Further analysis of the relationship between the epidemiological and hormonal aspects of 6 human neoplasias with special emphasis on the presentation of the topological features of oncogene activation tumor suppressor gene inactivation of individual neoplasias

1997 ◽  
Author(s):  
M Kodama ◽  
M Murakami ◽  
T Kodama
Keyword(s):  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Suppressor Gene ◽  
Gene Inactivation ◽  
Topological Features ◽  
Oncogene Activation ◽  
Tumor Suppressor Gene Inactivation ◽  
The Relationship

NF2 Tumor Suppressor Gene Inactivation in Advanced Papillary Renal Cell Carcinoma

2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Evgeny Yakirevich ◽  
Dean C. Pavlick ◽  
Carmen M. Perrino ◽  
Melissa Stanton ◽  
Shaolei Lu ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Tumor Suppressor ◽  
Cell Carcinoma ◽  
Tumor Suppressor Gene ◽  
Renal Cell ◽  
Papillary Renal Cell Carcinoma ◽  
Suppressor Gene ◽  
Gene Inactivation ◽  
Tumor Suppressor Gene Inactivation

scholarly journals Passenger mutations can accelerate tumor suppressor gene inactivation in cancer evolution

2017 ◽  
Author(s):  
Dominik Wodarz ◽  
Alan C. Newell ◽  
Natalia L. Komarova
Keyword(s):  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Computational Models ◽  
Evolutionary Process ◽  
Suppressor Gene ◽  
Gene Inactivation ◽  
Relative Fitness ◽  
Driver Mutations ◽  
Tumor Suppressor Gene Inactivation ◽  
Passenger Mutations

AbstractCarcinogenesis is an evolutionary process whereby cells accumulate multiple mutations. Besides the “driver mutations” that cause the disease, cells also accumulate a number of other mutations with seemingly no direct role in this evolutionary process. They are called passenger mutations. While it has been argued that passenger mutations render tumors more fragile due to reduced fitness, the role of passenger mutations remains understudied. Using evolutionary computational models, we demonstrate that in the context of tumor suppressor gene inactivation (and hence fitness valley crossing), the presence of passenger mutations can accelerate the rate of evolution by reducing overall population fitness and increasing the relative fitness of intermediate mutants in the fitness valley crossing pathway. Hence, the baseline rate of tumor suppressor gene inactivation might be faster than previously thought. Conceptually, parallels are found in the field of turbulence and pattern formation, where instabilities can be driven by perturbations that are damped (disadvantageous), but provide a richer set of pathways such that a system can achieve some desired goal more readily. This highlights, through a number of novel parallels, the relevance of physical sciences in oncology.

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