scholarly journals Photocatalytic trifluoromethoxylation of arenes and heteroarenes in continuous-flow

2020 ◽  
Vol 16 ◽  
pp. 1305-1312
Author(s):  
Alexander V Nyuchev ◽  
Ting Wan ◽  
Borja Cendón ◽  
Carlo Sambiagio ◽  
Job J C Struijs ◽  
...  
Keyword(s):  
Residence Time ◽  
Continuous Flow ◽  
Reaction Yield ◽  
Flow Conditions ◽  
Flow Microreactor ◽  
Microreactor Technology

The first example of photocatalytic trifluoromethoxylation of arenes and heteroarenes under continuous-flow conditions is described. Application of continuous-flow microreactor technology allowed to reduce the residence time up to 16 times in comparison to the batch procedure, while achieving similar or higher yields. In addition, the use of inorganic bases was demonstrated to increase the reaction yield under batch conditions.

Protein and antibody functionalization using continuous flow microreactor technology

2015 ◽  
Vol 5 (3) ◽  
pp. 151-154 ◽  
Author(s):  
Meaghan M. Sebeika ◽  
Nicholas G. Gedeon ◽  
Sara Sadler ◽  
Nicholas L. Kern ◽  
Devan J. Wilkins ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Flow Microreactor ◽  
Microreactor Technology

Evaluation of a Reverse Oscillatory Flow Microreactor Design for the Synthesis of Uniformly-Sized Nanoparticles

2011 ◽  
Author(s):  
Daniel A. Peterson ◽  
Anna E. Garrison ◽  
Brian K. Paul
Keyword(s):  
Residence Time ◽  
Oscillatory Flow ◽  
Mixing Time ◽  
Mixing Times ◽  
Size Distributions ◽  
Flow Conditions ◽  
Particle Size Distributions ◽  
Advective Flow ◽  
Flow Microreactor ◽  
Residence Time Distributions

Computational fluid dynamics is used to refine the operating parameters of a Reverse Oscillatory Flow (ROF) microreaction system for the synthesis of uniformly-sized nanoparticles. The ROF mixing system uses highly advective flow regions to achieve high quality mixing over short mixing lengths. The mixing system is further enhanced by sinusoidal inlet flow conditions which create plugs having reduced diffusional lengths. Flow conditions leading to plug creation were found to be chiefly responsible for shorter mixing times. Residence time distributions (of simulated inert particles) were found to decrease with increasing pump displacement. It is expected that these conditions will lead to smaller particle size distributions. Mixing quality and residence time distribution are not captured well by Reynolds or Strouhal numbers; however the maximum inlet Reynolds number does correlate well with mixing time trends. Implications for flow conditions are discussed.

scholarly journals Flow Giese reaction using cyanoborohydride as a radical mediator

2013 ◽  
Vol 9 ◽  
pp. 1791-1796 ◽  
Author(s):  
Takahide Fukuyama ◽  
Takuji Kawamoto ◽  
Mikako Kobayashi ◽  
Ilhyong Ryu
Keyword(s):  
Residence Time ◽  
Continuous Flow ◽  
Flow System ◽  
Ethyl Acrylate ◽  
Sodium Cyanoborohydride ◽  
Reaction Conditions ◽  
Radical Trap ◽  
Flow Microreactor ◽  
Alkyl Iodides ◽  
Tertiary Alkyl

Tin-free Giese reactions, employing primary, secondary, and tertiary alkyl iodides as radical precursors, ethyl acrylate as a radical trap, and sodium cyanoborohydride as a radical mediator, were examined in a continuous flow system. With the use of an automated flow microreactor, flow reaction conditions for the Giese reaction were quickly optimized, and it was found that a reaction temperature of 70 °C in combination with a residence time of 10–15 minutes gave good yields of the desired addition products.

scholarly journals Flow Electrochemical Cyclizations via Amidyl Radicals: Easy Access to Cyclic Ureas

SynOpen ◽  
2019 ◽  
Vol 03 (01) ◽  
pp. 46-48 ◽  
Author(s):  
Nisar Ahmed ◽  
Aggeliki Vgenopoulou
Keyword(s):  
Working Conditions ◽  
Continuous Flow ◽  
Flow Chemistry ◽  
Batch Processes ◽  
High Yield ◽  
Easy Access ◽  
Chemical Transformations ◽  
Flow Microreactor ◽  
Microreactor Technology ◽  
Safe Working

Flow chemistry has advantages over batch processes and can achieve the synthesis of substances in high yield under safe working conditions. The combination of electrochemistry and flow microreactor technology has made chemical transformations possible without the use of oxidants or catalysts. Herein, we report flow electrosynthesis of cyclic ureas via oxyamination of N-allylic ureas. We have found that continuous flow is able to outperform its batch counterpart, producing cyclic ureas in excellent yields.

Asymmetric copper-catalyzed fluorination of cyclic β-keto esters in a continuous-flow microreactor

2020 ◽  
Vol 18 (26) ◽  
pp. 4927-4931
Author(s):  
Yi-Feng Wang ◽  
Zhen-Hui Jiang ◽  
Ming-Ming Chu ◽  
Suo-Suo Qi ◽  
Hao Yin ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Flow Conditions ◽  
Keto Esters ◽  
Flow Microreactor

A highly enantioselective fluorination using diphenylamine linked bis(oxazoline)–Cu(OTf)2 complexes as a catalyst under continuous-flow conditions has been established.

A monolithic 5-(pyrrolidin-2-yl)tetrazole flow microreactor for the asymmetric aldol reaction in water–ethanol solvent

2016 ◽  
Vol 1 (2) ◽  
pp. 183-193 ◽  
Author(s):  
Roberto Greco ◽  
Lorenzo Caciolli ◽  
Anna Zaghi ◽  
Omar Pandoli ◽  
Olga Bortolini ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Monolithic Column ◽  
Aldol Reaction ◽  
Flow Conditions ◽  
Asymmetric Aldol ◽  
Long Term Stability ◽  
Flow Microreactor ◽  
Asymmetric Aldol Reaction ◽  
Reaction In Water

An organocatalytic polystyrene monolithic column produces chiral β-hydroxyketones under benign, continuous-flow conditions with high long-term stability.

scholarly journals Halogenation of organic compounds using continuous flow and microreactor technology

2017 ◽  
Vol 2 (1) ◽  
pp. 7-19 ◽  
Author(s):  
David Cantillo ◽  
C. Oliver Kappe
Keyword(s):  
Organic Compounds ◽  
Continuous Flow ◽  
Flow Conditions ◽  
Microreactor Technology

Halogenation reactions involving highly reactive halogenating agents can be performed safely and with improved efficiency and selectivity under continuous flow conditions.

Metal–organic frameworks for the removal of the emerging contaminant atenolol under real conditions

2021 ◽  
Vol 50 (7) ◽  
pp. 2493-2500
Author(s):  
Sara Rojas ◽  
Jorge A. R. Navarro ◽  
Patricia Horcajada
Keyword(s):  
Continuous Flow ◽  
Metal Organic Frameworks ◽  
Fixed Bed ◽  
Emerging Contaminant ◽  
Flow Conditions ◽  
Metal Organic ◽  
Fixed Bed System

A defective Metal-Organic Frameworks as an improved material for the construction of a fixed-bed system working under continuous flow conditions for the removal of the emerging contaminant atenolol.

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