Antioxidative Potential of Ocimum gratissimum and Ocimum canum Leaf Polyphenols and Protective Effects on Some Pro-Oxidants Induced Lipid Peroxidation in Rat Brain: An in vitro Study

2008 ◽  
Vol 3 (5) ◽  
pp. 325-334 ◽  
Author(s):  
Ganiyu Oboh
2021 ◽  
Vol 40 (4) ◽  
pp. 1519-1529
Author(s):  
Elena Galluccio ◽  
Serena Spadoni ◽  
Barbara Fontana ◽  
Emanuele Bosi ◽  
Piermarco Piatti ◽  
...  

2012 ◽  
Vol 2 (3) ◽  
pp. 10-19 ◽  
Author(s):  
Sheri-Ann Tan ◽  
Sonia Ramos ◽  
María Angeles Martin ◽  
Raquel Mateos ◽  
Michael Harvey ◽  
...  

2010 ◽  
Vol 2010 ◽  
pp. 1-6 ◽  
Author(s):  
E. R. Milaeva ◽  
S. I. Filimonova ◽  
N. N. Meleshonkova ◽  
L. G. Dubova ◽  
E. F. Shevtsova ◽  
...  

The antioxidative activity of ferrocenes bearing either 2,6-di-tert-butylphenol or phenyl groups has been compared using DPPH (1,1-diphenyl-2-picrylhydrazyl) test and in the study of the in vitro impact on lipid peroxidation in rat brain homogenate and on some characteristics of rat liver mitochondria. The results of DPPH test at20∘C show that the activity depends strongly upon the presence of phenolic group but is improved by the influence of ferrocenyl fragment. The activity of N-(3,5-di-tert-butyl-4-hydroxyphenyl)iminomethylferrocene (1), for instance, was 88.4%, which was higher than the activity of a known antioxidant 2,6-di-tert-butyl-4-methylphenol (BHT) (48.5%), whereas the activity of N-phenyl-iminomethylferrocene2was almost negligible−2.9%. The data obtained demonstrate that the compounds with 2,6-di-tert-butylphenol moiety are significantly more active than the corresponding phenyl analogues in the in vitro study of lipid peroxidation in rat brain homogenate. Ferrocene1performs a promising behavior as an antioxidant and inhibits the calcium-dependent swelling of mitochondria. These results allow us to propose the potential cytoprotective (neuroprotective) effect of ditopic compounds containing antioxidant 2,6-di-tert-butylphenol group and redox active ferrocene fragment.


2004 ◽  
Vol 101 (2) ◽  
pp. 117-132 ◽  
Author(s):  
Kari Seppänen ◽  
Pasi Soininen ◽  
Jukka T. Salonen ◽  
Simo Lötjönen ◽  
Reino Laatikainen

Oncology ◽  
1995 ◽  
Vol 52 (1) ◽  
pp. 66-68 ◽  
Author(s):  
M. Chitra ◽  
E. Sukumar ◽  
C.S. Shyamala Devi

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