scholarly journals A new model of tumor susceptibility following tumor suppressor gene inactivation

Cell Cycle ◽  
2008 ◽  
Vol 7 (6) ◽  
pp. 735-740 ◽  
Author(s):  
Itsuki Ajioka ◽  
Michael A. Dyer
Keyword(s):  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Suppressor Gene ◽  
Gene Inactivation ◽  
New Model ◽  
Tumor Susceptibility ◽  
Tumor Suppressor Gene Inactivation

NF2 Tumor Suppressor Gene Inactivation in Advanced Papillary Renal Cell Carcinoma

2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Evgeny Yakirevich ◽  
Dean C. Pavlick ◽  
Carmen M. Perrino ◽  
Melissa Stanton ◽  
Shaolei Lu ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Tumor Suppressor ◽  
Cell Carcinoma ◽  
Tumor Suppressor Gene ◽  
Renal Cell ◽  
Papillary Renal Cell Carcinoma ◽  
Suppressor Gene ◽  
Gene Inactivation ◽  
Tumor Suppressor Gene Inactivation

scholarly journals Passenger mutations can accelerate tumor suppressor gene inactivation in cancer evolution

2017 ◽  
Author(s):  
Dominik Wodarz ◽  
Alan C. Newell ◽  
Natalia L. Komarova
Keyword(s):  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Computational Models ◽  
Evolutionary Process ◽  
Suppressor Gene ◽  
Gene Inactivation ◽  
Relative Fitness ◽  
Driver Mutations ◽  
Tumor Suppressor Gene Inactivation ◽  
Passenger Mutations

AbstractCarcinogenesis is an evolutionary process whereby cells accumulate multiple mutations. Besides the “driver mutations” that cause the disease, cells also accumulate a number of other mutations with seemingly no direct role in this evolutionary process. They are called passenger mutations. While it has been argued that passenger mutations render tumors more fragile due to reduced fitness, the role of passenger mutations remains understudied. Using evolutionary computational models, we demonstrate that in the context of tumor suppressor gene inactivation (and hence fitness valley crossing), the presence of passenger mutations can accelerate the rate of evolution by reducing overall population fitness and increasing the relative fitness of intermediate mutants in the fitness valley crossing pathway. Hence, the baseline rate of tumor suppressor gene inactivation might be faster than previously thought. Conceptually, parallels are found in the field of turbulence and pattern formation, where instabilities can be driven by perturbations that are damped (disadvantageous), but provide a richer set of pathways such that a system can achieve some desired goal more readily. This highlights, through a number of novel parallels, the relevance of physical sciences in oncology.

The adaptive immune system is a major driver of selection for tumor suppressor gene inactivation

Science ◽  
2021 ◽  
Vol 373 (6561) ◽  
pp. 1327-1335
Author(s):  
Timothy D. Martin ◽  
Rupesh S. Patel ◽  
Danielle R. Cook ◽  
Mei Yuk Choi ◽  
Ajinkya Patil ◽  
...  
Keyword(s):  
Immune System ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Adaptive Immune System ◽  
Suppressor Gene ◽  
Gene Inactivation ◽  
Adaptive Immune ◽  
Selection For ◽  
Tumor Suppressor Gene Inactivation
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