Assessment of the quality of life of breast cancer patients after one year of treatment

2021 ◽  
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Cancer Patients ◽  
Cross Sectional Study ◽  
Breast Cancer Patients ◽  
Related Factors ◽  
Cross Sectional ◽  
Life Score ◽  
One Year

Introduction: Breast cancer is the most commonly diagnosed malignancy and the leading cause of death among women worldwide. The incidence of breast cancer is on the rise in developing countries. Breast cancer patients not only experience physical pain from treatment but may also face mental crises, impaired social function, and impaired quality of life. However, there are not many studies on the quality of life (QoL) of post - treatment breast cancer patients. Therefore, we carried out the study “assessment the quality of life of breast cancer patients after one year of treatment” with aims to evaluate the quality of life of breast cancer patients after one year of treatment using the scales EQ-5D-5L and QLQ-BR23 and to find out related factors to the quality of life of these subjects. Methods: A cross - sectional study was conducted on 100 breast cancer patients after one year of treatment at the Hue University of Medicine and Pharmacy Hospital to examine the quality of life using the scales EQ-5D-5L and QLQ-BR23 and to detect the associated factors. Results: The mean quality of life score of breast cancer patients after one year of treatment on the EQ- 5D-5L scale was 0.6436 ± 0.2098. By QLQ-BR23, the quality of life score on function was 74.75 ± 20.78 while the score on symptoms was 28.80 ± 12.79. The quality of life from both scales was found to be statistically significant related to social work participation, self - reported health, risk of depression, anxiety, and stress. Conclusions: The quality of life of breast cancer patients in the study was at a moderate level. This suggests more supports to be done continuously after long - term post - diagnosing especially psychological and social aspects for these subjects.

scholarly journals Quality of Life of Breast Cancer Patients in Amhara Region, Ethiopia: A Cross-Sectional Study

2020 ◽  
Author(s):  
Tamrat Alem ◽  
Dabere Nigatu ◽  
Amsalu Birara ◽  
Tamene Fetene ◽  
Mastewal Giza
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Cancer Patients ◽  
Associated Factors ◽  
Cross Sectional Study ◽  
Breast Cancer Patients ◽  
Sectional Study ◽  
Amhara Region ◽  
Cross Sectional

Abstract BackgroundAlthough breast cancer has a markedly higher incidence in developed countries, 50% of the new diagnosis and 70% of deaths occur in developing countries. There are limited data available on the quality of life among breast cancer patients in Ethiopia, notably in the Amhara region. This study aimed to assess the quality of life and associated factors among patients with breast cancer in the Amhara Region, Ethiopia, 2019.MethodsInstitutional based cross-sectional study was conducted from March 25 to July 7/2019 among 256 patients with breast cancer in the Amhara region. A systematic random sampling technique was used. Data were collected by using a standardized interviewer-administered Amharic version of the European Organization for research and treatment of cancer quality of life questionnaire core 30(EORTC QLQ C30) and breast cancer supplementary measure (QLQ-BR23). Data were analyzed by SPSS version 23. A binary logistic regression model was fitted to identify the associated factors. The odds ratio (OR) with 95% confidence interval (CI) was used to measure the strength of association.ResultsSixty-eight point four percent (68.4%) of breast cancer patient's QoL was poor. The mean score of quality of life was 70.6(standard deviation (SD) ±13.9; 95% CI: 69.0-72.4). All functional component scores were less than 75, from the symptom scale; diarrhea (11.6), constipation (17.5), and dyspnea (24.7) were less noticeable. Unmarried patients (AOR=2.59, 95% CI: 1.32-5.07), poor (AOR=2.39, 95%CI: 1.32-5.03), non housewife (AOR=3.25, 95% CI: 1.16-7.22), and complaints to dyspnea (AOR=3.48, 95% CI: 1.79-6.79), and insomnia (AOR=2.03, 95% CI: 1.05-3.91) were significantly associated with quality of life.ConclusionsHealth care professionals should give attention to unmarried, and non-housewife breast cancer patients, besides the treatment to improve the health of breast cancer patients.

scholarly journals Quality of life among breast cancer patients: a cross sectional study

2017 ◽  
Vol 4 (3) ◽  
pp. 686
Author(s):  
Jeseena Kanayamkandi ◽  
Shalini Sunderam
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Cancer Patients ◽  
Economic Status ◽  
Total Duration ◽  
Cross Sectional Study ◽  
Breast Cancer Patients ◽  
Cross Sectional ◽  
Hindu Religion

Background: Breast cancer is the most common cancer in women globally. Over the last decade, Quality of life (QOL) has become an important outcome measure in the treatment of cancer patients. Aim and Objective-.1) To evaluate the Quality of life among Breast cancer patients; 2) To describe the socio-demographic profile of Breast cancer patients; 3) To find out association between socio-demographic characteristics of patients and Quality of life.Methods: It was a cross sectional, descriptive and hospital based study. Total duration of study was 6 months (April 2015-September 2015), conducted in Rajendra Institute of Medical Sciences (RIMS), Ranchi, Jharkhand 84 breast cancer patients were selected as study subjects and were interviewed by a validated questionnaire.Results: A total of 84 breast cancer patients were included in the study, most of the patients were between 40-60 years, mean age being 43.32±10.2. Most were non tribal, belonging to Hindu Religion. Majority were married. None of the participants had above average or significantly high QOL. 20.2% had average QOL, 51.2% had below average and 28.6% had significantly poor QOL. Married patients were found to have a significantly better QOL (p<0.05). QOL had no association with age, ethnicity, religion, education, occupation or socio-economic status of participants (p>0.05).Conclusions: Present study showed that majority of Breast cancer patients had poor QOL. Married patients were leading a comparatively better QOL than unmarried. 

scholarly journals Effect of Inhibited T lymphocyte Function on Depressive Symptoms in Breast Cancer Patients with Depression

2021 ◽  
Author(s):  
Jun-He Zhou ◽  
Wei-Han Li ◽  
De-Long Zhang ◽  
Bai-Le Ning ◽  
Lin Zhao ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
T Lymphocytes ◽  
Cancer Patients ◽  
T Lymphocyte ◽  
Structural Equations ◽  
Lymphocyte Function ◽  
Breast Cancer Patients ◽  
Cross Sectional

Abstract Background: Depression has a high incidence among patients with breast cancer, but the relationship between depression and cancer-related physiological changes is not clear.Objectives: To explore the effect of T lymphocytes on breast cancer depression and the patient’s quality of life.Methods: This is a cross-sectional study. A total of 93 breast cancer patients with depression were recruited, 46 of whom underwent T lymphocyte, cortisol, BDNF, TNF-α, and IL-1β collection. We analysed the correlation between the indicators in these 46 participants and constructed two intermediary structural equations between their T lymphocytes and depression, as well as their T lymphocytes and their quality of life.Results: The results showed that CD4+ had a positive correlation with BDNF (r=0.334, P=0.023) and that BDNF had a negative correlation with HAMD-24 (r=-0.390, P=0.007). Both CD3+ and CD8+ cells were negatively correlated with cortisol (r=-0.358, P=0.015, r=-0.411, P=0.005), and cortisol was positively correlated with FACT-B (r=0.435, P=0.003). The equations including CD4+, BDNF, and HAMD-24, as well as the equations including CD3+, CD8+, cortisol, and FACT-B, were established. BDNF was the mediating variable between CD4+ and HAMD-24. Cortisol was the mediating variable between CD3+, CD8+ and FACT-B. Neither HAMD-24 nor FACT-B could form a direct path with T lymphocytes.Conclusion: T lymphocytes may be involved in the depression of breast cancer patients since a poor quality of life could inhibit T lymphocytes, and this may be the underlying physiological cause of breast cancer-related depression.

scholarly journals Clinical and genetic factors associated with anxiety and depression in breast cancer patients: a cross-sectional study

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Aline HAJJ ◽  
Roula HACHEM ◽  
Rita KHOURY ◽  
Souheil HALLIT ◽  
Bashar ElJEBBAWI ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Sleep Quality ◽  
Cancer Patients ◽  
Genetic Factors ◽  
Cross Sectional Study ◽  
Anxiety And Depression ◽  
Breast Cancer Patients ◽  
Sectional Study ◽  
Cross Sectional

Abstract Background Despite the progress in assessment and treatment of breast cancer, being diagnosed with it or receiving chemotherapy treatment is still conceived as a traumatic experience. Women develop negative thoughts about life and death with detrimental effects on their daily physical functioning/activities, emotional state and overall quality of life. The aim of our study was to evaluate the level of anxiety and depression among breast cancer patients receiving chemotherapy and explore the correlation between these psychological disorders, clinical, sociodemographic and genetic factors. Methods A cross-sectional study was conducted among breast cancer patients undergoing intravenous chemotherapy at the oncology outpatient unit of Hôtel-Dieu de France hospital (November 2017–June 2019; Ethical approval number: CEHDF1016). All patients gave their written informed consent and completed several validated scales, including the Hospital Anxiety and Depression scale (HADS) for the assessment of anxiety and depression. Sleep quality, insomnia, cognitive function, fatigue and pain were also evaluated. Genotyping for certain gene polymorphisms (CLOCK, PER2, CRY2, OPRM1, ABCB1, COMT, DRD2) was performed using the Lightcycler® (Roche). Results A total of 112 women was included. The prevalence of depression was 43.4%, and 56.2% of the patients reported anxiety (based on the HADS classification). Multivariable analysis showed that higher cognitive scores and taking fosaprepitant were significantly associated with lower depression and anxiety scores. Moreover, being married compared to single was also associated with lower depression scores, whereas higher PSQI scores (worse sleep quality) and having the PER2 AA variant genotype compared to GG were significantly associated with higher depression scores. Finally, reporting a more severe insomnia and having the COMT Met/Met genotype were significantly associated with a higher anxiety score. Conclusions Our study demonstrated a strong relationship between depression scores and cognitive impairment, sleep quality, marital status, fosaprepitant intake, and PER2 polymorphism, while anxiety scores were correlated to cognitive impairment, insomnia severity, fosaprepitant intake, and COMT polymorphism. The association with PER polymorphism was not previously reported. Identification of genetic and clinical risk factors for anxiety and depression would help clinicians implement an individualized management therapy aiming at preventing and alleviating the burden of these symptoms in breast cancer patients, hence improving their overall quality of life.

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