The Association of rs187238, rs19465518 and rs1946519 IL-8 Polymorphisms with Acute Kidney Injury in Preterm Infants

Objective This study aimed to evaluate the significance of urinary kidney injury molecule-1 (uKIM-1) levels in predicting acute kidney injury (AKI) and mortality in very low birth weight (VLBW) preterm infants. Methods This prospective, observational cohort study was conducted on 39 VLBW preterm infants. Serum creatinine (SCr) and uKIM-1 levels were measured in the first 24 and 48 to 72 hours of life. The estimated glomerular filtration rate (eGFR) was calculated. Levels of uKIM-1 were measured with an enzyme-linked immunosorbent assay. Results Among 39 VLBW infants, 9 (23%) developed AKI. The mortality rate was 17.9% (n = 7 neonates). There was no significant difference in SCr levels, uKIM-1 levels, or the eGFR obtained in the first 24 hours in the AKI group compared with controls. However, significant differences were found in SCr and uKIM-1 levels, and the eGFR rate at 48 to 72 hours between the groups. Levels of uKIM-1 were significantly higher in non-survivors than in survivors in the first 24 and 48 to 72 hours of life. Conclusion The level of uKIM-1 can be used as a simple noninvasive diagnostic method for predicting AKI and mortality, especially within 48 to 72 hours of life. Clinical trial registration: We do not have a clinical trial registration ID. In Turkey, clinical trial registration is not required for non-drug, noninvasive, clinical studies.

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Low Renal Oxygen Saturation at Near-Infrared Spectroscopy on the First Day of Life Is Associated with Developing Acute Kidney Injury in Very Preterm Infants

Neonatology ◽

10.1159/000494462 ◽

2019 ◽

Vol 115 (3) ◽

pp. 198-204 ◽

Cited By ~ 5

Author(s):

Francesco Bonsante ◽

Duksha Ramful ◽

Christine Binquet ◽

Sylvain Samperiz ◽

Sandrine Daniel ◽

...

Keyword(s):

Acute Kidney Injury ◽

Infrared Spectroscopy ◽

Oxygen Saturation ◽

Preterm Infants ◽

Near Infrared Spectroscopy ◽

Near Infrared ◽

Kidney Injury ◽

Very Preterm Infants ◽

Very Preterm ◽

Renal Oxygen

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Changes in Serum Creatinine Levels and Natural Evolution of Acute Kidney Injury with Conservative Management of Hemodynamically Significant Patent Ductus Arteriosus in Extremely Preterm Infants at 23–26 Weeks of Gestation

Journal of Clinical Medicine ◽

10.3390/jcm9030699 ◽

2020 ◽

Vol 9 (3) ◽

pp. 699 ◽

Cited By ~ 2

Author(s):

Eun Seo ◽

Se Sung ◽

So Ahn ◽

Yun Chang ◽

Won Park

Keyword(s):

Acute Kidney Injury ◽

Patent Ductus Arteriosus ◽

Serum Creatinine ◽

Preterm Infants ◽

Ductus Arteriosus ◽

Kidney Injury ◽

Adverse Outcomes ◽

Extremely Preterm ◽

Extremely Preterm Infants ◽

Patent Ductus

Changes in kidney function in extremely preterm infants (EPT) with conservatively managed hemodynamically significant (HS) patent ductus arteriosus (PDA) are not known well. We aimed to present the postnatal course in serum creatinine levels (sCr), prevalence of acute kidney injury (AKI), then relevance between AKI and adverse outcomes in EPT with conservatively managed HS PDA. By review of medical records, we analyzed the postnatal course of sCr and prevalence of stage 3 AKI defined by the modified Kidney Disease Improving Global Outcome (KDIGO) in EPT at gestational age of 23 to 26 weeks with conservatively treated HS PDA. We investigated if the presence and/or prolonged duration of stage 3 AKI elevated the risk of adverse outcomes. The results showed that, neither factor was associated with adverse outcomes. While the average PDA closure date was at postnatal day (P) 41 and 53, sCr peaked at P 10 and 14 and the cumulative prevalence of stage 3 AKI was 57% and 72% in the EPT of 25–26 and 23–24 weeks’ gestation, respectively. The high prevalence of stage 3 AKI without adverse outcomes in EPT with conservatively managed HS PDA suggests that it might reflect renal immaturity rather than pathologic conditions.

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Antenatal Steroids and Acute Kidney Injury in Preterm Infants

American Journal of Perinatology ◽

10.1055/s-0040-1722330 ◽

2021 ◽

Author(s):

Nuran Üstün ◽

Sertac Arslanoglu ◽

Fahri Ovali

Keyword(s):

Acute Kidney Injury ◽

Preterm Infants ◽

Neonatal Intensive Care ◽

Very Low Birth Weight ◽

Tertiary Care ◽

Kidney Injury ◽

Inclusion Criteria ◽

Vlbw Infants ◽

Antenatal Steroids ◽

Key Points

Objective The aim of this study was to identify the effects of antenatal steroids (ANS) on acute kidney injury (AKI) in very low birth weight (VLBW) preterm infants. Study Design We performed a retrospective cohort study of VLBW infants admitted to a tertiary-care neonatal intensive care unit between January 2016 and June 2019. Infants were divided into no ANS, partial ANS, and complete ANS groups. Serum creatinine (SCr) levels and rates of AKI during the first 2 weeks of life were compared. Results During the study period, 335 infants met our inclusion criteria. Among no, partial, and complete ANS groups, there were significant differences in rates of stages 2 and 3 AKI (17, 11, and 6%, respectively). Logistic regression analysis revealed that complete ANS course was associated with lower rates of AKI (odds ratio [OR] = 0.41 95% confidence interval [CI]: 0.20–0.83) and stages 2 and 3 AKI (OR = 0.205 95% CI: 0.075–0.563) compared with no ANS. Infants in complete ANS group had significantly lower SCr at 72 hours of life and at discharge, SCr peak was compared with infants in no ANS group. Conclusion In VLBW infants, complete ANS exposure may be associated with improved renal function and decreased risk for AKI compared with no ANS. Key Points

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Acute kidney injury in the newborn infant: classification, causes and epidemiology

Nephrology (Saint-Petersburg) ◽

10.24884/1561-6274-2019-23-5-9-16 ◽

2019 ◽

Vol 23 (5) ◽

pp. 9-16

Author(s):

D. I. Ivanov ◽

N. D. Savenkova

Keyword(s):

Acute Kidney Injury ◽

Preterm Infants ◽

Very Low Birth Weight ◽

Kidney Injury ◽

Epidemiological Studies ◽

Acute Kidney Injury Network ◽

Kidney Damage ◽

Preterm Neonates ◽

The Status ◽

Development Course

In the article are presented classifications, causes and epidemiology of acute kidney injury (AKI) in newborns, unsolved problems. Neonatal AKI classifications proposed by Acute Kidney Injury Network (2007), JG Jetton, DJ Askenazi (2012), modifications from NKC, KDIGO, and AWAKEN (2016), AKI Workshop (2017) are discussed. The results of the international assessment Assessment of Worldwide Acute Kidney Injury Epidemiology in Neonates (AWAKEN), JG Jetton et al (2016, 2017) are discussed. Of the 2022 babies, 605 (30 %) had the status of AKI: in 48 % of the 273 preterm neonates with gestatoinal age 22-29 weeks; 18 % of 916 preterm neonates with gestatoinal age 29-36 weeks; in 37 % of 833 neonates with gestatoinal age after 36 weeks. The risk factors for the development of early AKI in preterm infants include low gestational age and very low birth weight. According to international epidemiological studies, the development of AKI in premature newborns is the main and independent risk factor for mortality and the formation of chronic kidney disease. The absence of multicenter epidemiological studies of acute kidney damage in newborns in our country is still an unsolved problem. The solution of the problem facing the national neonatology should be aimed at ensuring a unified approach to the classifications of acute kidney damage, on studying epidemiology, features of development, course, and outcome of acute kidney damage of various etiologies, on developing algorithms for prevention, diagnosis and treatment in term and preterm infants.

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EARLY DIAGNOSIS OF ACUTE KIDNEY INJURY IN PRETERM INFANTS USING URINARY NGAL BIOMARKER

Science and Innovations in Medicine ◽

10.35693/2500-1388-2017-0-4-47-52 ◽

2017 ◽

Vol 2 (4) ◽

pp. 47-52

Author(s):

SV V Aborin ◽

DV V Pechkurov ◽

LI I Zakharova

Keyword(s):

Acute Kidney Injury ◽

Early Diagnosis ◽

Preterm Infants ◽

Prognostic Significance ◽

Kidney Injury ◽

Accurate Information ◽

Urinary Ngal ◽

Lipocalin 2 ◽

Ngal Level ◽

Neutrophil Gelatinase Associated Lipocalin

In this study, we evaluated the diagnostic and prognostic value of the neutrophil gelatinase-associated lipocalin-2 (NGAL) level in urine as an early marker of renal dysfunction in preterm infants with very low and extremely low body weight. Aim - evaluation of diagnostic and prognostic significance of the urinary NGAL level as an early biomarker of acute kidney injury (AKI) in preterm infants. Materials and methods. The study included 104 premature babies, 78 of which formed the main group (AKI), and 26 babies - the comparison group (non-AKI). The main criterion for acute kidney injury in neonates according to neonatal classification AKIN (2011) is creatinine level > 1.5 mg/dL at the age of not earlier than 48 hours after birth. Results. The study identified a statistically significant correlation in the level of NGAL in the urine of children from the main and comparison groups. Conclusion. Biomarkers of kidney damage can give more accurate information than creatinine for the early diagnosis of AKI in children. In a comprehensive assessment of a child, it is necessary to take note of the indicators of renal function (creatinine, GFR) and biomarkers of injury (NGAL). This approach will allow performing the diagnostics and therapy of early AKI in children based on structural and functional criteria.

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