Status of Choriocapillaris in Fellow Eyes of Patients With Unilateral Retinal Vein Occlusions

Актуальность. В структуре сосудистой патологии глаза в последние годы отмечается неуклонное повышение частоты окклюзий ретинальных вен (ОРВ), преимущественно у женщин молодого возраста. Цель. Исследовать особенности хориоретинальной гемодинамики при ОРВ у женщин молодого возраста. Материал и методы. Отобрано 15 женщин (15 глаз) с ОРВ в возрасте от 35 до 45 лет (39,7±4 года). Группа контроля была сформирована 20 соматически здоровыми женщинами сопоставимого возраста. Изучались показатели линейной скорости кровотока в задних коротких цилиарных артериях: максимальная систолическая скорость (Vmax, см/с), конечная диастолическая скорость (Vmin, см/с), средняя скорость (Vmed, см/с), индекс резистентности или периферического сопротивления (RI), пульсационный индекс (PI). Исследовались показатели макулярного кровотока: общая средняя плотность поверхностного сосудистого сплетения (ОПС, %), площадь аваскулярной зоны сетчатки (ПАЗ, мм2), субфовеолярная толщина хориоидеи (СТХ, мкм). Результаты. В основной группе показатели Vmax, Vmin, Vmed, PI, RI оказались статистически значимо ниже группы контроля, составив: 8,29±0,64 см/с, 2,64±0,24 см/с, 4,52±0,35 см/с; 1,245±0,06 и 0,68±0,02 против: 13,32±0,64 см/с, 5,02±0,70 см/с, 7,92±0,74 см/с; 1,022±0,06 и 0,62±0,03 соответственно (р<0,001). Выявлены также и характерные изменения показателей макулярного кровотока: ОПС и СТХ оказались статистически значимо ниже по сравнению с контрольной группой – 44,47±3,08 % и 248±7 мкм против 54,73±2,4 % и 285±18 мкм соответственно (p<0,001). При этом в основной группе отмечалось увеличение площади аваскулярной зоны: ПАЗ – 0,366±0,020 мм2 против 0,267±0,097 мм2 в контроле соответственно (p=0,007). В основной группе ОРВ клинически проявлялись формированием зон капиллярной неперфузии, интраретинальных геморрагий, «ватообразных» экссудатов по ходу пораженной сосудистой аркады, увеличением площади аваскулярной зоны. Выводы. Выявленные статистически значимые снижения показателей хориоретинальной гемодинамики и клинические проявления ОРВ у женщин молодого возраста свидетельствуют о склонности их развития, преимущественно по ишемическому типу.

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Elevated levels of Merkel cell polyoma virus in the anophthalmic conjunctiva

Scientific Reports ◽

10.1038/s41598-021-92642-w ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Nora Siegal ◽

Michal Gutowski ◽

Lakshmi Akileswaran ◽

Norman J. Beauchamp ◽

Lien-Chieh Ding ◽

...

Keyword(s):

Ocular Surface ◽

Copy Number ◽

Clinical Importance ◽

Polyoma Virus ◽

Merkel Cell ◽

Fellow Eye ◽

16S Rdna Pcr ◽

The Impact ◽

Merkel Cell Polyoma Virus ◽

Fellow Eyes

AbstractThe human ocular surface hosts a paucibacterial resident microbiome and virome. The factors contributing to homeostasis of this mucosal community are presently unknown. To determine the impact of ocular enucleation and prosthesis placement on the ocular surface microbiome, we sampled conjunctival swabs from 20 anophthalmic and 20 fellow-eye intact conjunctiva. DNA was extracted and subjected to quantitative 16S rDNA PCR, biome representational karyotyping (BRiSK), and quantitative PCR (qPCR) confirmation of specific organisms. 16S ribosomal qPCR revealed equivalent bacterial loads between conditions. Biome representational in silico karyotyping (BRiSK) demonstrated comparable bacterial fauna between anophthalmic and intact conjunctiva. Both torque teno virus and Merkel cell polyoma virus (MCPyV) were detected frequently in healthy and anophthalmic conjunctiva. By qPCR, MCPyV was detected in 19/20 anophthalmic samples compared with 5/20 fellow eyes. MCPyV copy number averaged 891 copies/ng in anophthalmic conjunctiva compared with 193 copies/ng in fellow eyes (p < 0.001). These results suggest that enucleation and prosthesis placement affect the ocular surface flora, particularly for the resident virome. As MCPyV has been shown to be the etiologic cause of Merkel cell carcinoma, understanding the mechanisms by which the ocular surface regulates this virus may have clinical importance.

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Macular Pigment Optical Density and Photoreceptor Outer Segment Length as Predisease Biomarkers for Age-Related Macular Degeneration

Journal of Clinical Medicine ◽

10.3390/jcm9051347 ◽

2020 ◽

Vol 9 (5) ◽

pp. 1347 ◽

Cited By ~ 1

Author(s):

Norihiro Nagai ◽

Sakiko Minami ◽

Misa Suzuki ◽

Hajime Shinoda ◽

Toshihide Kurihara ◽

...

Keyword(s):

Macular Degeneration ◽

Optical Density ◽

Outer Segment ◽

Macular Pigment ◽

Age Related Macular Degeneration ◽

Segment Length ◽

Macular Pigment Optical Density ◽

Photoreceptor Outer Segment ◽

Age Related ◽

Fellow Eyes

To explore predisease biomarkers, which may help screen for the risk of age-related macular degeneration (AMD) at very early stages, macular pigment optical density (MPOD) and photoreceptor outer segment (PROS) length were analyzed. Thirty late AMD fellow eyes, which are at high risk and represent the predisease condition of AMD, were evaluated and compared with 30 age-matched control eyes without retinal diseases; there was no early AMD involvement in the AMD fellow eyes. MPOD was measured using MPS2® (M.E. Technica Co. Ltd., Tokyo, Japan), and PROS length was measured based on optical coherence tomography images. MPOD levels and PROS length in the AMD fellow eyes were significantly lower and shorter, respectively, than in control eyes. MPOD and PROS length were positively correlated in control eyes (R = 0.386; p = 0.035) but not in AMD fellow eyes. Twenty (67%) AMD fellow eyes met the criteria of MPOD < 0.65 and/or PROS length < 35 μm, while only five (17%) control eyes did. After adjusting for age and sex, AMD fellow eyes more frequently satisfied the definition (p < 0.001; 95% confidence interval, 3.50–60.4; odds ratio, 14.6). The combination of MPOD and PROS length may be a useful biomarker for screening predisease AMD patients, although further studies are required in this regard.

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Changes in each retinal layer and ellipsoid zone recovery after full-thickness macular hole surgery

Scientific Reports ◽

10.1038/s41598-021-90955-4 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Min-Woo Lee ◽

Tae-Yeon Kim ◽

Yong-Yeon Song ◽

Seung-Kook Baek ◽

Young-Hoon Lee

Keyword(s):

Macular Hole ◽

Axial Length ◽

Outer Nuclear Layer ◽

Plexiform Layer ◽

Retinal Layer ◽

Inner Plexiform Layer ◽

Full Thickness ◽

Ellipsoid Zone ◽

Full Thickness Macular Hole ◽

Fellow Eyes

AbstractTo analyze the changes in each retinal layer and the recovery of the ellipsoid zone (EZ) after full-thickness macular hole (FTMH) surgery. Patients who underwent surgery for FTMH were included. Spectral-domain optical coherence tomography (SD-OCT) was performed preoperatively and postoperatively at 1, 3, 6, 9, and 12 months. A total of 32 eyes were enrolled. Ganglion cell layer, inner plexiform layer, and inner nuclear layer showed significant reductions over time after surgery (P = 0.020, P = 0.001, and P = 0.001, respectively), but were significantly thicker than those of fellow eyes at 12 months postoperatively. The average recovery duration of the external limiting membrane (ELM), outer nuclear layer (ONL), and EZ was 1.5, 2.1, and 6.1 months, respectively. Baseline best-corrected visual acuity (BCVA) (P = 0.003), minimum linear diameter (MLD) (P = 0.025), recovery of EZ (P = 0.008), and IRL thickness (P < 0.001) were significant factors associated with changes in the BCVA. Additionally, axial length (P < 0.001), MLD (P = 0.020), and IRL thickness (P = 0.001) showed significant results associated with EZ recovery. The IRL gradually became thinner after FTMH surgery but was still thicker than that of the fellow eye at 12 months postoperatively. The recovery of ELM and ONL may be a prerequisite for the EZ recovery. The BCVA change was affected by baseline BCVA, MLD, recovery of EZ, and IRL thickness. Additionally, axial length, MLD, and IRL thickness were significantly associated with EZ recovery.

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The Spectrum of Central Choriocapillaris Abnormalities on Swept-Source Optical Coherence Tomography Angiography in the Fellow Eye of Unilateral Exudative Age-Related Macular Degeneration Patients: From Flow Deficits to Subclinical Non-Exudative Neovascularization

Journal of Clinical Medicine ◽

10.3390/jcm10122658 ◽

2021 ◽

Vol 10 (12) ◽

pp. 2658

Author(s):

Alexis Khorrami Kashi ◽

Eric Souied ◽

Selim Fares ◽

Enrico Borrelli ◽

Vittorio Capuano ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Macular Degeneration ◽

Optical Coherence Tomography Angiography ◽

Clinical Findings ◽

Age Related Macular Degeneration ◽

Optical Coherence ◽

Swept Source ◽

Exudative Amd ◽

Age Related ◽

Fellow Eyes

We evaluated the spectrum of choriocapillaris (CC) abnormalities in the fellow eyes of unilateral exudative age-related macular degeneration (AMD) patients using swept-source optical coherence tomography angiography (SS-OCTA). Fellow eyes of unilateral exudative AMD patients were prospectively included between May 2018 and October 2018. Patients underwent a multimodal imaging including a SS-OCTA. Demographics and clinical findings were analyzed. The estimated prevalence of macular neovascularization (MNV) was computed. Number and size of flow deficits (FDs) and percentage of flow deficits (FD%) were computed on the compensated CC flow images with the Fiji software. We included 97 eyes of 97 patients (mean age was 80 ± 7.66 years, 39 males, 58 females). The prevalence of MNV in the studied eyes was 8.25% (8/97 eyes). In the 89 non-neovascular eyes, FD% averaged 45.84% ± 11.63%, with a corresponding total area of FDs of 4.19 ± 1.12 mm2. There was a higher prevalence of drusenoid pigment epithelial detachment in eyes with subclinical neovascularization (p = 0.021). Fellow eyes with unilateral exudative AMD encompassed a series of CC abnormalities, from FDs of the aging CC to subclinical non-exudative MNV.

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Non-infectious uveitis affecting the posterior segment treated with fluocinolone acetonide intravitreal implant: 3-year fellow eye analysis

Eye ◽

10.1038/s41433-021-01608-9 ◽

2021 ◽

Author(s):

Carlos Pavesio ◽

Carsten Heinz

Keyword(s):

Cataract Surgery ◽

Treatment Strategies ◽

Standard Of Care ◽

Fluocinolone Acetonide ◽

Posterior Segment ◽

Recurrence Rates ◽

Intravitreal Implant ◽

Infectious Uveitis ◽

Dose Corticosteroid ◽

Fellow Eyes

Abstract Background Prevention of non-infectious uveitis of the posterior segment (NIU-PS) recurrence using 0.2 μg/day fluocinolone acetonide implant (FAi) was assessed over 3 years (NCT01694186). Outcomes for FAi-treated and fellow eyes with NIU-PS were compared, to evaluate FAi versus conventional treatment strategies. Methods Eligible subjects had >1-year recurrent NIU-PS history and either ≥2 separate recurrences requiring treatment, or corticosteroid therapy (systemic or ocular) in the 12 months preceding study entry. Bilateral disease was present and analysed in 59/87 FAi-treated participants. Recurrence rates, best-corrected visual acuity (BCVA) changes, cataract surgery, intraocular pressure (IOP) events and adjunctive medication use were compared for FAi-treated and fellow eyes. Results Over 36 months, more FAi-treated than fellow eyes remained recurrence-free (28.8% vs. 5.1%, P = 0.001; mean 1.9 vs. 4.7 recurrences, respectively, P < 0.0001). FAi-treated eyes gained +9.6 letters BCVA, versus a loss of −4.4 in fellow eyes (P < 0.0001). Systemic medications were given to 42.4% of subjects. Intra/periocular adjunctive injections were lower in FAi-treated than fellow eyes (20.3% vs. 66.1%, P < 0.0001); topical corticosteroid use was also lower in FAi-treated than fellow eyes (27.1% vs 52.5%, P = 0.0041). IOP-related events occurred at similar rates in both FAi-treated and fellow eyes, excepting IOP-lowering surgery (5.1% vs. 15.3%, respectively; P = 0.1251). Cataract surgery occurred in 72.0% of FAi-treated and 37.0% of fellow eyes. Conclusions In subjects with bilateral NIU-PS, continuous, low-dose corticosteroid with 0.2 μg/day FAi reduced recurrence and adjunctive medication requirements, and improved vision over 36 months, providing greater protection against ocular inflammation than a reactive approach using standard of care.

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Detecting subclinical keratoconus by biomechanical analysis in tomographically regular keratoconus fellow eyes

European Journal of Ophthalmology ◽

10.1177/11206721211063740 ◽

2021 ◽

pp. 112067212110637

Author(s):

Victor A Augustin ◽

Hyeck-Soo Son ◽

Isabella Baur ◽

Ling Zhao ◽

Gerd U Auffarth ◽

...

Keyword(s):

Visual Acuity ◽

Central Corneal Thickness ◽

Corneal Thickness ◽

Case Series ◽

Biomechanical Analysis ◽

Corvis St ◽

Corrected Visual Acuity ◽

The Mean ◽

Best Corrected Visual Acuity ◽

Fellow Eyes

Purpose To analyze the tomographically non-affected second eyes of keratoconus patients using the Corvis ST to detect any biomechanical abnormalities or subclinical keratoconus. Methods In this retrospective, single-center, consecutive case series 244 eyes of 122 keratoconus patients were analyzed between November 2020 and February 2021. Fourteen fellow eyes fulfilled the inclusion criteria and showed no clinical or tomographic signs of keratoconus. Main outcome measures included best-corrected visual acuity, tomographic and biomechanical analyses using Scheimpflug imaging: Pentacam and Corvis ST (Oculus, Wetzlar, Germany). Tomographic analyses included anterior and posterior simulated keratometry, K-Max, central corneal thickness, thinnest corneal thickness, Belin/Ambrosio Ectasia Display, and the ABCD grading system. For biomechanical analyses, the corneal biomechanical index (CBI) and tomographic biomechanical index were used. Results The mean best-corrected visual acuity was 0.01 ± 0.10 logMAR. Mean K-Max was 43.79 ± 1.12 D, mean central corneal thickness 529 ± 25 µm, mean thinnest corneal thickness 524 ± 23 µm, and mean Belin/Ambrosio Ectasia Display 1.0 ± 0.32. The mean CBI was 0.30 ± 0.21. Regular CBI values were found in six of 14 patients. The mean tomographic biomechanical index was 0.47 ± 0.22 with regular values observed in only two of 14 patients. No signs of tomographic or biomechanical abnormalities were shown in only one of 14 keratoconus fellow eyes, with regular ABCD, Belin/Ambrosio Ectasia Display, CBI and tomographic biomechanical index values. Conclusions Tomographically normal fellow eyes of keratoconus patients are rare. In these cases, a biomechanical analysis of the cornea may help detect a subclinical keratoconus. The tomographic biomechanical index was the most sensitive index to verify a mild ectasia.

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