scholarly journals Continuous-flow synthesis of highly functionalized imidazo-oxadiazoles facilitated by microfluidic extraction

2017 ◽  
Vol 13 ◽  
pp. 239-246 ◽  
Author(s):  
Ananda Herath ◽  
Nicholas D P Cosford
Keyword(s):  
High Purity ◽  
Continuous Flow ◽  
Flow System ◽  
Single Step ◽  
Polar Solvents ◽  
Flow Synthesis ◽  
Multistep Synthesis ◽  
High Boiling Point ◽  
Liquid Microextraction ◽  
Continuous Flow Method

A versatile continuous-flow synthesis of highly functionalized 1,2,4-oxadiazoles starting from carboxylic acids is reported. This process was applied to the multistep synthesis of imidazo[1,2-a]pyridin-2-yl-1,2,4-oxadiazoles, using a three reactor, multistep continuous-flow system without isolation of intermediates. This continuous-flow method was successfully combined with a single-step liquid–liquid microextraction unit to remove high boiling point polar solvents and impurities and provides the target compounds in high purity with excellent overall yields.

scholarly journals Continuous flow synthesis of diaryl ketones by coupling of aryl Grignard reagents with acyl chlorides under mild conditions in the ecofriendly solvent 2-methyltetrahydrofuran

RSC Advances ◽  
2019 ◽  
Vol 9 (4) ◽  
pp. 2199-2204 ◽  
Author(s):  
Chuan-Tao Zhang ◽  
Rui Zhu ◽  
Zheng Wang ◽  
Bing Ma ◽  
Adrian Zajac ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Parallel Synthesis ◽  
Grignard Reagents ◽  
Acyl Chlorides ◽  
Flow Synthesis ◽  
Flow Method ◽  
Mild Conditions ◽  
Continuous Flow Method

Continuous flow method for parallel synthesis of diaryl ketones using commercially available reagents.

scholarly journals p-Xylene from 2,5-dimethylfuran and acrylic acid using zeolite in a continuous flow system

2020 ◽  
Vol 22 (21) ◽  
pp. 7398-7405 ◽  
Author(s):  
Jose Alirio Mendoza Mesa ◽  
Francesco Brandi ◽  
Irina Shekova ◽  
Markus Antonietti ◽  
Majd Al-Naji
Keyword(s):  
Acrylic Acid ◽  
Lignocellulosic Biomass ◽  
Continuous Flow ◽  
Flow System ◽  
Diels Alder ◽  
Flow Synthesis ◽  
Continuous Flow System ◽  
System P ◽  
Different Types

The continuous flow synthesis of p-xylene (pXL) via Diels–Alder cycloaddition of lignocellulosic biomass-derivable 2,5-dimethylfuran (DMF) and acrylic acid (AA) was performed over different types of zeolites.

scholarly journals One-flow synthesis of tetrahydrocannabinol and cannabidiol using homo- and heterogeneous Lewis acids

2021 ◽  
Author(s):  
Victor R. L. J. Bloemendal ◽  
Bram Spierenburg ◽  
Thomas J. Boltje ◽  
Jan C. M. van Hest ◽  
Floris P. J. T. Rutjes
Keyword(s):  
Continuous Flow ◽  
Lewis Acids ◽  
Ring Opening ◽  
Flow System ◽  
Flow Chemistry ◽  
Batch Processes ◽  
Flow Synthesis ◽  
Biologically Relevant ◽  
Continuous Flow Chemistry ◽  
Biologically Relevant Molecules

AbstractContinuous flow chemistry holds great potential for the production of biologically relevant molecules. Herein, we present an approach for the continuous synthesis of cannabidiol and tetrahydrocannabinol in a one-flow system. The designed route consists of a reaction cascade involving Friedel-Crafts alkylation, subsequent ring opening and cyclisation in up to 45% yield. The reactions were successfully performed using both hetero- and homogeneous Lewis acids in continuous flow and provide yields that are similar to comparable batch processes. Graphical abstract

scholarly journals Continuous-flow synthesis of 3,5-disubstituted pyrazoles via sequential alkyne homocoupling and Cope-type hydroamination

RSC Advances ◽  
2019 ◽  
Vol 9 (15) ◽  
pp. 8197-8203 ◽  
Author(s):  
Sándor B. Ötvös ◽  
Ádám Georgiádes ◽  
Dániel Ozsvár ◽  
Ferenc Fülöp
Keyword(s):  
Continuous Flow ◽  
Flow Synthesis ◽  
Flow Method ◽  
Continuous Flow Method

A telescoped continuous-flow method is presented for the synthesis of 3,5-disubstituted pyrazoles via copper-mediated alkyne homocoupling and Cope-type hydroamination of the intermediary 1,3-dialkynes.

A two-step continuous flow synthesis of 1,4-disubstituted 1,2,3-triazoles under metal- and azide-free conditions

RSC Advances ◽  
2016 ◽  
Vol 6 (92) ◽  
pp. 89073-89079 ◽  
Author(s):  
Jiajia Gu ◽  
Zheng Fang ◽  
Zhao Yang ◽  
Xin Li ◽  
Ning Zhu ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Flow System ◽  
New Method ◽  
Flow Synthesis ◽  
Continuous Flow System

A new method for the formation of 1,4-disubstituted 1,2,3-triazoles in a continuous flow system under metal- and azide-free conditions has been developed. The corresponding products were obtained in moderate to good yields.

Continuous-flow enzymic method evaluated for measurement of serum triglycerides with use of an improved lipase reagent.

1978 ◽  
Vol 24 (11) ◽  
pp. 2018-2019 ◽  
Author(s):  
K Whitlow ◽  
N Gochman
Keyword(s):  
Continuous Flow ◽  
Flow System ◽  
Free Glycerol ◽  
Fluorometric Method ◽  
Serum Triglycerides ◽  
Microbial Lipase ◽  
Flow Method ◽  
Dual Channel ◽  
Continuous Flow Method ◽  
Total Triglyceride

Abstract We compared a modified enzymic continuous-flow method for serum triglycerides, in which a microbial lipase is used without protease, to an extraction-fluorometric method. Results (for total--blank) correlated well with those by the comparison procedure: enzymic = 1.002 fluorometric--14 mg/liter; r = 0.9968. Serum blanks were measured for each sample in both methods, and the concentration of free glycerol measured by the enzymic method was shown to be as much as 15 to 71% of the total triglyceride result in 7% of the samples analyzed. The dual-channel continuous-flow system provides automatic free-glycerol blank subtraction for the enzymic method.

scholarly journals Greener Synthesis of Pristane by Flow Dehydrative Hydrogenation of Allylic Alcohol Using a Packed-Bed Reactor Charged by Pd/C as a Single Catalyst

Molecules ◽  
2021 ◽  
Vol 26 (19) ◽  
pp. 5845
Author(s):  
Takayoshi Kasakado ◽  
Yuki Hirobe ◽  
Akihiro Furuta ◽  
Mamoru Hyodo ◽  
Takahide Fukuyama ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Molecular Hydrogen ◽  
Flow System ◽  
Acid Catalyst ◽  
Packed Bed ◽  
Allylic Alcohol ◽  
Packed Bed Reactor ◽  
Flow Synthesis ◽  
Greener Synthesis ◽  
Basking Shark

Our previous work established a continuous-flow synthesis of pristane, which is a saturated branched alkane obtained from a Basking Shark. The dehydration of an allylic alcohol that is the key to a tetraene was carried out using a packed-bed reactor charged by an acid–silica catalyst (HO-SAS) and flow hydrogenation using molecular hydrogen via a Pd/C catalyst followed. The present work relies on the additional propensity of Pd/C to serve as an acid catalyst, which allows us to perform a flow synthesis of pristane from the aforementioned key allylic alcohol in the presence of molecular hydrogen using Pd/C as a single catalyst, which is applied to both dehydration and hydrogenation. The present one-column-two-reaction-flow system could eliminate the use of an acid catalyst such as HO-SAS and lead to a significant simplification of the production process.

Nitrification and Autotrophic Denitrification in Calcium Alginate Beads

1987 ◽  
Vol 19 (1-2) ◽  
pp. 175-182 ◽  
Author(s):  
Z. Lewandowski ◽  
R. Bakke ◽  
W. G. Characklis
Keyword(s):  
Calcium Carbonate ◽  
Calcium Ions ◽  
Continuous Flow ◽  
Calcium Alginate ◽  
Microbial Respiration ◽  
Flow System ◽  
Alginate Beads ◽  
Alginate Gel ◽  
Gel Beads ◽  
Calcium Alginate Gel

Immobilization of nitrifiers and autotrophic denitrifiers (Thiobacillus denitrificans) within calcium alginate gel was demonstrated. Calcium carbonate reagent was immobilized along with bacteria as the stabilizing agent. Protons released as a result of microbial respiration reacted with calcium carbonate producing calcium ions which internally stabilized the calcium alginate gel. The microbially active gel beads were mechanically stable and active for three months in a continuous flow system without addition of calcium.

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