The Definition of the Elderly in Terms of Long Term Survival Rate of Patients Operated on for Colorectal Cancer.

Background: Treatment options for advanced gastric esophageal cancer are quite limited. Chemotherapy is unavoidable at certain stages, and research on targeted therapies has mostly failed. The advent of immunotherapy has brought hope for the treatment of advanced gastric esophageal cancer. The aim of the study was to analyze the safety of anti-PD-1/PD-L1 immunotherapy and the long-term survival of patients who were diagnosed as gastric esophageal cancer and received anti-PD-1/PD-L1 immunotherapy. Method: Studies on anti-PD-1/PD-L1 immunotherapy of advanced gastric esophageal cancer published before February 1, 2020 were searched online. The survival (e.g. 6-month overall survival, 12-month overall survival (OS), progression-free survival (PFS), objective response rates (ORR)) and adverse effects of immunotherapy were compared to that of control therapy (physician’s choice of therapy). Results: After screening 185 studies, 4 comparative cohort studies which reported the long-term survival of patients receiving immunotherapy were included. Compared to control group, the 12-month survival (OR = 1.67, 95% CI: 1.31 to 2.12, P < 0.0001) and 18-month survival (OR = 1.98, 95% CI: 1.39 to 2.81, P = 0.0001) were significantly longer in immunotherapy group. The 3-month survival rate (OR = 1.05, 95% CI: 0.36 to 3.06, P = 0.92) and 18-month survival rate (OR = 1.44, 95% CI: 0.98 to 2.12, P = 0.07) were not significantly different between immunotherapy group and control group. The ORR were not significantly different between immunotherapy group and control group (OR = 1.54, 95% CI: 0.65 to 3.66, P = 0.01). Meta-analysis pointed out that in the PD-L1 CPS ≥10 sub group population, the immunotherapy could obviously benefit the patients in tumor response rates (OR = 3.80, 95% CI: 1.89 to 7.61, P = 0.0002). Conclusion: For the treatment of advanced gastric esophageal cancer, the therapeutic efficacy of anti-PD-1/PD-L1 immunotherapy was superior to that of chemotherapy or palliative care.

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Long-term survival of patients with unresectable colorectal cancer liver metastases following infusional chemotherapy with 5-fluorouracil, leucovorin, oxaliplatin and surgery

Annals of Oncology ◽

10.1023/a:1008347829017 ◽

1999 ◽

Vol 10 (6) ◽

pp. 663-669 ◽

Cited By ~ 446

Author(s):

S. Giacchetti ◽

M. Itzhaki ◽

G. Gruia ◽

R. Adam ◽

R. Zidani ◽

...

Keyword(s):

Colorectal Cancer ◽

Liver Metastases ◽

Colorectal Cancer Liver Metastases ◽

Term Survival ◽

Long Term Survival

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Bacterial Translocation May Influence the Long-Term Survival in Colorectal Cancer Patients

Diseases of the Colon & Rectum ◽

10.1007/s10350-006-0827-4 ◽

2007 ◽

Vol 50 (3) ◽

pp. 323-330 ◽

Cited By ~ 15

Author(s):

Kin F. Chin ◽

R. Kallam ◽

Colm OʼBoyle ◽

John MacFie

Keyword(s):

Colorectal Cancer ◽

Cancer Patients ◽

Bacterial Translocation ◽

Term Survival ◽

Long Term Survival ◽

Colorectal Cancer Patients

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Perioperative blood transfusions reduce long-term survival following surgery for colorectal cancer

Diseases of the Colon & Rectum ◽

10.1007/bf02235758 ◽

1998 ◽

Vol 41 (4) ◽

pp. 451-459 ◽

Cited By ~ 64

Author(s):

Tom-H. Edna ◽

Tormod Bjerkeset

Keyword(s):

Colorectal Cancer ◽

Blood Transfusions ◽

Term Survival ◽

Long Term Survival

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Liver and Pancreatic Resection in the Elderly

HPB Surgery ◽

10.1155/1997/84160 ◽

1997 ◽

Vol 10 (4) ◽

pp. 259-261 ◽

Cited By ~ 2

Author(s):

O. J. Garden

Keyword(s):

Survival Rate ◽

Liver Resection ◽

Mortality Rate ◽

Elderly Patients ◽

Complication Rate ◽

Pancreatic Resection ◽

The Elderly ◽

Term Survival ◽

Pancreatic Resections

Background: Liver resection, or pancreaticoduodenectomy, has traditionally been thought to have a high morbidity and. mortality rate among the elderly. Recent improvements in surgical and anesthetic techniques, an increasing number of elderly patients, and an increasing need to justify use of limited health care resources prompted an assessment of recent surgical outcomes.Methods: Five hundred seventy-seven liver resections (July 1985–July 1994) performed for metastatic colorectal cancer and 488 pancreatic resections (October 1983–July 1994) performed for pancreatic malignancies were identified in departmental data bases. Outcomes of patients younger than age 70 years were compared with those of patients age 70 years or older.Results: Liver resection for 128 patients age 70 years or older resulted in a 4% perioperative. mortality rate and a 42% complication rate. Median hospital stay was 13 days, and 8% of the patients required admission to the intensive care unit (ICU). Median survival was 40 months, and the 5-year survival rate was 35%. No difference were found between results for the elderly and those for younger patients who had undergone liver resection, except for a minimally shorter hospital stay fortheyoungerpatients (median, 12 days vs. 13 days p=0.003). Pancreatic resection for 138 elderly patients resulted in a mortality rate of 6% and a complication rate of 45%. Median stay was 20 days, and 19% of the patients required ICU admission, results identical to those for the younger cohort. Long-term survival was poorer for the elderly patients, with a 5-year survival rate of 21% compared with 29% for the younger cohort (p=0.03).Conclusions: Major liver or pancreatic resections can be performed for the elderly with acceptable morbidity and mortality rates and possible long-term survival. Chronologic age alone is not a contraindication to liver or pancreatic resection for malignancy.

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Long-term survival rate of teeth receiving multidisciplinary endodontic, periodontal and prosthodontic treatments

Journal of Oral Rehabilitation ◽

10.1111/joor.12136 ◽

2014 ◽

Vol 41 (3) ◽

pp. 236-242 ◽

Cited By ~ 6

Author(s):

A. S. Moghaddam ◽

G. Radafshar ◽

M. Taramsari ◽

F. Darabi

Keyword(s):

Survival Rate ◽

Term Survival ◽

Long Term Survival

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