Developments in mycotoxin analysis: an update for 2010-2011

2012 ◽  
Vol 5 (1) ◽  
pp. 3-30 ◽  
Author(s):  
G. Shephard ◽  
F. Berthiller ◽  
P. Burdaspal ◽  
C. Crews ◽  
M. Jonker ◽  
...  
Keyword(s):  
Analytical Method ◽  
Analytical Methods ◽  
Method Development ◽  
Rapid Development ◽  
Ergot Alkaloids ◽  
Alternaria Toxins ◽  
Research Publications ◽  
Mycotoxin Analysis ◽  
The Subject ◽  
Conventional Methods

This review highlights developments in mycotoxin analysis and sampling over a period between mid-2010 and mid-2011. It covers the major mycotoxins: aflatoxins, Alternaria toxins, ergot alkaloids, fumonisins, ochratoxin, patulin, trichothecenes, and zearalenone. Analytical methods for mycotoxins continue to be developed and published. Despite much interest in immunochemical methods and in the rapid development of LC-MS methodology, more conventional methods, sometimes linked to novel clean-up protocols, have also been the subject of research publications over the above period. Occurrence of mycotoxins falls outside the main focus of this review; however, where relevant to analytical method development, this has been mentioned.

Developments in mycotoxin analysis: an update for 2018-19

2020 ◽  
Vol 13 (1) ◽  
pp. 3-24 ◽  
Author(s):  
S.A. Tittlemier ◽  
B. Cramer ◽  
C. Dall’Asta ◽  
M.H. Iha ◽  
V.M.T. Lattanzio ◽  
...  
Keyword(s):  
Critical Review ◽  
Analytical Methods ◽  
Ergot Alkaloids ◽  
Mass Spectrometric ◽  
Sampling Strategies ◽  
Alternaria Toxins ◽  
Recent Developments ◽  
Mycotoxin Analysis

This review summarises developments on the analysis of various matrices for mycotoxins that have been published in the period from mid-2018 to mid-2019. Analytical methods to determine aflatoxins, Alternaria toxins, ergot alkaloids, fumonisins, ochratoxins, patulin, trichothecenes, and zearalenone are covered in individual sections. Advances in sampling strategies are also discussed in a dedicated section. In addition, developments in multi-mycotoxin methods – including comprehensive mass spectrometric-based methods as well as simple immunoassays – are also reviewed. This critical review aims to briefly present the most important recent developments and trends in mycotoxin determination as well as to address limitations of the presented methodologies.

Developments in mycotoxin analysis: an update for 2014-2015

2016 ◽  
Vol 9 (1) ◽  
pp. 5-30 ◽  
Author(s):  
F. Berthiller ◽  
C. Brera ◽  
C. Crews ◽  
M.H. Iha ◽  
R. Krska ◽  
...  
Keyword(s):  
Critical Review ◽  
Analytical Methods ◽  
Ergot Alkaloids ◽  
Sampling Strategies ◽  
New Methods ◽  
Alternaria Toxins ◽  
Mycotoxin Analysis ◽  
Proper Sampling

This review summarises developments in the determination of mycotoxins over a period between mid-2014 and mid-2015. In tradition with previous articles of this series, analytical methods to determine aflatoxins, Alternaria toxins, ergot alkaloids, fumonisins, ochratoxins, patulin, trichothecenes and zearalenone are covered in individual sections. Advances in proper sampling strategies are discussed in a dedicated section, as are new methods used to analyse botanicals and spices and newly developed LC-MS based multi-mycotoxin methods. The critical review aims to briefly discuss the most important developments and trends in mycotoxin determination as well as to address shortcomings of current methodologies.

Developments in mycotoxin analysis: an update for 2017-2018

2019 ◽  
Vol 12 (1) ◽  
pp. 3-29 ◽  
Author(s):  
S.A. Tittlemier ◽  
B. Cramer ◽  
C. Dall’Asta ◽  
M.H. Iha ◽  
V.M.T. Lattanzio ◽  
...  
Keyword(s):  
Critical Review ◽  
Analytical Methods ◽  
Ergot Alkaloids ◽  
Mass Spectrometric ◽  
Sampling Strategies ◽  
Alternaria Toxins ◽  
Recent Developments ◽  
Mycotoxin Analysis ◽  
Liquid Chromatographic ◽  
Chromatographic Mass

This review summarises developments that have been published in the period from mid-2017 to mid-2018 on the analysis of various matrices for mycotoxins. Analytical methods to determine aflatoxins, Alternaria toxins, ergot alkaloids, fumonisins, ochratoxins, patulin, trichothecenes, and zearalenone are covered in individual sections. Advances in sampling strategies are discussed in a dedicated section, as are methods used to analyse botanicals and spices, and newly developed comprehensive liquid chromatographic-mass spectrometric based multi-mycotoxin methods. This critical review aims to briefly discuss the most important recent developments and trends in mycotoxin determination as well as to address limitations of the presented methodologies.

Developments in mycotoxin analysis: an update for 2016-2017

2018 ◽  
Vol 11 (1) ◽  
pp. 5-32 ◽  
Author(s):  
F. Berthiller ◽  
B. Cramer ◽  
M.H. Iha ◽  
R. Krska ◽  
V.M.T. Lattanzio ◽  
...  
Keyword(s):  
Critical Review ◽  
Analytical Methods ◽  
Ergot Alkaloids ◽  
Sampling Strategies ◽  
Alternaria Toxins ◽  
Recent Developments ◽  
Mycotoxin Analysis ◽  
Proper Sampling

This review summarises developments in the determination of mycotoxins over a period between mid-2016 and mid-2017. Analytical methods to determine aflatoxins, Alternaria toxins, ergot alkaloids, fumonisins, ochratoxins, patulin, trichothecenes and zearalenone are covered in individual sections. Advances in proper sampling strategies are discussed in a dedicated section, as are methods used to analyse botanicals and spices and newly developed LC-MS based multi-mycotoxin methods. This critical review aims to briefly discuss the most important recent developments and trends in mycotoxin determination as well as to address limitations of the presented methodologies.

Developments in mycotoxin analysis: an update for 2013-2014

2015 ◽  
Vol 8 (1) ◽  
pp. 5-35 ◽  
Author(s):  
F. Berthiller ◽  
C. Brera ◽  
C. Crews ◽  
M.H. Iha ◽  
R. Krsha ◽  
...  
Keyword(s):  
Sample Preparation ◽  
Analytical Methods ◽  
Ergot Alkaloids ◽  
Time Span ◽  
New Methods ◽  
Alternaria Toxins ◽  
Mycotoxin Analysis ◽  
Proper Sampling

This review highlights developments in the determination of mycotoxins over a period between mid-2013 and mid-2014. It continues in the format of the previous articles of this series, emphasising on analytical methods to determine aflatoxins, Alternaria toxins, ergot alkaloids, fumonisins, ochratoxins, patulin, trichothecenes and zearalenone. The importance of proper sampling and sample preparation is briefly addressed in a dedicated section, while another chapter summarises new methods used to analyse botanicals and spices. As LC-MS/MS instruments are becoming more and more widespread in the determination of multiple classes of mycotoxins, another section is focusing on such newly developed multi-mycotoxin methods. While the wealth of published methods during the 12 month time span makes it impossible to cover every single one, this exhaustive review nevertheless aims to address and briefly discuss the most important developments and trends.

Developments in mycotoxin analysis: an update for 2015-2016

2017 ◽  
Vol 10 (1) ◽  
pp. 5-29 ◽  
Author(s):  
F. Berthiller ◽  
C. Brera ◽  
M.H. Iha ◽  
R. Krska ◽  
V.M.T. Lattanzio ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Critical Review ◽  
Analytical Methods ◽  
Ergot Alkaloids ◽  
Sampling Strategies ◽  
Liquid Chromatography Mass Spectrometry ◽  
Recent Developments ◽  
Mycotoxin Analysis

This review summarises developments in the determination of mycotoxins over a period between mid-2015 and mid-2016. Analytical methods to determine aflatoxins, Alternaria toxins, ergot alkaloids, fumonisins, ochratoxins, patulin, trichothecenes and zearalenone are covered in individual sections. Advances in proper sampling strategies are discussed in a dedicated section, as are methods used to analyse botanicals and spices and newly developed liquid chromatography mass spectrometry based multi-mycotoxin methods. This critical review aims to briefly discuss the most important recent developments and trends in mycotoxin determination as well as to address limitations of presented methodologies.

A Review: Method Development Validation and Degradation Studies of some Anticancer Drugs

2021 ◽  
pp. 5443-5448
Author(s):  
Punna Venkateshwarlu ◽  
Mehul M. Patel
Keyword(s):  
Liquid Chromatography ◽  
Anticancer Drugs ◽  
Analytical Method ◽  
Analytical Methods ◽  
Bioanalytical Methods ◽  
Method Development ◽  
Estimation Methods ◽  
Simultaneous Estimation ◽  
Pharmaceutical Dosage Forms ◽  
Stability Indicating

This article reviews the various analytical methods reported so far in the literature for the determination of stability and impurity profile the lenalidomide and palbociclib anti cancer drugs in single or combination with other drugs in bulk, pharmaceutical dosage forms, biological fluids, stability indicating and impurity profiling methods. The analytical methods used for the estimation of lenalidomide and palbociclib anticancer drugs reviewed in this paper includes ultraviolet spectrophotometry,high performance liquid chromatography (HPLC) ,ultra performance liquid chromatography (UPLC) ,liquid chromatography-mass spectrometry (LC-MS) and electrophoresis. This review focus on the effect of all chromatographic parameters so as to provide as fast, reliable and cost effective methodology of testing. Method development is the process of proving that analytical method is acceptable for use to measure the concentration of active pharmaceutical ingredient in a specific compound dosage form which must be validated to provide reliable data for regulatory submissions. This reviewed is mainly on analytical method development and validation, stability indicating methods, simultaneous estimation methods and bioanalytical methods. The review covers the time period from 2007 to 2019 during which analytical methods including all types of spectrophotometric and chromatographic techniques were reported. The Review covers lenalidomide and palbociclib API and formulation analytical and bioanalytical methods.

scholarly journals Implementing Green Analytical Methodologies Using Solid-Phase Microextraction: A Review

Molecules ◽  
2020 ◽  
Vol 25 (22) ◽  
pp. 5297
Author(s):  
Kayla M. Billiard ◽  
Amanda R. Dershem ◽  
Emanuela Gionfriddo
Keyword(s):  
Analytical Chemistry ◽  
Sample Preparation ◽  
Analytical Method ◽  
Analytical Methods ◽  
Solid Phase Microextraction ◽  
Method Development ◽  
Assessment Tool ◽  
Solid Phase ◽  
Assessment Tools ◽  
Green Analytical Chemistry

Implementing green analytical methodologies has been one of the main objectives of the analytical chemistry community for the past two decades. Sample preparation and extraction procedures are two parts of analytical method development that can be best adapted to meet the principles of green analytical chemistry. The goal of transitioning to green analytical chemistry is to establish new methods that perform comparably—or superiorly—to traditional methods. The use of assessment tools to provide an objective and concise evaluation of the analytical methods’ adherence to the principles of green analytical chemistry is critical to achieving this goal. In this review, we describe various sample preparation and extraction methods that can be used to increase the greenness of a given analytical method. We gave special emphasis to modern microextraction technologies and their important contributions to the development of new green analytical methods. Several manuscripts in which the greenness of a solid-phase microextraction (SPME) technique was compared to other sample preparation strategies using the Green Analytical Procedure Index (GAPI), a green assessment tool, were reviewed.

Beware of Bar Charts for Plotting Calibration Curves for Analytical Method Development

2020 ◽  
Vol 103 (5) ◽  
pp. 1424-1425
Author(s):  
Ali Shayanfar
Keyword(s):  
Analytical Method ◽  
Analytical Methods ◽  
Method Development ◽  
Linear Range ◽  
Scientific Journals ◽  
Calibration Curves ◽  
Scatter Plots

Abstract Some researchers, in their published articles in authentic scientific journals, plot calibration curves using bar charts instead of scatter plots using common software such as Excel. Bar charts can significantly affect the apparent linear range and sensitivity of the developed method, and using bar charts as calibration curves gives the wrong results. Therefore, this issue should be considered by researchers in developing analytical methods.

Developments in mycotoxin analysis: an update for 2009-2010

2011 ◽  
Vol 4 (1) ◽  
pp. 3-28 ◽  
Author(s):  
G. Shephard ◽  
F. Berthiller ◽  
P. Burdaspal ◽  
C. Crews ◽  
M. Jonker ◽  
...  
Keyword(s):  
Ergot Alkaloids ◽  
Natural Occurrence ◽  
Individual Laboratory ◽  
Alternaria Toxins ◽  
Main Emphasis ◽  
Mycotoxin Analysis ◽  
Novel Method ◽  
The Individual ◽  
Improved Methods

This review highlights developments in mycotoxin analysis and sampling over a period between mid-2009 and mid-2010. It covers the major mycotoxins aflatoxins, Alternaria toxins, ergot alkaloids, fumonisins, ochratoxin, patulin, trichothecenes, and zearalenone. New and improved methods for mycotoxins continue to be published. Immunological-based method developments continue to be of wide interest in a broad range of formats. Multimycotoxin determination by LC-MS/MS is now being targeted at the specific ranges of mycotoxins and matrices of interest or concern to the individual laboratory. Although falling outside the main emphasis of the review, some aspects of natural occurrence have been mentioned, especially if linked to novel method developments.

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