scholarly journals Electrocatalytic C(sp3)–H/C(sp)–H cross-coupling in continuous flow through TEMPO/copper relay catalysis

2021 ◽  
Vol 17 ◽  
pp. 2650-2656
Author(s):  
Bin Guo ◽  
Hai-Chao Xu
Keyword(s):  
Continuous Flow ◽  
Supporting Electrolyte ◽  
Cross Coupling ◽  
Terminal Alkynes ◽  
Low Concentration ◽  
Flow Microreactor ◽  
Chemical Oxidants ◽  
Flow Through

Electrocatalytic dehydrogenative C(sp3)–H/C(sp)–H cross-coupling of tetrahydroisoquinolines with terminal alkynes has been achieved in a continuous-flow microreactor through 2,2,6,6-tetramethylpiperidine 1-oxyl (TEMPO)/copper relay catalysis. The reaction is easily scalable and requires low concentration of supporting electrolyte and no external chemical oxidants or ligands, providing straightforward and sustainable access to 2-functionalized tetrahydroisoquinolines.

Room Temperature Flow Electrochemistry as a Means of Retaining the “Memory of Chirality” via Hofer Moest Type Reaction

2020 ◽  
Author(s):  
Tomas Hardwick ◽  
Rossana Cicala ◽  
Nisar Ahmed
Keyword(s):  
Continuous Flow ◽  
Room Temperature ◽  
Biological Activities ◽  
Supporting Electrolyte ◽  
Enantiomeric Excess ◽  
Flow Chemistry ◽  
Batch Processes ◽  
Enabling Technology ◽  
Chiral Compounds ◽  
Memory Of Chirality

<p>Many chiral compounds have become of great interest to the pharmaceutical industry as they possess various biological activities. Concurrently, the concept of “memory of chirality” has been proven as a powerful tool in asymmetric synthesis, while flow chemistry has begun its rise as a new enabling technology to add to the ever increasing arsenal of techniques available to the modern day chemist. Here, we have employed a new simple electrochemical microreactor design to oxidise an L-proline derivative at room temperature in continuous flow. Flow performed in microreactors offers up a number of benefits allowing reactions to be performed in a more convenient and safer manner, and even allow electrochemical reactions to take place without a supporting electrolyte due to a very short interelectrode distance. By the comparison of electrochemical oxidations in batch and flow we have found that continuous flow is able to outperform its batch counterpart, producing a good yield (71%) and a better enantiomeric excess (64%) than batch with a 98% conversion. We have, therefore, provided evidence that continuous flow chemistry has the potential to act as a new enabling technology to replace some aspects of conventional batch processes. </p>

Biosolids Reuse: Continuous Flow-Through Column Testing of Biosolids-Derived Biochar to Sorb Micropollutants

2017 ◽  
Vol 2017 (1) ◽  
pp. 302-305
Author(s):  
L.K Kimbell ◽  
Y Tong ◽  
A Avila ◽  
B. K Mayer ◽  
P. J McNamara
Keyword(s):  
Continuous Flow ◽  
Column Testing ◽  
Flow Through

Functional response of Fucus vesiculosus communities to tributyltin measured in an in situ continuous flow-through system

Hydrobiologia ◽  
1989 ◽  
Vol 188-189 (1) ◽  
pp. 277-283 ◽  
Author(s):  
C. Lindblad ◽  
U. Kautsky ◽  
C. André ◽  
N. Kautsky ◽  
M. Tedengren
Keyword(s):  
Functional Response ◽  
Continuous Flow ◽  
Fucus Vesiculosus ◽  
Flow Through

scholarly journals Atom-Economical Cross-Coupling of Internal and Terminal Alkynes to Access 1,3-Enynes

2021 ◽  
Author(s):  
Mingyu Liu ◽  
Tianhua Tang ◽  
Omar Apolinar ◽  
Rei Matsuura ◽  
Carl A. Busacca ◽  
...  
Keyword(s):  
Cross Coupling ◽  
Terminal Alkynes

scholarly journals ZrCl2(η-C5Me5)2-AlHCl2·(THF)2: efficient hydroalumination of terminal alkynes and cross-coupling of the derived alanes

2013 ◽  
Vol 49 (15) ◽  
pp. 1488 ◽  
Author(s):  
Philip Andrews ◽  
Christopher M. Latham ◽  
Marc Magre ◽  
Darren Willcox ◽  
Simon Woodward
Keyword(s):  
Cross Coupling ◽  
Terminal Alkynes

scholarly journals Iron/copper-catalyzed C–C cross-coupling of aryl iodides with terminal alkynes

2008 ◽  
Vol 49 (41) ◽  
pp. 5961-5964 ◽  
Author(s):  
Chandra M. Rao Volla ◽  
Pierre Vogel
Keyword(s):  
Cross Coupling ◽  
Terminal Alkynes ◽  
Iron Copper ◽  
Aryl Iodides
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