Metformin attenuates H2O2‑induced osteoblast apoptosis by regulating SIRT3 via the PI3K/AKT pathway

Keda Yang; Lei Pei; Siming Zhou; Lin Tao; Yue Zhu

doi:10.3892/etm.2021.10751

Metformin attenuates H2O2‑induced osteoblast apoptosis by regulating SIRT3 via the PI3K/AKT pathway

Experimental and Therapeutic Medicine ◽

10.3892/etm.2021.10751 ◽

2021 ◽

Vol 22 (5) ◽

Author(s):

Keda Yang ◽

Lei Pei ◽

Siming Zhou ◽

Lin Tao ◽

Yue Zhu

Keyword(s):

Akt Pathway ◽

Osteoblast Apoptosis

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Allicin inhibits osteoblast apoptosis and steroid-induced necrosis of femoral head progression by activating the PI3K/AKT pathway

Food & Function ◽

10.1039/d0fo00837k ◽

2020 ◽

Vol 11 (9) ◽

pp. 7830-7841 ◽

Cited By ~ 2

Author(s):

Jingdi Zhan ◽

Zijian Yan ◽

Mengyao Zhao ◽

Weihui Qi ◽

Jian Lin ◽

...

Keyword(s):

Femoral Head ◽

Avascular Necrosis ◽

Major Complication ◽

Akt Pathway ◽

Clinical Use ◽

Osteoblast Apoptosis ◽

Necrosis Of Femoral Head

Steroid-induced avascular necrosis of the femoral head (SANFH) is a major complication of long-term or excessive clinical use of glucocorticoids.

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309 Effect of poly(ADP-ribose) polymerase inhibitors on the activation of the protective Akt pathway in Langendorff perfused hearts

European Journal of Heart Failure Supplements ◽

10.1016/s1567-4215(03)90170-6 ◽

2003 ◽

Vol 2 (1) ◽

pp. 55-56

Author(s):

S SUMEGI ◽

K KOVACS ◽

A TOTH ◽

P DERES

Keyword(s):

Akt Pathway ◽

Polymerase Inhibitors ◽

Perfused Hearts

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Decision letter for "Intracellular accumulation of advanced glycation end‐products induces osteoblast apoptosis via endoplasmic reticulum stress"

10.1002/jbmr.4053/v1/decision1 ◽

2020 ◽

Keyword(s):

Endoplasmic Reticulum ◽

Endoplasmic Reticulum Stress ◽

Advanced Glycation End Products ◽

Intracellular Accumulation ◽

Advanced Glycation ◽

Glycation End Products ◽

End Products ◽

Osteoblast Apoptosis

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The phosphatidylinositol-3 kinase/Akt pathway mediates VEGF's neuroprotective activity and induces blood brain barrier permeability after focal cerebral ischaemia

Aktuelle Neurologie ◽

10.1055/s-2006-953265 ◽

2006 ◽

Vol 33 (S 1) ◽

Author(s):

E. Kilic ◽

U. Kilic ◽

Y. Wang ◽

C.L. Bassetti ◽

H.H. Marti ◽

...

Keyword(s):

Blood Brain Barrier ◽

Cerebral Ischaemia ◽

Brain Barrier ◽

Neuroprotective Activity ◽

Akt Pathway ◽

Focal Cerebral Ischaemia ◽

Phosphatidylinositol 3 Kinase ◽

Barrier Permeability ◽

Blood Brain Barrier Permeability ◽

Brain Barrier Permeability

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Evaluation of the improvement in vascular endothelial function from raphanus sativus via activation of PI3K/Akt pathway

Endocrine Abstracts ◽

10.1530/endoabs.63.p566 ◽

2019 ◽

Author(s):

Kyung-A Hwang ◽

Hye-Jeong Hwang ◽

Sung-Hyeon Lee ◽

Hwan-Hee Jang

Keyword(s):

Endothelial Function ◽

Raphanus Sativus ◽

Akt Pathway ◽

Vascular Endothelial ◽

Vascular Endothelial Function

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Fenhexamid increased the cell viability and metastasis of breast cancer cells via an estrogen receptor-dependent and PI3K/AKT pathway

Endocrine Abstracts ◽

10.1530/endoabs.63.p331 ◽

2019 ◽

Author(s):

Ryeo-Eun Go ◽

Kyung-A Hwang ◽

Kyung-Chul Choi

Keyword(s):

Breast Cancer ◽

Estrogen Receptor ◽

Cell Viability ◽

Cancer Cells ◽

Breast Cancer Cells ◽

Akt Pathway

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Faculty Opinions recommendation of Reduction in the requirement of oncogenic Ras signaling to activation of PI3K/AKT pathway during tumor maintenance.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1029136.346434 ◽

2005 ◽

Author(s):

Dafna Bar-Sagi

Keyword(s):

Akt Pathway ◽

Ras Signaling ◽

Oncogenic Ras ◽

Tumor Maintenance

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Faculty Opinions recommendation of The Akt-specific inhibitor MK2206 selectively inhibits thyroid cancer cells harboring mutations that can activate the PI3K/Akt pathway.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.10786957.11690056 ◽

2011 ◽

Author(s):

Gilbert Cote

Keyword(s):

Thyroid Cancer ◽

Cancer Cells ◽

Specific Inhibitor ◽

Akt Pathway ◽

Thyroid Cancer Cells

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Faculty Opinions recommendation of MicroRNA-7 inhibits tumor growth and metastasis by targeting the phosphoinositide 3-kinase/Akt pathway in hepatocellular carcinoma.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.717647954.793152961 ◽

2012 ◽

Author(s):

Grace Guo ◽

Guodong Li

Keyword(s):

Hepatocellular Carcinoma ◽

Tumor Growth ◽

Akt Pathway ◽

Tumor Growth And Metastasis ◽

Phosphoinositide 3 Kinase

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Faculty Opinions recommendation of Cullin7 enhances resistance to trastuzumab therapy in Her2 positive breast cancer via degrading IRS-1 and downregulating IGFBP-3 to activate the PI3K/AKT pathway.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.736510387.793572327 ◽

2020 ◽

Author(s):

Steven A Rosenzweig

Keyword(s):

Breast Cancer ◽

Akt Pathway ◽

Her2 Positive ◽

Her2 Positive Breast Cancer ◽

Trastuzumab Therapy ◽

Igfbp 3 ◽

Positive Breast Cancer

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