scholarly journals The anti‑inflammation effect of strontium ranelate on rat chondrocytes with or without IL‑1β in vitro

2022 ◽  
Vol 23 (3) ◽  
Author(s):  
Hao Yu ◽  
Yan Liu ◽  
Xiangwen Yang ◽  
Jiajing He ◽  
Qun Zhong ◽  
...  
Keyword(s):  
Strontium Ranelate ◽  
Anti Inflammation

Methylmercury-induced pro-inflammatory cytokines activation and its preventive strategy using anti-inflammation N-acetyl-l-cysteine: a mini-review

2020 ◽  
Vol 35 (3) ◽  
pp. 233-238
Author(s):  
Muflihatul Muniroh
Keyword(s):  
Inflammatory Cytokines ◽  
Health Concern ◽  
Brain Cells ◽  
Preventive Strategy ◽  
Hearing Impairments ◽  
Sensory Disturbances ◽  
Anti Inflammation ◽  
Pro Inflammatory Cytokines

AbstractThe exposure of methylmercury (MeHg) has become a public health concern because of its neurotoxic effect. Various neurological symptoms were detected in Minamata disease patients, who got intoxicated by MeHg, including paresthesia, ataxia, gait disturbance, sensory disturbances, tremors, visual, and hearing impairments, indicating that MeHg could pass the blood-brain barrier (BBB) and cause impairment of neurons and other brain cells. Previous studies have reported some expected mechanisms of MeHg-induced neurotoxicity including the neuroinflammation pathway. It was characterized by the up-regulation of numerous pro-inflammatory cytokines expression. Therefore, the use of anti-inflammatories such as N-acetyl-l-cysteine (NAC) may act as a preventive compound to protect the brain from MeHg harmful effects. This mini-review will explain detailed information on MeHg-induced pro-inflammatory cytokines activation as well as possible preventive strategies using anti-inflammation NAC to protect brain cells, particularly in in vivo and in vitro studies.

GR-mediated anti-inflammation of α-boswellic acid: Insights from in vitro and in silico studies

2021 ◽  
Vol 155 ◽  
pp. 112379
Author(s):  
Jie Zhang ◽  
Jiarui Zhao ◽  
Yantong Sun ◽  
Yuan Liang ◽  
Jingqi Zhao ◽  
...  
Keyword(s):  
In Silico ◽  
Boswellic Acid ◽  
In Silico Studies ◽  
Anti Inflammation

Homoisoflavonoid derivatives from the roots of Ophiopogon japonicus and their in vitro anti-inflammation activity

2010 ◽  
Vol 20 (8) ◽  
pp. 2412-2416 ◽  
Author(s):  
Tran Manh Hung ◽  
Cao Van Thu ◽  
Nguyen Tien Dat ◽  
Sung-Woo Ryoo ◽  
Jeong Hyung Lee ◽  
...  
Keyword(s):  
Ophiopogon Japonicus ◽  
Anti Inflammation

scholarly journals The effect of strontium ranelate on titanium particle-induced periprosthetic osteolysis regulated by WNT/β-catenin signaling in vivo and in vitro

2021 ◽  
Vol 41 (1) ◽  
Author(s):  
Bolun Wang ◽  
Haohui Guo ◽  
Tianxiang Geng ◽  
Kening Sun ◽  
Liang Zhang ◽  
...  
Keyword(s):  
Bone Resorption ◽  
Aseptic Loosening ◽  
Cell Line ◽  
Conditioned Medium ◽  
Strontium Ranelate ◽  
Cell Model ◽  
Periprosthetic Osteolysis ◽  
A Cell

Abstract Aseptic loosening following periprosthetic osteolysis is the primary complication that limits the lifetime of total joint arthroplasty (TJA). The wear particles trigger a chronic inflammation response in the periprosthetic tissue and turn over the bone balance to bone resorption. The present study aimed to investigate the possible effect and mechanism of strontium ranelate (SR), a clinically safe drug for osteoporosis, on particle-induced periprosthetic osteolysis. Thirty-six female C57BL/6j mice underwent tibial Ti-nail implantation to establish an animal model of aseptic loosening. After 12 weeks, micro-CT results showed that strontium ranelate could inhibit periprosthetic bone resorption. In vitro, Ti particles were used to stimulate RAW264.7 cell line to collect conditioned medium, and co-culture MC3T3-E1 cell line with conditioned medium to establish a cell model of aseptic loosening. The results of alkaline phosphatase (ALP) detection, immunofluorescence, and flow cytometry demonstrated that strontium ranelate could regulate the expression of OPG/RANKL, promote differentiation and mineralization, and inhibit apoptosis in osteoblasts. Moreover, we revealed that SR’s exerted its therapeutic effect by down-regulating sclerostin, thereby activating the Wnt/β-catenin signal pathway. Therefore, this research suggests that strontium ranelate could be a potential drug for the prevention and treatment of particle-induced aseptic loosening post-TJA.

Nanostrontium ranelate incorporated injectable hydrogel enhanced matrix production supporting chondrogenesis in vitro

2016 ◽  
Vol 4 (23) ◽  
pp. 4092-4103 ◽  
Author(s):  
S. Deepthi ◽  
Amna A. Abdul Gafoor ◽  
A. Sivashanmugam ◽  
Shantikumar V. Nair ◽  
R. Jayakumar
Keyword(s):  
Controlled Release ◽  
Strontium Ranelate ◽  
Injectable Hydrogel ◽  
Composite Gel ◽  
Matrix Production

An injectable strontium ranelate nanoparticle-loaded composite gel provides a required environment for chondrogenesis, supplemented with the controlled release of strontium ranelate.

scholarly journals Research Advances of Purple Sweet Potato Anthocyanins: Extraction, Identification, Stability, Bioactivity, Application, and Biotransformation

Molecules ◽  
2019 ◽  
Vol 24 (21) ◽  
pp. 3816 ◽  
Author(s):  
Aoran Li ◽  
Ruoshi Xiao ◽  
Sijia He ◽  
Xiaoyu An ◽  
Yi He ◽  
...  
Keyword(s):  
Sweet Potato ◽  
Structural Characterization ◽  
Functional Activity ◽  
Red Pigments ◽  
Comprehensive Review ◽  
Development And Utilization ◽  
Purple Sweet Potato ◽  
Further Development ◽  
Anti Inflammation

Purple sweet potato anthocyanins are kinds of natural anthocyanin red pigments extracted from the root or stem of purple sweet potato. They are stable and have the functions of anti-oxidation, anti-mutation, anti-tumor, liver protection, hypoglycemia, and anti-inflammation, which confer them a good application prospect. Nevertheless, there is not a comprehensive review of purple sweet potato anthocyanins so far. The extraction, structural characterization, stability, functional activity, application in the food, cosmetics, medicine, and other industries of anthocyanins from purple sweet potato, together with their biotransformation in vitro or by gut microorganism are reviewed in this paper, which provides a reference for further development and utilization of anthocyanins.

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