scholarly journals Hypericin as a marker for determination of tissue viability after radiofrequency ablation in a murine liver tumor model

2008 ◽  
Author(s):  
Marie Van de Putte ◽  
Huaijun Wang ◽  
Feng Chen ◽  
Peter De Witte ◽  
Yicheng Ni
Keyword(s):  
Radiofrequency Ablation ◽  
Liver Tumor ◽  
Tumor Model ◽  
Tissue Viability ◽  
Murine Liver

Hypericin as a Marker for Determination of Tissue Viability After Intratumoral Ethanol Injection in a Murine Liver Tumor Model

2008 ◽  
Vol 15 (1) ◽  
pp. 107-113 ◽  
Author(s):  
Marie Van de Putte ◽  
Huaijun Wang ◽  
Feng Chen ◽  
Peter A.M. de Witte ◽  
Yicheng Ni
Keyword(s):  
Liver Tumor ◽  
Tumor Model ◽  
Tissue Viability ◽  
Ethanol Injection ◽  
Murine Liver

scholarly journals Elastin-specific MRI of extracellular matrix-remodelling following hepatic radiofrequency-ablation in a VX2 liver tumor model

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Federico Collettini ◽  
Carolin Reimann ◽  
Julia Brangsch ◽  
Julius Chapiro ◽  
Lynn Jeanette Savic ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Radiofrequency Ablation ◽  
Mr Imaging ◽  
Liver Tumor ◽  
Tumor Model ◽  
Elastic Fibers ◽  
Specific Probe ◽  
Left Liver Lobe ◽  
Ecm Remodeling ◽  
Icp Ms

AbstractHepatic radiofrequency ablation (RFA) induces a drastic alteration of the biomechanical environment in the peritumoral liver tissue. The resulting increase in matrix stiffness has been shown to significantly influence carcinogenesis and cancer progression after focal RF ablation. To investigate the potential of an elastin-specific MR agent (ESMA) for the assessment of extracellular matrix (ECM) remodeling in the periablational rim following RFA in a VX2 rabbit liver tumor-model, twelve New-Zealand-White-rabbits were implanted in the left liver lobe with VX2 tumor chunks from donor animals. RFA of tumors was performed using a perfused RF needle-applicator with a mean tip temperature of 70 °C. Animals were randomized into four groups for MR imaging and scanned at four different time points following RFA (week 0 [baseline], week 1, week 2 and week 3 after RFA), followed by sacrifice and histopathological analysis. ESMA-enhanced MR imaging was used to assess ECM remodeling. Gadobutrol was used as a third-space control agent. Molecular MR imaging using an elastin-specific probe demonstrated a progressive increase in contrast-to-noise ratio (CNR) (week 3: ESMA: 28.1 ± 6.0; gadobutrol: 3.5 ± 2.0), enabling non-invasive imaging of the peritumoral zone with high spatial-resolution, and accurate assessment of elastin deposition in the periablational rim. In vivo CNR correlated with ex vivo histomorphometry (ElasticaVanGiesson-stain, y = 1.2x − 1.8, R2 = 0.89, p < 0.05) and gadolinium concentrations at inductively coupled mass spectroscopy (ICP-MS, y = 0.04x + 1.2, R2 = 0.95, p < 0.05). Laser-ICP-MS confirmed colocalization of elastin-specific probe with elastic fibers. Following thermal ablation, molecular imaging using an elastin-specific MR probe is feasible and provides a quantifiable biomarker for the assessment of the ablation-induced remodeling of the ECM in the periablational rim.

Design of a Novel Electrode of Radiofrequency Ablation for Large Tumors: In Vitro Validation and Evaluation

2019 ◽  
Vol 141 (3) ◽  
Author(s):  
Zheng Fang ◽  
Micheal A. J. Moser ◽  
Edwin Zhang ◽  
Wenjun Zhang ◽  
Bing Zhang
Keyword(s):  
Computer Simulation ◽  
Radiofrequency Ablation ◽  
Liver Tumor ◽  
Tumor Model ◽  
Egg White ◽  
Large Tumor ◽  
Ablation Volume ◽  
Conventional Electrode

In a prior study, we proposed a novel monopolar expandable electrode (MEE) for use in radiofrequency ablation (RFA). The purpose of our work was to now validate and evaluate this electrode using on in vitro experimental model and computer simulation. Two commercially available RF electrodes (conventional electrode (CE) and umbrella electrode (UE)) were used to compare the ablation results with the novel MEE using an in vitro egg white model and in vivo liver tumor model to verify the efficacy of MEE in the large tumor ablation, respectively. The sharp increase in impedance during RFA procedures was taken as the termination of RFA protocols. In the in vitro egg white experiment, the ablation volume of MEE, CE, and UE was 75.3 ± 1.6 cm3, 2.7 ± 0.4 cm3, and 12.4±1.8 cm3 (P < 0.001), respectively. Correspondingly, the sphericity was 88.1±0.9%, 12.9±1.3%, and 62.0 ± 3.0% (P < 0.001), respectively. A similar result was obtained in the in vitro egg white computer simulation. In the liver tumor computer simulation, the volume and sphericity of ablation zone generated by MEE, CE, and UE were 36.6 cm3 and 93.6%, 3.82 cm3 and 16.9%, and 13.5 cm3 and 56.7%, respectively. In summary, MEE has the potential to achieve complete ablation in the treatment of large tumors (>3 cm in diameter) compared to CE and UE due to the larger electrode–tissue interface and more round shape of hooks.

scholarly journals Ultrasonic Cavitation Ameliorates Antitumor Efficacy of Residual Cancer After Incomplete Radiofrequency Ablation in Rabbit VX2 Liver Tumor Model

2019 ◽  
Vol 12 (8) ◽  
pp. 1113-1121 ◽  
Author(s):  
Shi-yan Li ◽  
Pin-tong Huang ◽  
Yong Fang ◽  
Yao Wu ◽  
Ling Zhou ◽  
...  
Keyword(s):  
Radiofrequency Ablation ◽  
Liver Tumor ◽  
Tumor Model ◽  
Ultrasonic Cavitation ◽  
Antitumor Efficacy ◽  
Residual Cancer

Clinical Application of Radiofrequency Ablation for Malignant Liver Tumor during Interruption of Hepatic Blood Flow

2000 ◽  
Vol 18 ◽  
pp. 121-125
Author(s):  
Takashi Shibata ◽  
Takahiro Niinobu ◽  
Masashi Kitada ◽  
Takashi Shimano ◽  
Motohisa Takami ◽  
...  
Keyword(s):  
Blood Flow ◽  
Radiofrequency Ablation ◽  
Clinical Application ◽  
Hepatic Blood Flow ◽  
Liver Tumor ◽  
Malignant Liver Tumor ◽  
Malignant Liver

Treatment of Metastases to the Vertebrae with Radiofrequency Ablation: Determination of Effectiveness by Evaluation of Tumor Necrosis – A Preliminary Result

2009 ◽  
Vol 2 (3) ◽  
pp. 191-194
Author(s):  
A. Gasbarrini ◽  
M. Cappuccio ◽  
H. Li ◽  
R. Donthineni ◽  
L. Boriani ◽  
...  
Keyword(s):  
Radiofrequency Ablation ◽  
Tumor Necrosis
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