Genome-wide analysis of gene-expression profiles in chronic myeloid leukemia cells using a cDNA microarray

2003 ◽  
Author(s):  
Yasuyuki Kaneta ◽  
Yoshitoyo Kagami ◽  
Tatsuhiko Tsunoda ◽  
Ryuzo Ohno ◽  
Yusuke Nakamura ◽  
...  
Keyword(s):  
Gene Expression ◽  
Chronic Myeloid Leukemia ◽  
Cdna Microarray ◽  
Myeloid Leukemia ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Leukemia Cells ◽  
Genome Wide Analysis ◽  
Genome Wide

scholarly journals Genome-wide analysis of developmental and sex-regulated gene expression profiles in Caenorhabditis elegans

2001 ◽  
Vol 98 (1) ◽  
pp. 218-223 ◽  
Author(s):  
M. Jiang ◽  
J. Ryu ◽  
M. Kiraly ◽  
K. Duke ◽  
V. Reinke ◽  
...  
Keyword(s):  
Gene Expression ◽  
Caenorhabditis Elegans ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Genome Wide Analysis ◽  
Genome Wide ◽  
Regulated Gene Expression

Diagnosing and Managing Advanced Chronic Myeloid Leukemia

2015 ◽  
pp. e381-e388 ◽  
Author(s):  
Michael W. Deininger
Keyword(s):  
Gene Expression ◽  
Chronic Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Kinase Inhibitor ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Chronic Phase ◽  
Clinical Staging ◽  
Molecular Monitoring ◽  
Hematopoietic Stem

Clinical staging of chronic myeloid leukemia (CML) distinguishes between chronic phase (CP-CML), accelerated phase (AP-CML), and blastic phase (BP-CML), reflecting its natural history in the absence of effective therapy. Morphologically, transformation from CP-CML to AP/BP-CML is characterized by a progressive or sudden loss of differentiation. Multiple different somatic mutations have been implicated in transformation from CP-CML to AP/BC-CML, but no characteristic mutation or combination of mutations have emerged. Gene expression profiles of AP-CML and BP-CML are similar, consistent with biphasic evolution at the molecular level. Gene expression of tyrosine kinase inhibitor (TKI)–resistant CP-CML and second CP-CML resemble AP/BP-CML, suggesting that morphology alone is a poor predictor of biologic behavior. At the clinical level, progression to AP/BP-CML or resistance to first-line TKI therapy distinguishes a good risk condition with survival close to the general population from a disease likely to reduce survival. Progression while receiving TKI therapy is frequently caused by mutations in the target kinase BCR-ABL1, but progression may occur in the absence of explanatory BCR-ABL1 mutations, suggesting involvement of alternative pathways. Identifying patients in whom milestones of TKI response fail to occur or whose disease progress while receiving therapy requires appropriate molecular monitoring. Selection of salvage TKI depends on prior TKI history, comorbidities, and BCR-ABL1 mutation status. Despite the introduction of novel TKIs, therapy of AP/BP-CML remains challenging and requires accepting modalities with substantial toxicity, such as hematopoietic stem cell transplantation (HSCT).

Genome-wide analysis of gene expression profiles during ear development of maize

2009 ◽  
Vol 70 (1-2) ◽  
pp. 63-77 ◽  
Author(s):  
Yun Zhu ◽  
Junjie Fu ◽  
Jinpeng Zhang ◽  
Tingsong Liu ◽  
Zhiwei Jia ◽  
...  
Keyword(s):  
Gene Expression ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Ear Development ◽  
Genome Wide Analysis ◽  
Genome Wide

scholarly journals Global gene expression profiles of hematopoietic stem and progenitor cells from patients with chronic myeloid leukemia: the effect of in vitro culture with or without imatinib

2017 ◽  
Vol 6 (12) ◽  
pp. 2942-2956 ◽  
Author(s):  
Sócrates Avilés-Vázquez ◽  
Antonieta Chávez-González ◽  
Alfredo Hidalgo-Miranda ◽  
Dafne Moreno-Lorenzana ◽  
Lourdes Arriaga-Pizano ◽  
...  
Keyword(s):  
Gene Expression ◽  
Chronic Myeloid Leukemia ◽  
Progenitor Cells ◽  
Myeloid Leukemia ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Global Gene Expression ◽  
Hematopoietic Stem ◽  
Stem And Progenitor Cells

Genome-wide analysis of microRNA and gene expression profiles in human lymphocytes cultured in modeled microgravity during the DNA-damage response to γ-rays

2014 ◽  
Vol 25 (S1) ◽  
pp. 53-57
Author(s):  
Cristina Girardi ◽  
Cristiano De Pittà ◽  
Silvia Casara ◽  
Gabriele Sales ◽  
Gerolamo Lanfranchi ◽  
...  
Keyword(s):  
Gene Expression ◽  
Dna Damage ◽  
Dna Damage Response ◽  
Expression Profiles ◽  
Human Lymphocytes ◽  
Gene Expression Profiles ◽  
Genome Wide Analysis ◽  
Genome Wide ◽  
Damage Response ◽  
Γ Rays

scholarly journals Genome-Wide Analysis of Gene Expression Profiles Associated with Cell Cycle Transitions in Growing Organs of Arabidopsis

2005 ◽  
Vol 138 (2) ◽  
pp. 734-743 ◽  
Author(s):  
Gerrit T.S. Beemster ◽  
Lieven De Veylder ◽  
Steven Vercruysse ◽  
Gerrit West ◽  
Debbie Rombaut ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cell Cycle ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Genome Wide Analysis ◽  
Genome Wide
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