POLYMETHYLMETHACRYLATE-ANTIBLASTIC DRUG COMPOUNDS: AN IN VITRO STUDY ASSESSING THE CYTOTOXIC EFFECT IN CANCER CELL LINES-A NEW METHOD FOR LOCAL CHEMOTHERAPY OF BONE METASTASIS

Orthopedics ◽  
1992 ◽  
Vol 15 (2) ◽  
pp. 189-194
Author(s):  
Francesco Greco ◽  
Luigi de Palma ◽  
Nicola Specchia ◽  
Stefano Jacobelli ◽  
Cristiana Gaggini
Keyword(s):  
Bone Metastasis ◽  
Cell Lines ◽  
Cancer Cell ◽  
Cytotoxic Effect ◽  
In Vitro Study ◽  
Cancer Cell Lines ◽  
New Method ◽  
Local Chemotherapy ◽  
Drug Compounds

scholarly journals Platinum (IV)-fatty acid conjugates overcome inherently and acquired Cisplatin resistant cancer cell lines: an in-vitro study

BMC Cancer ◽  
2016 ◽  
Vol 16 (1) ◽  
Author(s):  
Einav Ratzon ◽  
Yousef Najajreh ◽  
Rami Salem ◽  
Hazem Khamaisie ◽  
Martin Ruthardt ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Cell Lines ◽  
Cancer Cell ◽  
In Vitro Study ◽  
Cancer Cell Lines ◽  
Vitro Study

scholarly journals In vitro study of combined cilengitide and radiation treatment in breast cancer cell lines

2013 ◽  
Vol 8 (1) ◽  
Author(s):  
Tim Lautenschlaeger ◽  
James Perry ◽  
David Peereboom ◽  
Bin Li ◽  
Ahmed Ibrahim ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Radiation Treatment ◽  
In Vitro Study ◽  
Cancer Cell Lines ◽  
Vitro Study ◽  
Breast Cancer Cell Lines

scholarly journals An in vitro study on the effect of synthesized tin(IV) complexes on glioblastoma, colorectal, and skin cancer cell lines

2016 ◽  
Vol 1 (1) ◽  
pp. 7-15 ◽  
Author(s):  
Jennie L Williams ◽  
Lesley C Lewis-Alleyne ◽  
Melinda Solomon ◽  
Long Nguyen ◽  
Robert Johnson ◽  
...  
Keyword(s):  
Skin Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
In Vitro Study ◽  
Cancer Cell Lines ◽  
Vitro Study

scholarly journals NEW QUINAZOLINONE DERIVATIVES: SYTHESIS AND IN VITRO CYTOTOXIC ACTIVITY

2020 ◽  
Vol 58 (1) ◽  
pp. 12
Author(s):  
Tran Khac Vu
Keyword(s):  
Cytotoxic Activity ◽  
Cell Lines ◽  
Cancer Cell ◽  
Cytotoxic Effect ◽  
Cancer Cell Lines ◽  
Ic50 Values ◽  
Quinazolinone Derivatives ◽  
Bioassay Result ◽  
Mcf 7

The paper presents a simple synthesis of new quinazolinone derivatives 13a-i. Synthesized derivatives were tested for their cytotoxic effect against three cancer cell lines including SKLU-1, MCF-7 and HepG-2. The bioassay result showed that only compound 13e exhibited significant cytotoxic effect against cancer cell lines tested with IC50 values of 9.48, 20.39 and 18.04 µg/ mL, respectively.

scholarly journals An In Vitro Estimation of the Cytotoxicity and Genotoxicity of Root Extract from Leonurus sibiricus L. Overexpressing AtPAP1 against Different Cancer Cell Lines

Molecules ◽  
2018 ◽  
Vol 23 (8) ◽  
pp. 2049 ◽  
Author(s):  
Przemysław Sitarek ◽  
Ewelina Synowiec ◽  
Tomasz Kowalczyk ◽  
Tomasz Śliwiński ◽  
Ewa Skała
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Cytotoxic Effect ◽  
Treatment Success ◽  
Cancer Cell Lines ◽  
Nadh:Ubiquinone Oxidoreductase ◽  
Cytotoxic Activities ◽  
Root Extract ◽  
Root Extracts

As the current cancer treatment success rate is not sufficient, interest has grown in plants as possible sources of anti-cancer compounds. One such plant with a broad spectrum of activity is Lenourus sibiricus of the family Lamiaceae. This study investigates for the first time both the genotoxic and cytotoxic activities of TR (transformed) and AtPAP1 TR (with over-expression of transcriptional factor) root extracts of Lenourus sibiricus against various cancer cell lines (CCRF-CEM, K-562 and A549). Both tested extracts showed a cytotoxic effect on CCRF-CEM and K-562 cell lines, but strongest activity was observed for the AtPAP1 TR extract. No cytotoxic effect was observed against the A549 cell line in the tested concentration range, and it was found that both tested extracts may induce apoptosis by decreasing mitochondrial membrane potential and inducing nDNA damage lesion in the TP53 region and mtDNA in ND1 (mitochondrially encoded NADH: ubiquinone oxidoreductase core subunit 1) and ND5 (mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5) regions in K-562 and CCRF-CEM. Our results confirmed that TR and AtPAP1 TR root extracts from L. sibiricus are cytotoxic and genotoxic against different model cell lines (CCRF-CEM and K-562). However, the observed genotoxicity of both extracts needs to be confirmed by additional studies. These preclinical observations support the use of L. sibiricus with other pharmacological purposes.

scholarly journals PP118—In vitro study of sonodynamic and photodynamic treatment on human cancer cell lines

2013 ◽  
Vol 35 (8) ◽  
pp. e51-e52 ◽  
Author(s):  
F. Foglietta ◽  
R. Canaparo ◽  
A. Francovich ◽  
P. Civera ◽  
L. Serpe
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Human Cancer ◽  
In Vitro Study ◽  
Cancer Cell Lines ◽  
Vitro Study ◽  
Human Cancer Cell ◽  
Photodynamic Treatment ◽  
Human Cancer Cell Lines

scholarly journals Cytotoxic Effect of Datura stramonium Extract on Cancer Cell lines

2010 ◽  
Vol 34 (1) ◽  
pp. 131-138
Author(s):  
Ala'a H. Merza
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Cytotoxic Effect ◽  
Datura Stramonium ◽  
Cancer Cell Lines ◽  
Brain Cell ◽  
Mammary Adenocarcinoma ◽  
Normal Rat ◽  
Embryonic Fibroblast

In order to investigate the in vitro antitumor activity of Datura stramonium seeds on cancer cell lines. Extract of this plant was prepared by using different concentrations of seed extract 3, 3.25, 3.5, 3.75, 4, 4.25, 4.5, 4.75 and 5 mg/ ml. Cytotoxicity was estimated on mammary adenocarcinoma (AMN3), brain cancer, and normal rat embryonic fibroblast (Ref3) cell lines. The results exhibited that the extract has cytotoxic effect by decreasing the viability of AMN3 (42.91%) and brain cell lines (32.79%). However, it produced little effect on viability of normal cell line Ref3, indicating the specificity of this extract against malignant cells

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