Dihydropyrimidine dehydrogenase, multidrug resistance-associated protein, and thymidylate synthase gene expression levels can predict 5-fluorouracil resistance in human gastrointestinal cancer cells.

1999 ◽  
Author(s):  
Y Kirihara ◽  
W Yamamoto ◽  
T Toge ◽  
M Nishiyama
Keyword(s):  
Gene Expression ◽  
Multidrug Resistance ◽  
Cancer Cells ◽  
Thymidylate Synthase ◽  
Gastrointestinal Cancer ◽  
Dihydropyrimidine Dehydrogenase ◽  
Expression Levels ◽  
Gene Expression Levels

Colorectal Carcinomas with Microsatellite Instability Display Increased Thymidylate Synthase Gene Expression Levels

2007 ◽  
Vol 6 (10) ◽  
pp. 720-727 ◽  
Author(s):  
Elisabeth Odin ◽  
Yvonne Wettergren ◽  
Staffan Nilsson ◽  
Göran Carlsson ◽  
Bengt Gustavsson
Keyword(s):  
Gene Expression ◽  
Microsatellite Instability ◽  
Thymidylate Synthase ◽  
Colorectal Carcinomas ◽  
Expression Levels ◽  
Gene Expression Levels

Discrimination and evaluation of lactoferrin and delta-lactoferrin gene expression levels in cancer cells and under inflammatory stimuli using TaqMan real-time PCR

BioMetals ◽  
2010 ◽  
Vol 23 (3) ◽  
pp. 441-452 ◽  
Author(s):  
Esthelle Hoedt ◽  
Stephan Hardivillé ◽  
Christophe Mariller ◽  
E. Elass ◽  
Jean-Paul Perraudin ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cancer Cells ◽  
Real Time ◽  
Real Time Pcr ◽  
Expression Levels ◽  
Inflammatory Stimuli ◽  
Lactoferrin Gene ◽  
Gene Expression Levels

scholarly journals Effect of magnevist conjugated dendrimer on Bax/Bcl2 gene expression levels in MCF-7 cancer cells

2016 ◽  
Vol 4 (4) ◽  
pp. 440-447 ◽  
Author(s):  
Sara Fattah ◽  
◽  
Bahar Javani ◽  
Mostafa Saffari ◽  
SeyedAtaollah Sadat Shandiz ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cancer Cells ◽  
Expression Levels ◽  
Bcl2 Gene ◽  
Gene Expression Levels ◽  
Mcf 7

Human Multidrug Resistance-1 Gene Expression Levels in Graves-Basedow Disease

2010 ◽  
Vol 118 (03) ◽  
pp. 158-160 ◽  
Author(s):  
Ş. Çetinkalp ◽  
M. Karadeniz ◽  
M. Erdoğan ◽  
Z. Eroğlu ◽  
A. Zengi ◽  
...  
Keyword(s):  
Gene Expression ◽  
Multidrug Resistance ◽  
Expression Levels ◽  
Multidrug Resistance 1 Gene ◽  
Gene Expression Levels

scholarly journals A Sparse and Low-Rank Regression Model for Identifying the Relationships Between DNA Methylation and Gene Expression Levels in Gastric Cancer and the Prediction of Prognosis

Genes ◽  
2021 ◽  
Vol 12 (6) ◽  
pp. 854
Author(s):  
Yishu Wang ◽  
Lingyun Xu ◽  
Dongmei Ai
Keyword(s):  
Gene Expression ◽  
Gastric Cancer ◽  
Dna Methylation ◽  
Regression Model ◽  
The Cancer Genome Atlas ◽  
Low Rank ◽  
Expression Levels ◽  
Rank Regression ◽  
Prediction Of Prognosis ◽  
Gene Expression Levels

DNA methylation is an important regulator of gene expression that can influence tumor heterogeneity and shows weak and varying expression levels among different genes. Gastric cancer (GC) is a highly heterogeneous cancer of the digestive system with a high mortality rate worldwide. The heterogeneous subtypes of GC lead to different prognoses. In this study, we explored the relationships between DNA methylation and gene expression levels by introducing a sparse low-rank regression model based on a GC dataset with 375 tumor samples and 32 normal samples from The Cancer Genome Atlas database. Differences in the DNA methylation levels and sites were found to be associated with differences in the expressed genes related to GC development. Overall, 29 methylation-driven genes were found to be related to the GC subtypes, and in the prognostic model, we explored five prognoses related to the methylation sites. Finally, based on a low-rank matrix, seven subgroups were identified with different methylation statuses. These specific classifications based on DNA methylation levels may help to account for heterogeneity and aid in personalized treatments.

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