Background:
Peptide nucleic acids (PNAs) belong to the next generation of synthetic nucleic acid
analogues. Their high binding affinity and specificity towards the target DNA or RNA make them the reagent of
choice for gene therapy-based applications.
Objective:
To review important gene therapy based applications of regular and chemically modified peptide nucleic
acids in combination with nanotechnology.
Method:
Selective research of the literature.
Results:
Poor intracellular delivery of PNAs has been a significant challenge. Among several delivery strategies
explored till date, nanotechnology-based strategies hold immense potential. Recent studies have shown that advances
in nanotechnology can be used to broaden the range of therapeutic applications of PNAs. In this review,
we discussed significant advances made in nanoparticle-based on PLGA polymer, silicon, oxidized carbon and
graphene oxide for the delivery of PNAs.
Conclusion:
Nanoparticles delivered PNAs can be implied in diverse gene therapy based applications including
gene editing as well as gene targeting (antisense) based strategies.
Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids
