Clinical–pathologic Agreement for Oral Lesions in an Oral Medicine Setting

2016 ◽  
Vol 2 (1) ◽  
pp. 1-10 ◽  
Author(s):  
Alessandro Villa ◽  
Francesco Nordio ◽  
Laura Strohmenger ◽  
Silvio Abati
Keyword(s):  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Weighted Kappa ◽  
Mucous Membrane Pemphigoid ◽  
Histopathological Diagnosis ◽  
Severe Dysplasia ◽  
Oral Lesions ◽  
Oral Medicine ◽  
Squamous Papilloma ◽  
Oral Lichen

Background: Histopathological examination remains the gold standard for the diagnosis of oral mucosal lesions. To date little is known on the clinical–pathologic agreement for oral lesions diagnosed by oral medicine experts.  Objective: This retrospective study attempts to quantify the clinical–pathologic agreement for oral lesions diagnosed by oral medicine experts. Methods: Data were collected retrospectively from the medical records of all new oral medicine consultations. The clinical diagnosis provided by an oral medicine expert was compared to the histopathological diagnosis. Clinical–pathologic agreement was estimated as the percentage agreement and was measured using weighted Kappa. Results: The most common oral lesions were oral lichen planus (34.7%), traumatic fibroma (23.4%), squamous cell carcinoma (SCC) or severe dysplasia (6.7%), mucous membrane pemphigoid (MMP) (5.7%), leukoplakia (5.6%) and squamous papilloma (4.3%). The overall clinical–pathologic agreement for all lesions had a weighted kappa of 0.81 [95%CI 0.78% to 0.85%]. The concordance for the most common oral lesions in the study population was 90.2%, with a weighted kappa of 0.88 [95%CI 0.85% to 0.92%]. The clinical–pathologic agreement for SCC/severe dysplasia was 78.7%, for traumatic fibroma 91.4%, for leukoplakia 97.4%, for oral lichen planus 93.8%, for squamous papilloma 96.7% and for MMP 65%. Conclusions: The overall concordance between clinical and histopathological diagnosis for oral lesions was excellent. Dentists have the unique opportunity to refer patients to oral medicine experts for diagnosis and management of oral diseases. Given their expertise patients may require fewer visits for diagnostic purposes.

scholarly journals Medications in Thai Patients with Oral Lichen Planus, Oral Lichenoid Drug Reaction and Glossitis

2014 ◽  
Vol 3 (2) ◽  
pp. 73-76 ◽  
Author(s):  
Napat Nalamliang ◽  
Nichruethai Tangnantachai ◽  
Kobkan Thongprasom
Keyword(s):  
Drug Reaction ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Antihypertensive Drugs ◽  
Oral Lesions ◽  
Oral Medicine ◽  
Dental Patients ◽  
The Relationship ◽  
Oral Lichen ◽  
Hypolipidemic Drugs

ABSTRACT Introduction Medications have been widely used in the dental patients for the treatment of their systemic diseases. In fact, those drugs have some side-effects to many organs and also the oral cavity. The aim of our study was to investigate the relationship between medications and oral lichen planus (OLP), oral lichenoid drug reaction (OLDR) and glossitis (GT) in Thai patients. Materials and methods One hundred and thirty-eight cases of Thai patients were included in this study. Medical records of all cases with oral lesions and symptoms referred to the oral medicine clinic during 2007 to 2010 were extracted. Oral lichen planus group consisted of 88 cases, GT 26 cases and OLDR 24 cases. All data were analyzed using SPSS for Windows version 11.5. Results In our study, 75.5% of patients used more than one medication while single drug used was 24.5%. Antihypertensive drugs were the most commonly used in all groups. Antihypertensive and hypolipidemic drugs were equally taken 22.4% in OLP patients. Patients with OLDR taking antihypertensive in 54.2% followed by hypolipidemic (37.5%), NSAIDs (25%), hypoglycemic/antiplatelet (16.7%) each and others 25%. Patients in GT group were also used antihypertensive drugs 35%, NSAIDs 25%, hypolipidemic 20% respectively. Conclusion Most of patients with oral lesions took more than one medication. Antihypertensive drugs were the most commonly used in Thai patients with oral lesions. How to cite this article Nalamliang N, Tangnantachai N, Thongprasom K. Medications in Thai Patients with Oral Lichen Planus, Oral Lichenoid Drug Reaction and Glossitis. Int J Experiment Dent Sci 2014;3(2):73-76.

Photodynamic therapy in the treatment of oral lichen planus with moderate‐to‐severe dysplasia: A case report

2020 ◽  
Vol 33 (6) ◽  
Author(s):  
Qianhui Shang ◽  
Zhen Wang ◽  
Yunmei Dong ◽  
Luyao Cai ◽  
Fei Mao ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Case Report ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Severe Dysplasia ◽  
Oral Lichen

scholarly journals Prevalence of desquamative gingivitis in dermatological lesions - A retrospective institution based study

2020 ◽  
Vol 11 (SPL3) ◽  
pp. 1259-1263
Author(s):  
Santosh Bala ◽  
Herald J. Sherlin ◽  
Vivek Narayan
Keyword(s):  
Oral Cavity ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Histopathological Diagnosis ◽  
Oral Manifestations ◽  
Dental Hospital ◽  
Study Population ◽  
The Common ◽  
Oral Lichen ◽  
Oral Involvement

The oral cavity is considered to be the window to your body because oral manifestations accompany many systemic diseases. In many instances, oral involvement precedes the appearance of other symptoms or lesions at other locations. The aim of this study is to find the correlation of these formative gingiva along with dermatological lesions. Details of patients reported with dermatological lesions to the dental hospital with oral manifestations were obtained from a detailed patient record. The data collected is tabulated graphically via SPSS for statistical analysis. 24 patients were reported with various dermatological lesions. 70% of female predilection was observed, and maximum patients carried the lesion for about 12 months. Out of the 24 patients, 70% show the presence of desquamative gingiva clinically. Histopathological diagnosis shows that 75% of the dermatological lesions present in the oral cavity is lichen planus. According to the current study population, dermatological lesions are the common cause of desquamative gingiva. The prevalence of oral lichen planus was higher and commonly seen along with desquamative gingiva.

scholarly journals Desquamative Gingivitis: Protocols, Procedures and Critical Issues

Proceedings ◽  
2019 ◽  
Vol 35 (1) ◽  
pp. 2
Author(s):  
Paola Carcieri
Keyword(s):  
Lichen Planus ◽  
Mucous Membrane ◽  
Plasma Cell ◽  
Oral Lichen Planus ◽  
Pemphigus Vulgaris ◽  
Mucous Membrane Pemphigoid ◽  
Critical Issues ◽  
Oral Lichen

Desquamative gingivitis (DG) isn’t a specific disorder; it simply represents the gingival manifestation associated with some heterogeneous mucocutaneous disorders, such as oral lichen planus (OLP), mucous membrane pemphigoid (MMP), pemphigus vulgaris (PV), plasma cell gingivitis (PCG) and few others. [...]

scholarly journals The Gingival Oral Lichen Planus: A Periodontal-Oral Medicine Approach

2019 ◽  
Vol 2019 ◽  
pp. 1-3
Author(s):  
Abdulhameed Alsarraf ◽  
Kunj Mehta ◽  
Nabil Khzam
Keyword(s):  
Lichen Planus ◽  
Oral Hygiene ◽  
Buccal Mucosa ◽  
Oral Lichen Planus ◽  
Multidisciplinary Approach ◽  
Accurate Diagnosis ◽  
Management Approach ◽  
Oral Medicine ◽  
Hygiene Measures ◽  
Oral Lichen

We present a case of a 77-year-old female who suffered from oral lichen planus (OLP) involving her gingiva and bilateral buccal mucosa for over 6 months. We showed that oral hygiene measures and conventional periodontal treatment and strict maintenance were sufficient to control the gingival involvement of OLP. The mechanism of OLP is complex and not yet fully understood. The focus of discussion in our case was that knowledge and understanding of gingival pathology are fundamental for a determined management approach. Our case was managed according to the suggested protocols in previous case studies. A multidisciplinary approach allowed for accurate diagnosis and treatment tailored to the presented case.

scholarly journals Oral Lichen Planus and Polycythemia: Possible Association

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Yassine Oueslati ◽  
Raouaa Belkacem Chebil ◽  
Haifa Regaieg ◽  
Lamia Oualha ◽  
Nabiha Douki
Keyword(s):  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Scientific Literature ◽  
Early Stage ◽  
Cell Mass ◽  
Chronic Inflammatory Disease ◽  
Oral Lesions ◽  
Immune Mediated ◽  
Immune Dysfunctions ◽  
Oral Lichen

Oral lichen planus is a chronic inflammatory disease of established immune-mediated pathogenesis that affects the oral mucosa. Polycythemia is a nonaggressive myeloproliferative disorder, characterized by an increase in red blood cell mass, often with uncontrolled production of granulocytes and platelets. Their association was rarely mentioned in the scientific literature. The aim of this paper was to report their occurrence in a 52-year-old male patient. Although a casual connection cannot be excluded, both diseases share many similarities in the immune dysfunctions involved in their pathogenesis and their clinical features. Such a hypothesis remains to be demonstrated by further studies. The presence of oral lesions should alert the clinicians in the process of identifying and early diagnosing these diseases. Thus, complications can be prevented and treatment can be started at an early stage, avoiding further damage.

scholarly journals Evidence of earlier thyroid dysfunction in newly diagnosed oral lichen planus patients: a hint for endocrinologists

2017 ◽  
Vol 6 (8) ◽  
pp. 726-730 ◽  
Author(s):  
Paolo G Arduino ◽  
Dora Karimi ◽  
Federico Tirone ◽  
Veronica Sciannameo ◽  
Fulvio Ricceri ◽  
...  
Keyword(s):  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Smoking Status ◽  
Oral Lesions ◽  
Thyroid Disorder ◽  
Newly Diagnosed ◽  
Hepatitis C Infection ◽  
Control Approach ◽  
Potentially Malignant ◽  
Oral Lichen

The association between oral lichen planus (OLP) and hypothyroidism has been debated with conflicting results: some authors detected a statistically significant association between these two, while others did not confirm it. The aim of this study was to evaluate the thyroid status in patients with newly diagnosed OLP to test the null hypothesis that thyroid disease is not associated with an increased incidence of oral lesions, with a prospective case-control approach. A total of 549 patients have been evaluated, of whom 355 were female. Odds ratio (OR) and 95% confidence intervals (CIs) were obtained. Patients suffering from thyroid diseases were associated with an almost 3-fold increased odds of having OLP (OR 2.85, 95% CI: 1.65–4.94), after adjusting this analysis for age, gender, body mass index, smoking status, diabetes, hypertension and hepatitis C infection. It would be appropriate to further investigate the possible concomitance of OLP among patients with thyroid disorder; endocrinologists should be aware of this association, especially because OLP is considered a potentially malignant oral disorder.

scholarly journals Malignant transformation of oral lichen planus: a retrospective study of 565 Japanese patients

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Fumihiko Tsushima ◽  
Jinkyo Sakurai ◽  
Atsushi Uesugi ◽  
Yu Oikawa ◽  
Toshimitsu Ohsako ◽  
...  
Keyword(s):  
Malignant Transformation ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Japanese Patients ◽  
Histopathological Diagnosis ◽  
Transformation Rate ◽  
Oral Epithelial Dysplasia ◽  
Oral Lichenoid Lesions ◽  
Potentially Malignant ◽  
Oral Lichen

Abstract Background Oral lichen planus (OLP) is a chronic inflammatory oral mucosa disease that is recognized as an oral potentially malignant disorder. However, the potentially malignant nature of OLP remains unclear. Methods We designed this study to examine the demographic and clinical characteristics of patients with OLP and evaluate the associated malignant transformation rate. A total of 565 patients with a clinical and histopathological diagnosis of OLP who presented at our department between 2001 and 2017 were retrospectively studied. Patients who had clinical and histopathological features of oral lichenoid lesions (OLLs) classified as oral lichenoid contact lesions, oral lichenoid drug reactions and oral lichenoid lesions of graft-versus-host disease were excluded. Results The study population included 123 men and 442 women aged 21–93 years (mean ± standard deviation, 60.5 ± 11.8). The 565 patients were followed up for a duration of 55.9 ± 45.3 months, during which 4 (0.7%) patients developed squamous cell carcinoma (SCC). In three of these 4 patients who developed SCC, the clinical type of OLP was the red type. Conclusions Our results suggested that OLP was associated with a low risk of malignant transformation. We recommend regular follow-up for OLP patients and clear differentiation of oral epithelial dysplasia and OLLs to enable early detection of malignant transformation. Further investigation of the clinical risk factors associated with malignant transformation is necessary.

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