scholarly journals A CASE OF HIGHLY MALIGNANT GASTROINTESTINAL STROMAL TUMOR WITH METASTASIS OF THE RIGHT ADRENAL GLAND

2003 ◽  
Vol 64 (3) ◽  
pp. 657-662
Author(s):  
Hisashi IMAI ◽  
Takashi SUHARA ◽  
Yoshiyuki SASAKI ◽  
Harumi TAKAHASHI ◽  
Shigetoyo SAJI
Keyword(s):  
Adrenal Gland ◽  
Gastrointestinal Stromal Tumor ◽  
Stromal Tumor ◽  
The Right

scholarly journals Gastrointestinal stromal tumor resulting in recurrent colic in a arabian horse gelding a report of case

2020 ◽  
Vol 4 (1) ◽  
pp. 048-050
Author(s):  
Briceño Abelardo Morales ◽  
Oliva Harmon
Keyword(s):  
Gastrointestinal Stromal Tumor ◽  
Body Condition Score ◽  
Vital Signs ◽  
Abdominal Ultrasound ◽  
Stromal Tumor ◽  
Normal Limits ◽  
Eosinophilic Cytoplasm ◽  
Arabian Horse ◽  
The Right ◽  
Adjacent Segments

Background: A Grey 12-year-old Arabian endurance horse gelding was referred to the SHS Veterinary Center for anorexia, mild colic of 5 days duration, and melena of 1 day duration. The owner reported recurring colic, 12 episodes of mild colic in the previous year. Methods: On admission, vital signs were within normal limits and body condition score was estimated to be 3/9. Results: Packed cell volume (PCV) was 28% [reference range (RR): 31% to 47%] and plasma total protein was 58 g/L (RR: 60 to 80 g/L). Hematochezia was observed. Abdominal ultrasound examination detected no abnormalities. Over the next 12 h, the horse experienced hematochezia and several mild episodes of colic and death. A necropsy was performed. A mass arising from the right dorsal ascending colon near the base of the cecum and extending transmurally from the colonic mucosa into the mesocolon was a 8 cm × 5 cm × 8 cm firm, homogenous, tan mass. The portion of the mass that extended into the colonic lumen was pedunculated, with an ulcerated surface. The adjacent segments of colon were markedly reddened and edematous. Histologically, the mass was comprised of large interweaving sheets of small, spindle cells with ill-defined cell borders embedded in abundant myxomatous matrix. Tumor cells contained scant eosinophilic cytoplasm and oval to elongate nuclei with finely stippled chromatin and inconspicuous nucleoli. Mitotic figures were rare (1/10) high power fields. Tumor infiltrated between the muscularis interna and the muscularis externa at the myenteric plexi. Conclusion: Gross and histologic appearance, were consistent with a diagnosis of gastrointestinal stromal tumor.

scholarly journals A Case Presentation of Gastrointestinal Stromal Tumor of Duodenum

2021 ◽  
Vol 5 (1) ◽  
pp. 49-53
Author(s):  
Aamir Ghazanfar ◽  
Afifa Asghar ◽  
Farrukh Zaman ◽  
Hassan Mumtaz ◽  
Shahzeb Habib ◽  
...  
Keyword(s):  
Gastrointestinal Stromal Tumor ◽  
Abdominal Distension ◽  
Stromal Tumor ◽  
Palpable Mass ◽  
Case Presentation ◽  
Complete Surgical Resection ◽  
Abdominal Examination ◽  
Duodenal Gists ◽  
The Right ◽  
Common Mesenchymal Tumor

A gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor of the gastrointestinal tract. It is caused by the mutation in KIT and PDGFRα genes. It constitutes <1% of all gastrointestinal tumors. Duodenal GISTs constitute 4.5% of all GISTs. We report a 61-year-old lady, presented with generalized abdominal pain, vomiting, abdominal distension, and nausea for the last 3 years. Physical exam-ination showed a pallor and on abdominal examination, a large palpable mass was extending from the pelvis to the right upper quadrant of the abdomen. The CT scan showed a large heterogeneously echogenic mass in the abdomen and pelvis with no lymphadenopathy and distant metastasis in this region. Laparotomy showed a large globular mass extending from the pelvis to the right upper quadrant of the abdomen adherent to the wall of a third part of the duodenum. Complete surgical resection of tumor done with an intact capsule. Microscopic examination showed neoplastic spindle cells with tumor necrosis. An immunohistochemical study confirmed GIST.

scholarly journals Giant liver hemangioma in patient with ileal gastrointestinal stromal tumor

2014 ◽  
Vol 67 (1-2) ◽  
pp. 55-59
Author(s):  
Vasilije Antic ◽  
Marjan Micev ◽  
Danijela Baskic ◽  
Violeta Mladenovic
Keyword(s):  
Gastrointestinal Tract ◽  
Gastrointestinal Stromal Tumor ◽  
Gastrointestinal Stromal Tumors ◽  
Stromal Tumor ◽  
Surgical Removal ◽  
Liver Hemangioma ◽  
Palpable Mass ◽  
Gastrointestinal Malignancies ◽  
Stromal Tumors ◽  
The Right

Introduction. Gastrointestinal stromal tumors are the most common mesenchymal neoplasms of the gastrointestinal tract. These tumors represent more than 80% of all mesenchymal tumors found in the gastrointestinal tract, though they account for only approximately 3% of all gastrointestinal malignancies. Literature offers case reports, which describe symptomatic gastrointestinal stromal tumors and they generally represent patients with larger tumors. Case report. We present the case of a small gastrointestinal stromal tumor in a 40-year-old man, with associated giant liver hemangioma and fever, and with history of abdominal discomfort and fever. Clinical examination revealed hepatosplenomegaly, palpable mass in the right lower abdomen, and signs of neurofibromatosis type 1 (Morbus von Recklinghausen). Computed tomography revealed a giant tumor in the right lobe of the liver. Magnetic resonance showed abscess in the hemangioma of the liver. An intestinal tumor was incidentally found and excised during surgical laparotomy. An intestinal gastrointestinal stromal tumor was revealed by histopathology and confirmed by immunohistochemistry. Although a multidisciplinary team proposed surgical removal of the liver tumor mass, the surgeons decided to follow up the patient because of a high risk of new intervention. Conclusion. According to the available data, this is a very rare case of small intestinal gastrointestinal stromal tumor, with symptoms of fever and giant abscess in the liver hemangioma.

scholarly journals Primary hepatic gastrointestinal stromal tumor with right adrenal gland invasion

Medicine ◽  
2019 ◽  
Vol 98 (20) ◽  
pp. e15482 ◽  
Author(s):  
Liangliang Xu ◽  
Ming Zhang ◽  
Mingqing Xu
Keyword(s):  
Adrenal Gland ◽  
Gastrointestinal Stromal Tumor ◽  
Stromal Tumor

scholarly journals Gastrointestinal Stromal Tumor: A Case Report

2016 ◽  
Vol 4 (3) ◽  
pp. 120-122
Author(s):  
Stefan Krstevski
Keyword(s):  
Gastrointestinal Stromal Tumor ◽  
Imaging Techniques ◽  
Specific Antigen ◽  
Complete Removal ◽  
Exploratory Laparotomy ◽  
Stromal Tumor ◽  
Large Tumor ◽  
Gold Standard Method ◽  
Reduce Mortality Rate ◽  
The Right

Background: Gastrointestinal stromal tumor (GIST) is a rare gastrointestinal tumor but the most common mesenchymal tumor. It originates in the interstitial cells of Cajal, which on their own membranes have a specific antigen designated as CD117 or KIT receptor, a reliable indicator of tumor detection and therapy. Case: We reported a case of a 63-year-old male patient, who presented with symptoms of severe abdominal pain, discomfort, and secondary anemia. After a physical examination and a CT scan of the abdomen with angiography, the presence of a large tumor in the right hypochondrium was detected. Blood tests showed a high C-reactive protein and low hemoglobin. The patient had an exploratory laparotomy on his abdomen with complete removal of the tumor growth, which was then histologically analyzed. The obtained result from the histological analysis showed a high-degree of GIST. Conclusion: Early diagnosis of GISTs is of paramount importance to reduce mortality rate. This requires good background in pathobiology and knowledge of the physical manifestations of this malignant tumor. When this is combined with various imaging techniques, it becomes the gold standard method for GIST diagnosis.

scholarly journals A Case of a Gastrointestinal Stromal Tumor Diagnosed at the Postpartum Period

2016 ◽  
Vol 2016 ◽  
pp. 1-4
Author(s):  
Sefa Kurt ◽  
Aras Emre Canda ◽  
Emre Karadeniz ◽  
Tugba Yavuzsen ◽  
Ozgul Sagol ◽  
...  
Keyword(s):  
High Risk ◽  
Gastrointestinal Stromal Tumor ◽  
Side Wall ◽  
Stromal Tumor ◽  
Sufficient Information ◽  
En Bloc ◽  
Jejunal Segment ◽  
Abdominal Examination ◽  
The Right

Introduction. We discuss a rare gastrointestinal stromal tumor (GIST) case detected at the 10th postpartum week and we want to pay attention to the challenges and improvements in the diagnosis, surgery, chemotherapy, and follow-up of this rare tumor accompanied with the review of the current literature. Case Presentation. A 32-year-old multiparous woman presented with abdominal swelling 10 weeks after her second vaginal birth. Abdominal examination revealed a mass starting from the pelvic level and extending to the right upper quadrant. Radiological examinations showed a solid, multiloculated, and hypervascular mass starting from the pelvis and extending to the transverse colon. En bloc mass with a 20 cm jejunal segment resection and a left pelvic side wall peritonectomy with omentectomy was performed. The pathologic examination revealed a high-risk GIST which originated from the jejunum and disseminated to the peritoneum. The patient has been given imatinib 400 mg/day since then. She did not reveal any progression during the 15-month follow-up postoperatively. Conclusion. GIST tumors are rare and there is not sufficient information in the literature regarding its management. In this patient having high risk GIST and GIST sarcomatosis we successfully treated the patient by surgery and adjuvant imatinib chemotherapy.

scholarly journals Huge Metastatic Gastrointestinal Stromal Tumor Occupying the Right Ventricle

2018 ◽  
Vol 82 (5) ◽  
pp. 1469-1470
Author(s):  
Yudai Tamura ◽  
Hayato Tada ◽  
Hiroki Kato ◽  
Kenji Iino ◽  
Kenshi Hayashi ◽  
...  
Keyword(s):  
Right Ventricle ◽  
Gastrointestinal Stromal Tumor ◽  
Stromal Tumor ◽  
The Right

scholarly journals Single Surgical Approach for Gastric Gastrointestinal Stromal Tumor and Cholecystolitiasis by Laparoscopic Procedure

2021 ◽  
Vol 15 (4) ◽  
pp. 216
Author(s):  
Abdul Mughni ◽  
Vito Mahendra Ekasaputra ◽  
Siti Amarwati
Keyword(s):  
Gastrointestinal Stromal Tumor ◽  
Wedge Resection ◽  
Tumor Resection ◽  
Partial Gastrectomy ◽  
Early Mobilization ◽  
Gastric Fundus ◽  
Minimal Invasive ◽  
Stromal Tumor ◽  
Gastrointestinal Neoplasms ◽  
The Right

Introduction: Gastrointestinal stromal tumor (GIST) is a rare neoplasm representing 80% of gastrointestinal neoplasms. Laparoscopic resection is only recommended for GIST less than 2 cm and 5 cm for laparoscopic wedge resection. Thus, a large GIST is recommended to complete resection through laparotomy. A large GIST of the gastric fundus can be found in patients, which coincides with an upper right abdominal quadrant pain caused by cholecystolithiasis. A suggested laparotomy for tumor resection and cholecystectomy may result in poor recovery in the postoperative period. Therefore, one approach surgery with minimally invasive laparoscopic partial gastrectomy using Endoflex stapler and cholecystectomy was performed to achieve the optimal outcome.Case Presentation: A 43-year-old male had a major complaint of hematemesis and melena for one month and colicky pain in the right upper quadrant of the abdomen with increased intensity in the last two months. Contrast-enhanced abdominal MSCT revealed a solid 4.6 x 4 x 5.6 cm exophytic mass on the gastric fundus, added with 0.5 cm gall bladder stone. Laparoscopic partial gastrectomy and cholecystectomy were performed in a single minimal invasive surgical procedure. The post-operative period was uneventful. The patient experienced minimum pain, early mobilization, and better diet tolerance. He was discharged on day four after the surgery. Besides, the histopathologic result revealed a malignant mesenchymal tumor according to GIST with a tumor-free margin of resection.Conclusions: Single approach surgery with minimal laparoscopic partial gastrectomy and cholecystectomy has provided optimal outcomes for patients with large GIST and cholecystolithiasis.

Secondary Amyloidosis and Gastrointestinal Stromal Tumors

2003 ◽  
Vol 127 (4) ◽  
pp. 470-473
Author(s):  
Kerith Overstreet ◽  
Robert M. Barone ◽  
Howard S. Robin
Keyword(s):  
Adrenal Gland ◽  
Gastrointestinal Stromal Tumor ◽  
Gastrointestinal Stromal Tumors ◽  
Stromal Tumor ◽  
Secondary Amyloidosis ◽  
Coagulative Necrosis ◽  
Stromal Tumors ◽  
Amyloid Deposits ◽  
Congo Red Staining ◽  
Mitotic Figures

Abstract A 69-year-old man presented with a malignant gastrointestinal stromal tumor associated with secondary amyloidosis. The tumor had classic features of a malignant gastrointestinal stromal tumor with interlacing fascicles and whorls of spindled cells, numerous and conspicuous mitotic figures, and extensive coagulative necrosis. The cells stained diffusely for CD117 (c-Kit), confirming the diagnosis of gastrointestinal stromal tumor. The spleen, 1 adrenal gland, and part of the pancreas were removed en block with the stomach. By microscopy, the spleen and adrenal gland were partially replaced with amyloid deposits confirmed by Congo red staining, electron microscopy, and immunohistochemistry. In contrast, neither the tumor nor the surrounding vasculature showed amyloid deposition. To our knowledge, this represents only the second case of systemic amyloidosis associated with a gastrointestinal stromal tumor. This case is unique in that extensive, diffuse amyloid deposits were observed in the spleen, adrenal gland, and liver.

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