HEPATOCYTE GROWTH-FACTOR AND ITS RECEPTOR C-MET REGULATE BOTH CELL-GROWTH AND INVASION OF HUMAN PANCREATIC-CANCER

1995 ◽  
Author(s):  
Y HASEGAWA ◽  
M YAMAMOTO ◽  
S MAEDA ◽  
Y SAITOH
Keyword(s):  
Pancreatic Cancer ◽  
Growth Factor ◽  
Cell Growth ◽  
Hepatocyte Growth Factor ◽  
Human Pancreatic Cancer ◽  
Hepatocyte Growth

Hepatocyte Growth Factor and Macrophage-stimulating Protein “Hinge” Analogs to Treat Pancreatic Cancer

2019 ◽  
Vol 19 (10) ◽  
pp. 782-795
Author(s):  
John W. Wright ◽  
Kevin J. Church ◽  
Joseph W. Harding
Keyword(s):  
Pancreatic Cancer ◽  
Signal Transduction ◽  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Tumor Growth ◽  
Receptor Activation ◽  
Signal Transduction Pathways ◽  
Met Receptor ◽  
Macrophage Stimulating Protein ◽  
Hepatocyte Growth

Pancreatic cancer (PC) ranks twelfth in frequency of diagnosis but is the fourth leading cause of cancer related deaths with a 5 year survival rate of less than 7 percent. This poor prognosis occurs because the early stages of PC are often asymptomatic. Over-expression of several growth factors, most notably vascular endothelial growth factor (VEGF), has been implicated in PC resulting in dysfunctional signal transduction pathways and the facilitation of tumor growth, invasion and metastasis. Hepatocyte growth factor (HGF) acts via the Met receptor and has also received research attention with ongoing efforts to develop treatments to block the Met receptor and its signal transduction pathways. Macrophage-stimulating protein (MSP), and its receptor Ron, is also recognized as important in the etiology of PC but is less well studied. Although the angiotensin II (AngII)/AT1 receptor system is best known for mediating blood pressure and body water/electrolyte balance, it also facilitates tumor vascularization and growth by stimulating the expression of VEGF. A metabolite of AngII, angiotensin IV (AngIV) has sequence homology with the “hinge regions” of HGF and MSP, key structures in the growth factor dimerization processes necessary for Met and Ron receptor activation. We have developed AngIV-based analogs designed to block dimerization of HGF and MSP and thus receptor activation. Norleual has shown promise as tested utilizing PC cell cultures. Results indicate that cell migration, invasion, and pro-survival functions were suppressed by this analog and tumor growth was significantly inhibited in an orthotopic PC mouse model.

NEUROPILIN-1 ASSOCIATION WITH c-MET IN PANCREATIC CANCER CELLS ENHANCES HEPATOCYTE GROWTH FACTOR-MEDIATED CELL INVASION

Pancreas ◽  
2007 ◽  
Vol 35 (4) ◽  
pp. 415
Author(s):  
A. Matsushita ◽  
T. Götze ◽  
M. Kawamoto ◽  
K. Cho ◽  
Y. Nakamura ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Cancer Cells ◽  
Cell Invasion ◽  
Pancreatic Cancer Cells ◽  
Neuropilin 1 ◽  
Hepatocyte Growth

scholarly journals Analogs of the hepatocyte growth factor and macrophage-stimulating protein hinge regions act as Met and Ron dual inhibitors in pancreatic cancer cells

2016 ◽  
Vol 27 (8) ◽  
pp. 766-779 ◽  
Author(s):  
Kevin J. Church ◽  
Brett R. Vanderwerff ◽  
Rachelle R. Riggers ◽  
Michelle D. McMicheal ◽  
Beatriz Mateo-Victoriano ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Cancer Cells ◽  
Macrophage Stimulating Protein ◽  
Pancreatic Cancer Cells ◽  
Dual Inhibitors ◽  
Hepatocyte Growth

The antifibrogenic effect of hepatocyte growth factor (HGF) on renal tubular (HK-2) cells is dependent on cell growth

2009 ◽  
Vol 27 (3) ◽  
pp. 173-180 ◽  
Author(s):  
Ciro Esposito ◽  
Bina Parrilla ◽  
Flavia Cornacchia ◽  
Fabrizio Grosjean ◽  
Filippo Mangione ◽  
...  
Keyword(s):  
Growth Factor ◽  
Cell Growth ◽  
Hepatocyte Growth Factor ◽  
Antifibrogenic Effect ◽  
Renal Tubular ◽  
Hepatocyte Growth
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