Characterization of mouse cytochrome P450-catalyzed Oxidative metabolism of rutaecarpine, an alkaloid in the herbal medicine evodia rutaecarpa

2020 ◽  
Vol 14 (2) ◽  
Author(s):  
W.-C. Jan ◽  
M.-J. Don ◽  
L.-K. Ho ◽  
C.-F. Chen ◽  
Y.-F. Ueng
Keyword(s):  
Cytochrome P450 ◽  
Herbal Medicine ◽  
Oxidative Metabolism ◽  
Evodia Rutaecarpa

scholarly journals Identification of the cytochrome P450 enzymes involved in the oxidative metabolism of trantinterol using ultra high-performance liquid chromatography coupled with tandem mass spectrometry

RSC Advances ◽  
2018 ◽  
Vol 8 (60) ◽  
pp. 34764-34772
Author(s):  
Kunjie Li ◽  
Xingjie Guo ◽  
Feng Qin ◽  
Zhili Xiong ◽  
Longshan Zhao ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
High Performance Liquid Chromatography ◽  
Cytochrome P450 ◽  
Liquid Chromatography ◽  
Tandem Mass Spectrometry ◽  
Oxidative Metabolism ◽  
High Performance ◽  
Tandem Mass ◽  
Cytochrome P450 Enzymes

The first report on the characterization of the main CYP450 enzymes and the kinetic study involved in trantinterol metabolism.

Purification and Characterization of Cytochrome P450 from an Isobutene-forming Microorganism,Rhodotorula minuta

1993 ◽  
Vol 57 (9) ◽  
pp. 1599-1601 ◽  
Author(s):  
Hideo Fukuda ◽  
Takao Fujii ◽  
Hironori Daimon ◽  
Makoto Iwata ◽  
Takahira Ogawa ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Purification And Characterization ◽  
Rhodotorula Minuta

Characterization of Diuron N-Demethylation by Mammalian Hepatic Microsomes and cDNA-Expressed Human Cytochrome P450 Enzymes

2007 ◽  
Vol 35 (9) ◽  
pp. 1634-1641 ◽  
Author(s):  
Khaled Abass ◽  
Petri Reponen ◽  
Miia Turpeinen ◽  
Jorma Jalonen ◽  
Olavi Pelkonen
Keyword(s):  
Cytochrome P450 ◽  
Cytochrome P450 Enzymes ◽  
Hepatic Microsomes ◽  
Human Cytochrome

Increased serum drug concentrations in concomitant treatment with citalopram, clomipramine and alprazolam

1994 ◽  
Vol 9 (6) ◽  
pp. 312-314
Author(s):  
U Lepola ◽  
E Leinonen ◽  
H Koponen
Keyword(s):  
Cytochrome P450 ◽  
Major Depression ◽  
Obsessive Compulsive Disorder ◽  
Oxidative Metabolism ◽  
Competitive Inhibition ◽  
High Serum ◽  
Concomitant Treatment ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Drug Concentrations

SummaryWe report the case of a patient with major depression and obsessive-compulsive disorder who had simultaneously high serum citalopram, clomipramine, and alprazolam concentrations probably due to the reciprocal competitive inhibition of the cytochrome P450-catalyzed oxidative metabolism.

Characterization of cytochrome P450-monooxygenases of Chinese hamsters with respect to aflatoxin B1 activation

Toxicology ◽  
1994 ◽  
Vol 93 (2-3) ◽  
pp. 165-173 ◽  
Author(s):  
Morio Fukuhara ◽  
Eric Antignac ◽  
Naomi Fukusen ◽  
Kazue Kato ◽  
Masanobu Kimura
Keyword(s):  
Cytochrome P450 ◽  
Aflatoxin B1 ◽  
Cytochrome P450 Monooxygenases ◽  
P450 Monooxygenases ◽  
Chinese Hamsters
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