IDH1 Mutation in Gliomas in Mosul City - Iraq

BACKGROUND: IDH1 (isocitrate dehydrogenase 1) mutation might be encounter in the low grade glioma and directs the progression of the tumor to a higher grade.OBJECTIVE: To assess the frequency of IDH1 mutations in gliomas and to correlate the IDH1 positivity with the type and grade of tumors, the age and sex of the patients.MATERIAL AND METHODS: A retro– and prospective case series study. One hundred and nine cases of intracranial gliomas were collected between 2008 and 2014 from Mosul Private Laboratories and Al-Jamboree Teaching Hospitals in Mosul. IDH1 mutations were assessed immunohistochemically using anti-IDH1 R132H mouse monoclonal antibody.RESULTS: IDH1 mutation was perceived in 34.86% of gliomas. In adult gliomas, the secondary glioblastoma and the low-grade astrocytoma had the greatest values of IDH1 positivity (88.88% and 62.5% respectively), followed by oligoastrocytoma/oligodendroglioma (50.0%), and anaplastic astrocytoma (47.36%). The primary glioblastomsa showed 17.64% IDH1 positivity. Males and females expressed the IDH1 equally. While, there was no role of IDH1 in pediatric gliomas.CONCLUSION: IDH1 mutation is commonly present in adult gliomas particularly in low-grade gliomas, and secondary glioblastoma, with equal sex distribution, but it has no role in pediatric gliomas.

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Reinke's oedema, hormones and hormone replacement therapy

The Journal of Laryngology & Otology ◽

10.1017/s0022215106001630 ◽

2006 ◽

Vol 120 (10) ◽

pp. 849-852 ◽

Cited By ~ 1

Author(s):

A Tsikoudas ◽

X Kochillas ◽

G Vernham

Keyword(s):

Hormone Replacement Therapy ◽

Replacement Therapy ◽

Thyroid Function ◽

Hormone Replacement ◽

Case Series ◽

Teaching Hospitals ◽

Thyroid Function Tests ◽

Female Population ◽

Case Series Study ◽

Prospective Case Series

Objective: To study the implications of hormone replacement therapy (HRT) treatment in the pathogenesis of Reinke's oedema (via a possible pseudo-hypothyroidism effect), and also to study why the disease affects a predominantly post-menopausal female population.Design: Prospective case series study.Setting: Two teaching hospitals and two district general hospitals in Scotland, UK.Subjects: Thirty-three patients diagnosed with Reinke's oedema who presented in the out-patient department before or after treatment.Results: Thyroid function tests were normal in all but two cases. Only three patients were receiving HRT treatment.Conclusions: The study produced no evidence to support a relationship between HRT treatment and the pathogenesis of Reinke's oedema; this supports previous studies which concluded that thyroid function was not related to the development of Reinke's oedema. Some new ideas regarding hormonal factors in Reinke's oedema are discussed.

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IDH1 Non-Canonical Mutations and Survival in Patients with Glioma

Diagnostics ◽

10.3390/diagnostics11020342 ◽

2021 ◽

Vol 11 (2) ◽

pp. 342 ◽

Cited By ~ 1

Author(s):

Enrico Franceschi ◽

Dario De Biase ◽

Vincenzo Di Nunno ◽

Annalisa Pession ◽

Alicia Tosoni ◽

...

Keyword(s):

Idh1 Mutation ◽

Who Grade ◽

Tissue Samples ◽

1P19q Codeletion ◽

Idh1 R132h ◽

Rare Mutations ◽

Grade Ii ◽

Idh1 Mutations ◽

R132h Mutation ◽

Generation Sequencing

Background: Non-canonical mutations of the isocitrate dehydrogenase (IDH) genes have been described in about 20–25% and 5–12% of patients with WHO grade II and III gliomas, respectively. To date, the prognostic value of these rare mutations is still a topic of debate. Methods: We selected patients with WHO grade II and III gliomas and IDH1 mutations with available tissue samples for next-generation sequencing. The clinical outcomes and baseline behaviors of patients with canonical IDH1 R132H and non-canonical IDH1 mutations were compared. Results: We evaluated 433 patients harboring IDH1 mutations. Three hundred and ninety patients (90.1%) had a canonical IDH1 R132H mutation while 43 patients (9.9%) had a non-canonical IDH1 mutation. Compared to those with the IDH1 canonical mutation, patients with non-canonical mutations were younger (p < 0.001) and less frequently presented the 1p19q codeletion (p = 0.017). Multivariate analysis confirmed that the extension of surgery (p = 0.003), the presence of the 1p19q codeletion (p = 0.001), and the presence of a non-canonical mutation (p = 0.041) were variables correlated with improved overall survival. Conclusion: the presence of non-canonical IDH1 mutations could be associated with improved survival among patients with IDH1 mutated grade II–III glioma.

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NCOG-38. CLINICAL CHARACTERISTICS OF LOW GRADE GLIOMA PATIENTS WITH NON-CANONICAL IDH1 AND IDH2 MUTATIONS

Neuro-Oncology ◽

10.1093/neuonc/noaa215.576 ◽

2020 ◽

Vol 22 (Supplement_2) ◽

pp. ii137-ii137

Author(s):

Katherine Peters ◽

Eric Lipp ◽

Gloria Broadwater ◽

James Herndon ◽

Margaret Johnson ◽

...

Keyword(s):

Clinical Characteristics ◽

Point Mutations ◽

Progression Free Survival ◽

Idh1 Mutation ◽

Low Grade ◽

Isocitrate Dehydrogenase 1 ◽

Who Grade ◽

Targeted Mutation ◽

Kaplan Meier ◽

Idh1 And Idh2 Mutations

Abstract BACKGROUND Low grade gliomas (LGGs) develop in young adults and represent 10-15% of all glial tumors. While LGG patients can have longer survival than higher grade tumors, progression, transformation, and ultimately mortality occurs. Mutations in Isocitrate dehydrogenase 1/2 (IDH1/IDH2) are prevalent in LGG and are responsible for gliomagenesis. The classic IDH1 mutation is located at 132 codon and represented as p.Arg132His, but there are non-canonical IDH1 and IDH2 mutations. We sought to compare clinical characteristics of LGG patients with classic IDH1 p.Arg132His mutation to LGG patients with non-canonical IDH1 and IDH2 mutations. METHODS We queried an IRB-approved registry retrospectively from 12/2004- 9/2019. We included IDH1/IDH2 mutant LGG (WHO grade II) and known IDH1 and IDH2 targeted mutation analysis using standard PCR followed by DNA sequencing to detect point mutations in IDH1/IDH2 genes. We obtained available clinical and histopathological data. We estimated progression-free survival (PFS), time to transformation (TT), and overall survival (OS) using Kaplan-Meier methods. RESULTS We identified 267 LGG patients with median follow-up of 9.1 yrs (95%CI 8.4-9.9 yrs). Classic IDH1 p.Arg132His mutation occurred in 223 (83.9%) patients. IDH2 mutations occurred in 14 (5.2%) patients. Non-canonical IDH1 mutations were in 30 (11.2%) patients and included the following mutations: p.Arg132Cys (13), p.Arg132Gly (10), p.Arg132Ser (4), p.Arg132Leu (1), p.Arg119Gln (1), and p.Arg172Met (1). Initial presentation, OS, and TT did not differ between IDH1/IDH2 groups. PFS differed significantly between groups with improved median PFS in IDH2 mutant LGG (5.4 yrs; 95%CI 3.5-25.2) versus classic IDH1 mutant LGG (4.1 yrs; 95%CI 3.7-4.9 yrs) and non-canonical IDH1 mutant LGG (2.6 yrs; 95%CI 2.1-4.8) (log-rank p=0.019). Notably, non-canonical mutations were more common in astrocytoma (22/30; 73.3%) than other LGG histologies (p=0.018). CONCLUSIONS In this cohort, LGG patients with non-canonical mutations have a shorter time to progression than patients with classic p.Arg132His mutation and IDH2 mutations.

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The Effect of HbA1c Variability as a Risk Measure for Microangiopathy in Type 1 Diabetes Mellitus

Diagnostics ◽

10.3390/diagnostics11071151 ◽

2021 ◽

Vol 11 (7) ◽

pp. 1151

Author(s):

Pedro Romero-Aroca ◽

Raul Navarro-Gil ◽

Albert Feliu ◽

Aida Valls ◽

Antonio Moreno ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Diabetic Retinopathy ◽

Type 1 Diabetes Mellitus ◽

Risk Measure ◽

Case Series ◽

Multivariate Statistical ◽

Case Series Study ◽

Prospective Case Series

Background: To measure the relationship between variability in HbA1c and microalbuminuria (MA) and diabetic retinopathy (DR) in the long term. Methods: A prospective case-series study, was conducted on 366 Type 1 Diabetes Mellitus patients with normoalbuminuria and without diabetic retinopathy at inclusion. The cohort was followed for a period of 12 years. The Cox survival analysis was used for the multivariate statistical study. The effect of variability in microangiopathy (retinopathy and nephropathy) was evaluated by calculating the standard deviation of HbA1c (SD-HbA1c), the coefficient of variation of HbA1c (CV-HbA1c), average real variability (ARV-HbA1c) and variability irrespective of the mean (VIM-HbA1c) adjusted for the other known variables. Results: A total of 106 patients developed diabetic retinopathy (29%) and 73 microalbuminuria (19.9%). Overt diabetic nephropathy, by our definition, affected only five patients (1.36%). Statistical results show that the current age, mean HbA1c, SD-HbA1c and ARV-HbA1c are significant in the development of diabetic retinopathy. Microalbuminuria was significant for current age, mean HbA1c, CV-HbA1c and ARV-HbA1c. Conclusions: By measuring the variability in HbA1c, we can use SD-HbA1c and ARV-HbA1c as possible targets for judging which patients are at risk of developing DR and MA, and CV-HbA1c as the target for severe DR.

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High-power diode laser in the circumvestibular incision for Le Fort I osteotomy in orthognathic surgery: a prospective case series study

Lasers in Medical Science ◽

10.1007/s10103-017-2333-4 ◽

2017 ◽

Vol 33 (1) ◽

pp. 51-56 ◽

Cited By ~ 3

Author(s):

Filipe Jaeger ◽

Gustavo Marques Chiavaioli ◽

Guilherme Lacerda de Toledo ◽

Belini Freire-Maia ◽

Marcio Bruno Figueiredo Amaral ◽

...

Keyword(s):

Orthognathic Surgery ◽

Case Series ◽

Le Fort I Osteotomy ◽

Le Fort ◽

Case Series Study ◽

Prospective Case Series ◽

Power Diode ◽

Series Study ◽

High Power Diode Laser ◽

Le Fort I

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Is it a must to tenotomize the biceps intraarticular origin during tenodesis? A prospective case series study of biceps tenodesis without tenotomy

Current Orthopaedic Practice ◽

10.1097/bco.0000000000000963 ◽

2021 ◽

Vol Publish Ahead of Print ◽

Author(s):

Amr Abdel-Mordy Kandeel

Keyword(s):

Case Series ◽

Biceps Tenodesis ◽

Case Series Study ◽

Prospective Case Series ◽

Series Study

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Treatment strategies for inverted papillomas with intracranial or intraorbital involvement

The Journal of Laryngology & Otology ◽

10.1017/s0022215121002152 ◽

2021 ◽

pp. 1-7

Author(s):

D Spinos ◽

T Kalamatianos ◽

D Terzakis ◽

M Piagkou ◽

C Georgalas

Keyword(s):

Demographic Data ◽

Treatment Strategies ◽

Case Series ◽

Recurrence Rates ◽

Case Series Study ◽

Patient Demographic Data ◽

Complete Tumour ◽

Prospective Case Series ◽

Benign Tumours ◽

Inverted Papillomas

Abstract Objective Sinonasal inverted papillomas are challenging benign tumours of the nasal cavity because of their high recurrence rates and the lifetime malignant transformation risk of 10 per cent as well as their locally aggressive behaviour. This study aimed to describe treatment strategies for inverted papillomas with intracranial or intraorbital involvement. Method This was a prospective case series study of 18 patients with inverted papilloma with intracranial or intraorbital involvement. Patient demographic data, imaging, pathology, surgical technique and recurrences were recorded prospectively over a period of seven years. Results A total of 83 per cent of the patients in this study had been previously operated on, consisting of 8 cases with intracranial involvement, 1 case with intraorbital involvement and 9 with both. During follow up with a medium of 37 months (range, 13–115 months) there were two recurrences. Conclusion It was postulated that intracranial or intraorbital involvement observed in this series was the result of multiple revisions. However, using accurate imaging protocols and the pedicle-oriented approach for tumour excision, complete tumour removal was achieved in most cases with minimal post-operative complications.

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