scholarly journals Suppression of microRNA-18a expression inhibits invasion and promotes apoptosis of human trophoblast cells by targeting the estrogen receptor α gene

2015 ◽  
Vol 12 (2) ◽  
pp. 2701-2706 ◽  
Author(s):  
XIAOMING ZHU ◽  
YANG YANG ◽  
TAO HAN ◽  
GUOWU YIN ◽  
PING GAO ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Estrogen Receptor Α ◽  
Trophoblast Cells ◽  
Human Trophoblast ◽  
Estrogen Receptor Α Gene ◽  
Human Trophoblast Cells

scholarly journals G protein-coupled estrogen receptor stimulates human trophoblast cell invasion via YAP-mediated ANGPTL4 expression

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Jung-Chien Cheng ◽  
Lanlan Fang ◽  
Yuxi Li ◽  
Avinash Thakur ◽  
Pamela A. Hoodless ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
G Protein ◽  
Cell Invasion ◽  
Trophoblast Cell ◽  
Estrogen Signaling ◽  
Trophoblast Cells ◽  
Independent Manner ◽  
Human Trophoblast ◽  
G Protein Coupled ◽  
Human Trophoblast Cells

AbstractInsufficient invasion of trophoblast cells into the uterine decidua is associated with preeclampsia (PE). G protein-coupled estrogen receptor (GPER) is a membrane estrogen receptor involved in non-genomic estrogen signaling. GPER is expressed in human trophoblast cells and downregulated GPER levels are noted in PE. However, to date, the role of GPER in trophoblast cells remains largely unknown. Here, we applied RNA sequencing (RNA-seq) to HTR-8/SVneo human trophoblast cells in response to G1, an agonist of GPER, and identified angiopoietin-like 4 (ANGPTL4) as a target gene of GPER. Treatment of trophoblast cells with G1 or 17β-estradiol (E2) activated Yes-associated protein (YAP), the major downstream effector of the Hippo pathway, via GPER but in a mammalian STE20-like protein kinase 1 (MST1)-independent manner. Using pharmacological inhibitors as well as loss- and gain-of-function approaches, our results revealed that YAP activation was required for GPER-stimulated ANGPTL4 expression. Transwell invasion assays demonstrated that activation of GPER-induced ANGPTL4 promoted cell invasion. In addition, the expression levels of GPER, YAP, and ANGPTL4 were downregulated in the placenta of patients with PE. Our findings reveal a mechanism by which GPER exerts its stimulatory effect on human trophoblast cell invasion by upregulating YAP-mediated ANGPTL4 expression.

596: Determinants of invasion in human trophoblast cells

2007 ◽  
Vol 197 (6) ◽  
pp. S172
Author(s):  
Kathryn Drennan ◽  
Adrian Platts ◽  
Amelia Linneman ◽  
Graham Johnson ◽  
Stephen Krawetz
Keyword(s):  
Trophoblast Cells ◽  
Human Trophoblast ◽  
Human Trophoblast Cells

Estrogen Receptor α Gene Polymorphisms and Bone Mineral Density in Healthy Children and Young Adults

2004 ◽  
Vol 74 (6) ◽  
pp. 495-500 ◽  
Author(s):  
A. M. Boot ◽  
I. M. van der Sluis ◽  
S. M. P. F. de Muinck Keizer-Schrama ◽  
J. B. J. van Meurs ◽  
E. P. Krenning ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Estrogen Receptor ◽  
Young Adults ◽  
Bone Mineral ◽  
Gene Polymorphisms ◽  
Estrogen Receptor Α ◽  
Healthy Children ◽  
Mineral Density ◽  
Children And Young Adults ◽  
Estrogen Receptor Α Gene

scholarly journals PPARα agonists clofibrate and gemfibrozil inhibit cell growth, down-regulate hCG and up-regulate progesterone secretions in immortalized human trophoblast cells

2004 ◽  
Vol 68 (2) ◽  
pp. 313-321 ◽  
Author(s):  
Fumie Hashimoto ◽  
Yoshinobu Oguchi ◽  
Mieko Morita ◽  
Kikumi Matsuoka ◽  
Satoru Takeda ◽  
...  
Keyword(s):  
Cell Growth ◽  
Trophoblast Cells ◽  
Human Trophoblast ◽  
Inhibit Cell Growth ◽  
Human Trophoblast Cells

Association between estrogen receptor-α gene polymorphisms and dermatomyositis in Bulgarian patients

2014 ◽  
Vol 53 (7) ◽  
pp. e363-e364 ◽  
Author(s):  
Lyubomir Dourmishev ◽  
Zornitsa Kamenarska ◽  
Radka Kaneva ◽  
Vanio Mitev ◽  
Maria Hristova ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Gene Polymorphisms ◽  
Estrogen Receptor Α ◽  
Estrogen Receptor Α Gene

scholarly journals Preliminary genetic imaging study of the association between estrogen receptor-α gene polymorphisms and harsh human maternal parenting

2012 ◽  
Vol 525 (1) ◽  
pp. 17-22 ◽  
Author(s):  
Benjamin B. Lahey ◽  
Kalina J. Michalska ◽  
Chunyu Liu ◽  
Qi Chen ◽  
Alison E. Hipwell ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Gene Polymorphisms ◽  
Imaging Study ◽  
Estrogen Receptor Α ◽  
Maternal Parenting ◽  
Estrogen Receptor Α Gene ◽  
Genetic Imaging

Syncytin-2 Plays an Important Role in the Fusion of Human Trophoblast Cells

2009 ◽  
Vol 392 (2) ◽  
pp. 301-318 ◽  
Author(s):  
Amandine Vargas ◽  
Julie Moreau ◽  
Sébastien Landry ◽  
Frédérique LeBellego ◽  
Chirine Toufaily ◽  
...  
Keyword(s):  
Trophoblast Cells ◽  
Human Trophoblast ◽  
Human Trophoblast Cells
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