystallographic habit of the rod precipitate follows the Burgers relations: {110}||{0001}, <112> || <1010>. The earlier metastable form, transition α, occurs as thin discs with {100} habit. The {100} discs induce large strains in the matrix. Selected area diffraction examination of regions ∼2 microns in diameter containing many disc precipitates showed that, a diffuse intensity distribution whose symmetry resembled the distribution of equilibrium α Bragg spots was associated with the disc precipitate.

Predicted Solution Phase Forms of Heavy Metals in Sewage Sludge‐Treated Soils

1982 ◽  
Vol 11 (2) ◽  
pp. 182-186 ◽  
Author(s):  
W. E. Emmerich ◽  
L. J. Lund ◽  
A. L. Page ◽  
A. C. Chang
Keyword(s):  
Heavy Metals ◽  
Sewage Sludge ◽  
Solution Phase

Solution Phase DNA-Compatible Pictet-Spengler Reaction Aided by Machine Learning Building Block Filtering

2020 ◽  
Author(s):  
Ke Li ◽  
Xiaohong Liu ◽  
Sixiu Liu ◽  
Yulong An ◽  
Yanfang Shen ◽  
...  
Keyword(s):  
Machine Learning ◽  
Building Block ◽  
Solution Phase

An Overview of the One-pot Synthesis of Imidazolines

2020 ◽  
Vol 24 (20) ◽  
pp. 2341-2355
Author(s):  
Thaipparambil Aneeja ◽  
Sankaran Radhika ◽  
Mohan Neetha ◽  
Gopinathan Anilkumar
Keyword(s):  
Asymmetric Catalysis ◽  
Organic Compounds ◽  
Ring Opening ◽  
Ecological Impact ◽  
Chiral Auxiliary ◽  
One Pot ◽  
One Pot Synthesis ◽  
The One ◽  
Synthetic Intermediate ◽  
Heterocyclic Moiety

One-pot syntheses are a simple, efficient and easy methodology, which are widely used for the synthesis of organic compounds. Imidazoline is a valuable heterocyclic moiety used as a synthetic intermediate, chiral auxiliary, chiral catalyst and a ligand for asymmetric catalysis. Imidazole is a fundamental unit of biomolecules that can be easily prepared from imidazolines. The one-pot method is an impressive approach to synthesize organic compounds as it minimizes the reaction time, separation procedures, and ecological impact. Many significant one-pot methods such as N-bromosuccinimide mediated reaction, ring-opening of tetrahydrofuran, triflic anhydrate mediated reaction, etc. were reported for imidazoline synthesis. This review describes an overview of the one-pot synthesis of imidazolines and covers literature up to 2020.

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