scholarly journals Malignant transformation of oral lichen planus: a retrospective study of 565 Japanese patients

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Fumihiko Tsushima ◽  
Jinkyo Sakurai ◽  
Atsushi Uesugi ◽  
Yu Oikawa ◽  
Toshimitsu Ohsako ◽  
...  
Keyword(s):  
Malignant Transformation ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Japanese Patients ◽  
Histopathological Diagnosis ◽  
Transformation Rate ◽  
Oral Epithelial Dysplasia ◽  
Oral Lichenoid Lesions ◽  
Potentially Malignant ◽  
Oral Lichen

Abstract Background Oral lichen planus (OLP) is a chronic inflammatory oral mucosa disease that is recognized as an oral potentially malignant disorder. However, the potentially malignant nature of OLP remains unclear. Methods We designed this study to examine the demographic and clinical characteristics of patients with OLP and evaluate the associated malignant transformation rate. A total of 565 patients with a clinical and histopathological diagnosis of OLP who presented at our department between 2001 and 2017 were retrospectively studied. Patients who had clinical and histopathological features of oral lichenoid lesions (OLLs) classified as oral lichenoid contact lesions, oral lichenoid drug reactions and oral lichenoid lesions of graft-versus-host disease were excluded. Results The study population included 123 men and 442 women aged 21–93 years (mean ± standard deviation, 60.5 ± 11.8). The 565 patients were followed up for a duration of 55.9 ± 45.3 months, during which 4 (0.7%) patients developed squamous cell carcinoma (SCC). In three of these 4 patients who developed SCC, the clinical type of OLP was the red type. Conclusions Our results suggested that OLP was associated with a low risk of malignant transformation. We recommend regular follow-up for OLP patients and clear differentiation of oral epithelial dysplasia and OLLs to enable early detection of malignant transformation. Further investigation of the clinical risk factors associated with malignant transformation is necessary.

scholarly journals Malignant Transformation of Oral Lichen Planus: A Retrospective Study of 565 Japanese Patients

2021 ◽  
Author(s):  
Fumihiko Tsushima ◽  
Jinkyo Sakurai ◽  
Atsushi Uesugi ◽  
Yu Oikawa ◽  
Toshimitsu Ohsako ◽  
...  
Keyword(s):  
Malignant Transformation ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Japanese Patients ◽  
Histopathological Diagnosis ◽  
Oral Epithelial Dysplasia ◽  
Oral Lichenoid Lesions ◽  
Potentially Malignant ◽  
Clear Differentiation ◽  
Oral Lichen

Abstract Objective Oral lichen planus (OLP) is a chronic inflammatory oral mucosa disease that is recognized as an oral potentially malignant disorder. However, the potentially malignant nature of OLP remains unclear.Materials and Methods We designed this study to examine the demographic and clinical characteristics of OLP and evaluate its malignant potential. A total of 565 patients with a clinical and histopathological diagnosis of OLP who presented at our department between 2001 and 2017 were retrospectively studied. Patients who had clinical and histopathological features of oral lichenoid lesions (OLLs) classified as oral lichenoid contact lesions (OLCLs), oral lichenoid drug reactions (OLDRs) and oral lichenoid lesions of graft-versus-host disease (OLL-GVHD) were excluded.Results The study population included 123 men and 442 women aged 21-93 years (median, 62 years). The 565 patients were followed up for an average duration of 55.9 months, during which 4 (0.7%) patients developed squamous cell carcinoma (SCC). In three of these 4 patients who developed SCC, the clinical type of OLP was the red type.Conclusions Our results suggested that OLP was associated with a low risk of malignant transformation. Further investigation of the clinical risk factors associated with malignant transformation is necessary.Clinical relevance We recommend regular follow-up for OLP patients and clear differentiation of oral epithelial dysplasia (OED) and OLLs to enable early detection of malignant transformation.

Assessment and Comparison of Salivary Survivin Biomarker in Oral Leukoplakia, Oral Lichen Planus, and Oral Cancer: A Comparative Study

2017 ◽  
Vol 8 (2) ◽  
pp. 73-76 ◽  
Author(s):  
Ruchika Garg ◽  
Arvind V Shetti ◽  
Anjana S Bagewadi
Keyword(s):  
Oral Cancer ◽  
Comparative Study ◽  
Malignant Transformation ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Oral Leukoplakia ◽  
Control Group ◽  
Significant Difference ◽  
Potentially Malignant ◽  
Oral Lichen

ABSTRACT Introduction Oral squamous cell carcinoma (OSCC) is the most common malignant tumor of the oral cavity. It is preceded by various potentially malignant conditions like oral leukoplakia and oral lichen planus. Survivin is an inhibitor of apoptosis whose levels have been found increased in oral cancer as well as various potentially malignant conditions. Thus survivin can act as a biomarker and help in early detection of potentially malignant conditions which can prevent its transformation into malignancy. Aim To assess and compare the level of total human salivary survivin in oral leukoplakia, oral lichen planus, oral cancer, and control group. Materials and methods A total of 96 subjects were included in the study, which were further grouped into 24 in each group. The saliva was analyzed for survivin level among all the four groups. Survivin concentration (pg/mL) was studied in relation to clinical data. The results were analyzed using Mann—Whitney U test to derive the statistical difference. Results The average of levels of survivin in control group was 0.199 pg/mL, in oral leukoplakia group 0.312 pg/mL, in oral lichen planus group 0.380 pg/mL, and in oral cancer group 0.430 pg/mL. A comparison of all these groups revealed statistically significant difference among the groups. Conclusion Survivin may not be considered as an independent predictor of the malignant transformation for premalignant lesions but it can be an indicator for an increased risk of malignant transformation. How to cite this article Garg R, Shetti AV, Bagewadi AS. Assessment and Comparison of Salivary Survivin Biomarker in Oral Leukoplakia, Oral Lichen Planus, and Oral Cancer: A Comparative Study. World J Dent 2017;8(2):73-76.

scholarly journals The Characteristics of Patients with Oral Lichen Planus and Malignant Transformation—A Retrospective Study of 271 Patients

2021 ◽  
Vol 18 (12) ◽  
pp. 6525
Author(s):  
Vladimíra Radochová ◽  
Romana Koberová Ivančaková ◽  
Ondřej Heneberk ◽  
Radovan Slezák
Keyword(s):  
Retrospective Study ◽  
Malignant Transformation ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Chronic Inflammatory Disease ◽  
University Hospital ◽  
Unknown Etiology ◽  
Transformation Rate ◽  
Oral Lichen

Introduction: Oral lichen planus (OLP) is a chronic inflammatory disease with an unknown etiology rating among oral potentially malignant disorder. The aim of the study was to determine the epidemiological and clinical characteristics of the patients with OLP and rate of malignant transformation. Patients and methods: Data were obtained from the medical records of 271 patients referred to the Oral Medicine Unit at the University Hospital in Hradec Králové diagnosed with oral lichen planus in the period of 2003–2020. The records were retrospectively analyzed. The following clinical data were retrieved from the medical charts: gender, age, systemic diseases, alcohol and tobacco consumption, localization/clinical appearance of lesions, distribution of the lesions, presence of the symptoms, treatment provided and malignant transformation. Results: A total of 271 charts of patients with confirmed diagnosis of OLP were retrospectively analyzed, of whom, 66.4% (180/271) were women and 33.6% (91/271) were men. The mean age of the patients was 56.0 (18.2–85.0) years. The median follow-up of all patients was 15.2 months. Overall, 2 patients (2/271, 0.74%) meeting the above-mentioned criteria for malignant transformation were identified during the follow-up period. Both patients suffered from erosive type OLP and developed squamous cell carcinoma of the tongue. Conclusions: This retrospective study is in concordance with other studies showing the similar profile and clinical features of the patients with OLP. Malignant transformation rate was 0.74%.

scholarly journals Clinicopathologic Correlation of Oral Lichen Planus and Oral Lichenoid Lesions: A Preliminary Study

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Marinka Mravak-Stipetić ◽  
Božana Lončar-Brzak ◽  
Iva Bakale-Hodak ◽  
Ivan Sabol ◽  
Sven Seiwerth ◽  
...  
Keyword(s):  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Plasma Cells ◽  
Clinical Feature ◽  
Histopathological Diagnosis ◽  
Oral Lichenoid Lesions ◽  
Number Of Patients ◽  
Preliminary Study ◽  
Mononuclear Infiltrate ◽  
Oral Lichen

Oral lichen planus (OLP) and oral lichenoid lesions (OLL) are clinically and histologically similar lesions but their treatment planning and prognosis are different. The review of the literature indicates numerous criteria to distinguish these two lesions; however there is a lot of inconsistency. Thus, the aim of this study was to determine the correlation of histopathology and clinical OLP and OLL diagnosis and to clarify which histopathologic criteria could best distinguish these two diagnoses. A retrospective study showed that clinically diagnosed 92 OLPs and 14 OLLs have been confirmed histopathologically in 52.2% and 42.9% of cases, respectively. In addition, histopathology showed statistically significant more eosinophils (P<0.0005), plasma cells (P<0.0005), and granulocytes (P<0.05) in OLL than OLP. To establish histopathological diagnosis of OLP and OLL it should be mandatory to define the type of cells in mononuclear infiltrate, which can be associated more accurately with clinical feature and patient history. Therefore, currently accepted diagnostic criteria for OLP and OLL should be modified and validated on a larger number of patients taking into account particular distinguishing histopathological features.

Malignant transformation of oral lichen planus and oral lichenoid lesions: A meta-analysis of 20095 patient data

Oral Oncology ◽  
2017 ◽  
Vol 68 ◽  
pp. 92-102 ◽  
Author(s):  
Sana Maher Hasan Aghbari ◽  
Abdelrahman Ibrahim Abushouk ◽  
Attia Attia ◽  
Ahmed Elmaraezy ◽  
Amr Menshawy ◽  
...  
Keyword(s):  
Malignant Transformation ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Meta Analysis ◽  
Patient Data ◽  
Oral Lichenoid Lesions ◽  
Oral Lichen
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