scholarly journals Comparison of Platelet to Lymphocyte Ratio between Degrees of the Barcelona Clinic Liver Cancer on Hepatocellular Carcinoma Patients at Haji Adam Malik General Hospital

2019 ◽  
Vol 7 (20) ◽  
pp. 3451-3454 ◽  
Author(s):  
Gontar Alamsyah Siregar ◽  
Dedi Irwansyah
Keyword(s):  
Hepatocellular Carcinoma ◽  
Retrospective Study ◽  
Prognostic Factor ◽  
Liver Cancer ◽  
General Hospital ◽  
Inflammatory Marker ◽  
Barcelona Clinic Liver Cancer ◽  
Platelet To Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Common Malignancy

BACKGROUND: Hepatocellular carcinoma (HCC) is the fifth most common malignancy. The Barcelona Clinical Liver Cancer System (BCLC), guides the treatment of patients with HCC. Platelet to lymphocyte ratio (PLR) is an inflammatory marker used as a prognostic factor disease of HCC. An increase in PLR indicates higher host's inflammatory response and is associated with aggressive HCC behaviour, according to BCLC. AIM: This study aims to determine the PLRs between among the degrees of BCLC (The Barcelona Clinic Liver Cancer) in HCC patients at Haji Adam Malik General Hospital in Medan during 2015-2016. METHODS: This retrospective study involved 166 patients with HCC who were then classified by the BCLC guidelines. PLRs among the patient's degrees of BCLC were compared using Kruskal Wallis test. RESULTS: A total of 166 HCC patients, 129 (77.7%) were men and 37 (22.3%) were women. The PLR value ​​has a median value of 17841with the lowest value of 1776 and the highest value of 223684. There were differences in PLR levels with various BCLC stages in patients with HCC at Haji Adam Malik Hospital during 2015-2016 (p = 0.026). CONCLUSION: There were differences in PLR levels with various BCLC stages in patients with HCC at Haji Adam Malik Hospital during 2015-2016.

scholarly journals Role of platelet to lymphocyte ratio in assessing prognosis in acute pancreatitis

2019 ◽  
Vol 6 (3) ◽  
pp. 853
Author(s):  
Challapalli Srikanth Reddy ◽  
Keerthinmayee Karimaddela ◽  
Peddavenkatagari Theja ◽  
Gandikota Venkata Prakash ◽  
Pustela Mahesh Kumar
Keyword(s):  
Acute Pancreatitis ◽  
Prognostic Factor ◽  
Mortality Rate ◽  
Early Stage ◽  
Average Length ◽  
Inflammatory Marker ◽  
Cost Effective ◽  
Platelet To Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Resource Setting

Background: Acute pancreatitis is a common condition associated with morbidity and mortality. The incidence of acute pancreatitis (AP) has been increasing worldwide. Recent advances in diagnostic and therapeutic management in acute pancreatitis (AP) remarkably decreased the mortality rate. Assessing severity of acute pancreatitis at an early stage will further decrease the mortality rate and will help to initiate appropriate treatment as early as possible to prevent mortality. Many clinical, laboratory, and radiological factors and scoring systems are used to predict severity and prognosis of AP, but none is ideal. In low resource setting, costly laboratory tests are not readily available.  Platelet to lymphocyte ratio (PLR) is an easily derivable, cost effective and applicable blood test. Platelet to lymphocyte ratio (PLR) is a relatively novel inflammatory marker and can predict severity in various diseases. In this study, we evaluated the value of PLR as prognostic factor in acute pancreatitis (AP).Methods: This prospective study was conducted on 256 patients admitted to S.V.R.R.G.G. Hospital, with the diagnosis of acute pancreatitis, from April 2017 to September 2018. Patients with Acute Pancreatitis were divided into tertiles based on the values of PLR at admission, a PLR of less than 150 as 1st tertile, a PLR of 150-300 as 2nd tertile and a PLR of more than 300 as 3rd tertile. The outcomes assessed were intensive care unit (ICU) admission, length of stay (LOS) in the hospital and death.Results: According to PLR tertiles, patients in the 3rd tertile (PLR>300) had significantly more ICU admissions, 59 (71%) and longer average Length of Hospital Stay (LOS) of survivors,18+/-5 days and higher mortality, 24 (28.9%), compared with those in the 1st tertile (PLR<150).Conclusions: PLR is an easily derivable, cost effective prognostic factor which can predict the outcome of acute pancreatitis. In this study, we established that high PLR value is associated with very bad prognosis and poor outcome or death in Acute pancreatitis.

Platelet-to-lymphocyte ratio acts as a prognostic factor for patients with advanced hepatocellular carcinoma

Tumor Biology ◽  
2014 ◽  
Vol 36 (4) ◽  
pp. 2263-2269 ◽  
Author(s):  
Xing Li ◽  
Zhan-Hong Chen ◽  
Yan-Fang Xing ◽  
Tian-Tian Wang ◽  
Dong-Hao Wu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Prognostic Factor ◽  
Advanced Hepatocellular Carcinoma ◽  
Platelet To Lymphocyte Ratio ◽  
Lymphocyte Ratio

scholarly journals The prognostic and diagnostic significance of the neutrophil-to-lymphocyte ratio in hepatocellular carcinoma: a prospective controlled study

2021 ◽  
Author(s):  
Philip J. Johnson ◽  
Sofi Dhanaraj ◽  
Sarah Berhane ◽  
Laura Bonnett ◽  
Yuk Ting Ma
Keyword(s):  
Hepatocellular Carcinoma ◽  
Regression Analysis ◽  
Prognostic Factor ◽  
Cox Regression ◽  
Prognostic Models ◽  
Controlled Study ◽  
Cox Regression Analysis ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Significant Difference

Abstract Background The neutrophil–lymphocyte ratio (NLR), a presumed measure of the balance between neutrophil-associated pro-tumour inflammation and lymphocyte-dependent antitumour immune function, has been suggested as a prognostic factor for several cancers, including hepatocellular carcinoma (HCC). Methods In this study, a prospectively accrued cohort of 781 patients (493 HCC and 288 chronic liver disease (CLD) without HCC) were followed-up for more than 6 years. NLR levels between HCC and CLD patients were compared, and the effect of baseline NLR on overall survival amongst HCC patients was assessed via multivariable Cox regression analysis. Results On entry into the study (‘baseline’), there was no clinically significant difference in the NLR values between CLD and HCC patients. Amongst HCC patients, NLR levels closest to last visit/death were significantly higher compared to baseline. Multivariable Cox regression analysis showed that NLR was an independent prognostic factor, even after adjustment for the HCC stage. Conclusion NLR is a significant independent factor influencing survival in HCC patients, hence offering an additional dimension in prognostic models.

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