Methyl-substituted 2-aminothiazole–based cobalt(II) and silver(I) complexes:synthesis, X-ray structures, and biological activities

The resulted complexes produced between Fe (III) and Co (II) with biological molecules like amino acids play an important role in human life. They can be used as bioactive compounds as well as in industries. Fe (III) and Co (II) complexes are synthesized with Alanine amino acid. The complexes were characterized by X-ray diffraction, magnetic suscetivility, elemental analysis (AAS), molar conductance, melting point, infrared and uv-visible spectrophotometry analyses. The elemental analyses were used to determine the chelation ratio, 1:3(metal: ligands) for iron (III) Alanine and 1:2 ratio for cobalt (II) Alanine. The molar conductivity of the complexes show that the complexes are not electrolytic in nature. The x-ray data suggest monoclinic crystal system for all the complexes with the exception of Co-alanine, which is hexagonal. The magnetic susceptivility and electronic spectra suggest the complexes are high spin with octahedral geometry.The complexes show enhance activity in comparable to the amino acid.

Download Full-text

The Variation Effect of Mg-doped NPs Prepared by Sol-Gel Method on its Structural Properties and Biological Activities

Journal of Physics Conference Series ◽

10.1088/1742-6596/2114/1/012004 ◽

2021 ◽

Vol 2114 (1) ◽

pp. 012004

Author(s):

Duha S. Ahmed ◽

Noor Q. Ali ◽

Ali A. Taha

Keyword(s):

Biological Activities ◽

Sol Gel ◽

Spherical Particles ◽

X Ray Diffraction ◽

Gel Method ◽

X Ray ◽

Sol Gel Method ◽

Nio Nps ◽

Dopant Element ◽

Mg Doped

Abstract In this paper, we reported the synthesis of NiO NPs and Mg doped-NiO NPs using the facile sol-gel method. Besides, the influence of the variation of Mg dopant on the structural, morphological and optical properties of the prepared Mg-NiO NPs was studied. The synthesized Mg-NiO NPs nanoparticles were characterized by X-Ray Diffraction Analysis (XRD), Energy Dispersive X-ray Spectroscopy (EDS), Fourier-Transform Infrared Spectroscopy (FTIR), Field-Emission Scanning Electron Microscopy (FE-SEM), and UV-Vis spectrophotometer. The X-ray diffraction confirmed the formation of the cubic structure of Mg doped-NiO NPs after doping with the magnesium. The increase in the crystal size was observed with the increase in the concentration of the Mg dopant element. The FESEM images reveal the formation of nickel oxide through the appearance of spherical clusters, while the hybrids appear as wrinkled surface covered with spherical particles of magnesium. The UV-Vis spectrum showed a shift towards shorter wavelengths with an increase in the concentration of the Mg dopant element due to the quantum confinement effect. The hemolysis activity study showed that NiO NPs had a low hemolysis percentage of 1.47% and increased with increasing concentration. While, increasing of the RBC hemolysis (5.9%) after NiO doped with Mg. The antibacterial activity was studied against S. aureus and P. aeruginosa bacteria, and indicated the highest growth inhibition zones of Mg-doped NiO NPs as compared with NiO NPs against of Staphylococcus aureus and Pseudomonas aeruginosa, respectively.

Download Full-text

Discovery of Stealthin Derivatives and Implication of the Amidotransferase FlsN3 in the Biosynthesis of Nitrogen-Containing Fluostatins

Marine Drugs ◽

10.3390/md17030150 ◽

2019 ◽

Vol 17 (3) ◽

pp. 150 ◽

Cited By ~ 2

Author(s):

Chunshuai Huang ◽

Chunfang Yang ◽

Zhuangjie Fang ◽

Liping Zhang ◽

Wenjun Zhang ◽

...

Keyword(s):

Spectroscopic Data ◽

Bioinformatics Analysis ◽

Biological Activities ◽

Side Chain ◽

X Ray Diffraction ◽

X Ray ◽

Aromatic Polyketides ◽

Plausible Mechanism ◽

Encoding Gene

Diazobenzofluorene-containing atypical angucyclines exhibit promising biological activities. Here we report the inactivation of an amidotransferase-encoding gene flsN3 in Micromonospora rosaria SCSIO N160, a producer of fluostatins. Bioinformatics analysis indicated that FlsN3 was involved in the diazo formation. Chemical investigation of the flsN3-inactivation mutant resulted in the isolation of a variety of angucycline aromatic polyketides, including four racemic aminobenzo[b]fluorenes stealthins D–G (9–12) harboring a stealthin C-like core skeleton with an acetone or butanone-like side chain. Their structures were elucidated on the basis of nuclear magnetic resonance (NMR) spectroscopic data and X-ray diffraction analysis. A plausible mechanism for the formation of stealthins D–G (9–12) was proposed. These results suggested a functional role of FlsN3 in the formation/modification of N–N bond-containing fluostatins.

Download Full-text

ChemInform Abstract: Synthesis, X-Ray Analysis, and Biological Activities of Novel Oxazolidinethiones.

ChemInform ◽

10.1002/chin.201511168 ◽

2015 ◽

Vol 46 (11) ◽

pp. no-no

Author(s):

Nezire Saygili ◽

Meral Oezalp ◽

Leyla Tatar Yildirim

Keyword(s):

Biological Activities ◽

X Ray

Download Full-text

Substituent position effect on the crystal structures of N-phenyl-2-phthalimidoethanesulfonamide derivatives

Acta Crystallographica Section C Structural Chemistry ◽

10.1107/s2053229617017442 ◽

2018 ◽

Vol 74 (1) ◽

pp. 31-36

Author(s):

Resul Sevinçek ◽

Duygu Barut Celepci ◽

Serap Köktaş Koca ◽

Özlem Akgül ◽

Muittin Aygün

Keyword(s):

Hydrogen Bonds ◽

Crystal Packing ◽

Biological Activities ◽

Position Effect ◽

Intermolecular Hydrogen Bond ◽

X Ray ◽

Space Groups ◽

X Ray Crystallography ◽

Hydrogen Bond Interactions ◽

The Impact

In order to determine the impact of different substituents and their positions on intermolecular interactions and ultimately on the crystal packing, unsubstituted N-phenyl-2-phthalimidoethanesulfonamide, C16H14N2O4S, (I), and the N-(4-nitrophenyl)-, C16H13N3O6S, (II), N-(4-methoxyphenyl)-, C16H16N3O6S, (III), and N-(2-ethylphenyl)-, as the monohydrate, C18H18N2O4S·H2O, (IV), derivatives have been characterized by single-crystal X-ray crystallography. Sulfonamides (I) and (II) have triclinic crystal systems, while (III) and (IV) are monoclinic. Although the molecules differ from each other only with respect to small substituents and their positions, they crystallized in different space groups as a result of differing intra- and intermolecular hydrogen-bond interactions. The structures of (I), (II) and (III) are stabilized by intermolecular N—H...O and C—H...O hydrogen bonds, while that of (IV) is stabilized by intermolecular O—H...O and C—H...O hydrogen bonds. All four structures are of interest with respect to their biological activities and have been studied as part of a program to develop anticonvulsant drugs for the treatment of epilepsy.

Download Full-text

Synthesis, Biological Activities, and X-ray Crystal Structural Analysis of 25-Hydroxy-25(or 26)-adamantyl-17-[20(22),23-diynyl]-21-norvitamin D Compounds

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.5b00792 ◽

2015 ◽

Vol 58 (24) ◽

pp. 9510-9521 ◽

Cited By ~ 10

Author(s):

Yusuke Watarai ◽

Michiyasu Ishizawa ◽

Teikichi Ikura ◽

Flavia C. M. Zacconi ◽

Shigeyuki Uno ◽

...

Keyword(s):

Structural Analysis ◽

Biological Activities ◽

X Ray ◽

Crystal Structural

Download Full-text

Synthesis, X-Ray Crystal Structure and Biological Activities of α-Phenoxy-1,2,3-thiadiazoleacetamide.

ChemInform ◽

10.1002/chin.200409110 ◽

2004 ◽

Vol 35 (9) ◽

Author(s):

Wei Guang Zhao ◽

Zheng Ming Li ◽

Zhao Yang

Keyword(s):

Crystal Structure ◽

Biological Activities ◽

X Ray

Download Full-text

New Cu(II), Co(II), and Ni(II) complexes with thieno[2,3-b]pyridine and 2-methylthieno[2,3-b]pyridine as ligands: Synthesis and crystal structures

Chemical Papers ◽

10.2478/s11696-009-0015-9 ◽

2009 ◽

Vol 63 (3) ◽

Cited By ~ 1

Author(s):

Ján Halgaš ◽

Viera Kolenová ◽

Zuzana Števíková ◽

Lucia Perašínová ◽

Jozef Kožíšek

Keyword(s):

Single Crystal ◽

Diffraction Analysis ◽

Crystal Structures ◽

Elemental Analysis ◽

Zinc Chloride ◽

Coordination Compounds ◽

Biological Activities ◽

X Ray Diffraction ◽

X Ray ◽

Ft Ir

AbstractAlthough thienopyridines attract attention because of their biological activities, they have not been used as ligands in coordination compounds. Thieno[2,3-b]pyridine was prepared by known procedures; by reduction of 2-nitrothiophene, and reaction of the resulting 2-thienyl ammonium salt with malondialdehyde tetramethylacetal in the presence of zinc chloride. The same procedure was used for the preparation of a new derivative, 2-methylthieno[2,3-b]pyridine, starting from 2-methyl-5-nitrothiophene. The thienopyridines were used in the synthesis of coordination compounds. Chlorides, isothiocyanates, acetates, and chloroacetates of copper(II), nickel(II), or cobalt(II) were used as starting salts. The prepared complexes were characterized by elemental analysis and FT IR. Structures of the four complexes were determined by single-crystal X-ray diffraction analysis.

Download Full-text