scholarly journals High-Resolution Video Tracking of Locomotion in Adult Drosophila Melanogaster.

10.3791/1096 ◽  
2009 ◽  
Author(s):  
Justin B. Slawson ◽  
Eugene Kim ◽  
Leslie C. Griffith
Keyword(s):  
Drosophila Melanogaster ◽  
High Resolution ◽  
Video Tracking ◽  
Adult Drosophila

scholarly journals A High-Resolution Whole-Genome Map of Key Chromatin Modifications in the Adult Drosophila melanogaster

PLoS Genetics ◽  
2011 ◽  
Vol 7 (12) ◽  
pp. e1002380 ◽  
Author(s):  
Hang Yin ◽  
Sarah Sweeney ◽  
Debasish Raha ◽  
Michael Snyder ◽  
Haifan Lin
Keyword(s):  
Drosophila Melanogaster ◽  
High Resolution ◽  
Whole Genome ◽  
Chromatin Modifications ◽  
Genome Map ◽  
Adult Drosophila

HRSiam: High-Resolution Siamese Network, Towards Space-Borne Satellite Video Tracking

2021 ◽  
Vol 30 ◽  
pp. 3056-3068
Author(s):  
Jia Shao ◽  
Bo Du ◽  
Chen Wu ◽  
Mingming Gong ◽  
Tongliang Liu
Keyword(s):  
High Resolution ◽  
Video Tracking ◽  
Siamese Network

scholarly journals Effect of a Dipeptide-Enriched Diet in an Adult Drosophila melanogaster Laboratory Strain

2013 ◽  
Vol 77 (4) ◽  
pp. 836-838 ◽  
Author(s):  
Shigenobu SHIOTANI ◽  
Nobuya YANAI ◽  
Takanori SUZUKI ◽  
Shiho TUJIOKA ◽  
Yurie SAKANO ◽  
...  
Keyword(s):  
Drosophila Melanogaster ◽  
Laboratory Strain ◽  
Adult Drosophila

Towards a Drosophila model of Hutchinson–Gilford progeria syndrome

2008 ◽  
Vol 36 (6) ◽  
pp. 1389-1392 ◽  
Author(s):  
Gemma S. Beard ◽  
Joanna M. Bridger ◽  
Ian R. Kill ◽  
David R.P. Tree
Keyword(s):  
Drosophila Melanogaster ◽  
Premature Aging ◽  
Lamin A ◽  
Wild Type ◽  
Drosophila Model ◽  
Numerous Cell ◽  
Cellular Abnormalities ◽  
Progeria Syndrome ◽  
Hutchinson Gilford Progeria Syndrome ◽  
Adult Drosophila

The laminopathy Hutchinson–Gilford progeria syndrome (HGPS) is caused by the mutant lamin A protein progerin and leads to premature aging of affected children. Despite numerous cell biological and biochemical insights into the basis for the cellular abnormalities seen in HGPS, the mechanism linking progerin to the organismal phenotype is not fully understood. To begin to address the mechanism behind HGPS using Drosophila melanogaster, we have ectopically expressed progerin and lamin A. We found that ectopic progerin and lamin A phenocopy several effects of laminopathies in developing and adult Drosophila, but that progerin causes a stronger phenotype than wild-type lamin A.

scholarly journals Multi-enhancer transcriptional hubs confer phenotypic robustness

eLife ◽  
2019 ◽  
Vol 8 ◽  
Author(s):  
Albert Tsai ◽  
Mariana RP Alves ◽  
Justin Crocker
Keyword(s):  
Transcription Factor ◽  
Drosophila Melanogaster ◽  
High Resolution ◽  
Elevated Temperatures ◽  
Regulatory Region ◽  
Deletion Allele ◽  
Genetic Perturbations ◽  
Transcription Sites ◽  
Phenotypic Robustness ◽  
Transcriptional Output

We previously showed in Drosophila melanogaster embryos that low-affinity Ultrabithorax (Ubx)-responsive shavenbaby (svb) enhancers drive expression using localized transcriptional environments and that active svb enhancers on different chromosomes tended to colocalize (Tsai et al., 2017). Here, we test the hypothesis that these multi-enhancer ‘hubs’ improve phenotypic resilience to stress by buffering against decreases in transcription factor concentrations and transcriptional output. Deleting a redundant enhancer from the svb locus led to reduced trichome numbers in embryos raised at elevated temperatures. Using high-resolution fluorescence microscopy, we observed lower Ubx concentration and transcriptional output in this deletion allele. Transcription sites of the full svb cis-regulatory region inserted into a different chromosome colocalized with the svb locus, increasing Ubx concentration, the transcriptional output of svb, and partially rescuing the phenotype. Thus, multiple enhancers could reinforce a local transcriptional hub to buffer against environmental stresses and genetic perturbations, providing a mechanism for phenotypical robustness.

scholarly journals High Resolution Mapping of Candidate Alleles for Desiccation Resistance in Drosophila melanogaster under Selection

2011 ◽  
Vol 29 (5) ◽  
pp. 1335-1351 ◽  
Author(s):  
Marina Telonis-Scott ◽  
Madeleine Gane ◽  
Sarah DeGaris ◽  
Carla M. Sgrò ◽  
Ary A. Hoffmann
Keyword(s):  
Drosophila Melanogaster ◽  
High Resolution ◽  
Desiccation Resistance ◽  
High Resolution Mapping ◽  
Resolution Mapping

High-resolution AP-SMALDI mass spectrometry imaging of Drosophila melanogaster

2017 ◽  
Vol 416 ◽  
pp. 1-19 ◽  
Author(s):  
S.M. Khalil ◽  
J. Pretzel ◽  
K. Becker ◽  
B. Spengler
Keyword(s):  
Mass Spectrometry ◽  
Drosophila Melanogaster ◽  
High Resolution ◽  
Mass Spectrometry Imaging
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