Radiosensitization of a human soft tissue sarcoma cell line US8-93 (mt-p53) with the oxidizer sodium peroxodisulfate

2004 ◽  
Author(s):  
Matthias Bache ◽  
Jürgen Dunst ◽  
Frank Matschiner ◽  
Sybille Matschiner ◽  
Matthias Kappler ◽  
...  
1995 ◽  
Vol 97 (3) ◽  
pp. 287-296 ◽  
Author(s):  
Martin R. Osborne ◽  
Philip D. Lawley ◽  
Christopher Crofton-Sleigh ◽  
William Warren

2010 ◽  
Vol 48 (2) ◽  
pp. 482-485 ◽  
Author(s):  
S. A. Snyder ◽  
K. Linder ◽  
B. Hedan ◽  
M. L. Hauck

2013 ◽  
Vol 1 (1) ◽  
pp. 61-68 ◽  
Author(s):  
Xiaochun Wang ◽  
David Goldstein ◽  
Philip J. Crowe ◽  
Jia-Lin Yang

2000 ◽  
Vol 27 (12) ◽  
pp. 1839-1843 ◽  
Author(s):  
Margarida Rodrigues ◽  
Fadi Chehne ◽  
Waclawa Kalinowska ◽  
Christoph Zielinski ◽  
Helmut Sinzinger

1993 ◽  
Vol 63 (2) ◽  
pp. 191-198 ◽  
Author(s):  
W.K. Dahlberg ◽  
J.B. Little ◽  
J.A. Fletcher ◽  
H.D. Suit ◽  
P. Okunieff

Author(s):  
Wei-Wei Li ◽  
Carlos Cordon-Cardo ◽  
Quanguang Chen ◽  
Suresh C. Jhanwar ◽  
Joseph R. Bertino

1995 ◽  
Vol 14 (2) ◽  
pp. 263-275 ◽  
Author(s):  
D M Thomas ◽  
S D Rogers ◽  
M W Sleeman ◽  
G M Pasquini ◽  
F R Bringhurst ◽  
...  

ABSTRACT This study characterizes the actions of insulin and parathyroid hormone (PTH) on the glucose transport system in the rat osteogenic sarcoma cell line UMR 106–01, which expresses a number of features of the osteoblast phenotype. Using [1,2-3H]2-deoxyglucose (2-DOG) as a label, UMR 106–01 cells were shown to possess a glucose transport system which was enhanced by insulin. In contrast, PTH influenced glucose transport in a biphasic manner with a stimulatory effect at 1 h and a more potent inhibitory effect at 16 h on basal and insulin-stimulated 2-DOG transport. To explore the mechanism of PTH action, a direct agonist of cAMP-dependent protein kinase (PKA) was tested. 8-Bromo-cAMP had no acute stimulatory effect but inhibited basal and insulin-stimulated 2-DOG transport at 16 h. This result suggested that the prolonged, but not the acute, effect of PTH was mediated by the generation of cAMP. Further studies with the cell line UMR 4–7, a UMR 106–01 clone stably transfected with an inducible mutant inactive regulatory subunit of PKA, confirmed that the inhibitory but not the stimulatory effect of PTH was mediated by the PKA pathway. Northern blot data indicated that the prolonged inhibitory effects of PTH and 8-bromo-cAMP on glucose transport were likely to be mediated in part by reduction in the levels of GLUT1 (HepG2/brain glucose transporter) mRNA.


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