scholarly journals Maternal Iron and Folic Acid Supplementation Is Associated with Lower Risk of Low Birth Weight in India

2013 ◽  
Vol 143 (8) ◽  
pp. 1309-1315 ◽  
Author(s):  
Yarlini Balarajan ◽  
S. V. Subramanian ◽  
Wafaie W. Fawzi
Keyword(s):  
Folic Acid ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Lower Risk ◽  
Folic Acid Supplementation ◽  
Acid Supplementation ◽  
Iron And Folic Acid ◽  
Maternal Iron

scholarly journals Association between iron and folic acid supplementation and birth weight in Ethiopia: systemic review and meta analysis

2021 ◽  
Vol 45 (1) ◽  
Author(s):  
Andualem Zenebe ◽  
Kaleab Tesfaye Tegegne ◽  
Berhanu Bifato ◽  
Abiyu Ayalew Assefa
Keyword(s):  
Folic Acid ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Meta Analysis ◽  
Folic Acid Supplementation ◽  
Systemic Review ◽  
Cochrane Library ◽  
Main Body ◽  
Acid Supplementation ◽  
Iron And Folic Acid

Abstract Background Previous studies on iron with folic acid supplementation and low birth weight indicated different findings. The aim of the current systemic review and meta-analysis was to examine the relationship between iron and folic acid supplementation and birth weight in Ethiopia. Main body The databases searched were PubMed, Google Scholar, Web of Science and Cochrane Library in January 2021. AZ, KTT and AAA carried out the data extraction and independently assessed the articles for inclusion in the review using risk-of-bias tool guided by PRISMA checklist. The combined Odds ratio with 95% confidence interval was calculated using random effect model. Twenty four observational studies involving 10,989 participants, 2423 newborns who were born LBW were included. The combined effect size (OR) for low birth weight comparing women who have Iron and Folic acid supplementation versus women who did not have iron and folic acid supplementation was 0.39 (95% CI 0.27–0.59, p < 0.00001, I2 = 91%). There was significant heterogeneity (Q = 264.16, I2 = 91%, p < 0.00001). No publication bias was observed (Egger’s test: p = 0.742, Begg’s test: p = 0.372). Overall 69.5% of women reported having iron and folic acid supplementation during current pregnancy. And the overall proportion of low birth weight was 22.1%. Conclusions Women who were supplied with iron and folic acid during pregnancy had a 67% decreased chance of delivering low birth weight new born in Ethiopia.

scholarly journals Periconception folic acid supplementation, fetal growth and the risks of low birth weight and preterm birth: the Generation R Study

2009 ◽  
Vol 102 (5) ◽  
pp. 777-785 ◽  
Author(s):  
Sarah Timmermans ◽  
Vincent W. V. Jaddoe ◽  
Albert Hofman ◽  
Régine P. M. Steegers-Theunissen ◽  
Eric A. P. Steegers
Keyword(s):  
Folic Acid ◽  
Birth Weight ◽  
Preterm Birth ◽  
Low Birth Weight ◽  
The Netherlands ◽  
Fetal Growth ◽  
Late Pregnancy ◽  
Folic Acid Supplementation ◽  
Folic Acid Supplement ◽  
Acid Supplementation

Countries worldwide, including the Netherlands, recommend that women planning pregnancy use a folic acid supplement during the periconception period. Some countries even fortify staple foods with folic acid. These recommendations mainly focus on the prevention of neural tube defects, despite increasing evidence that folic acid may also influence birth weight. We examined whether periconception folic acid supplementation affects fetal growth and the risks of low birth weight, small for gestational age (SGA) and preterm birth, in the Generation R Study in Rotterdam, the Netherlands. Main outcome measures were fetal growth measured in mid- and late pregnancy by ultrasound, birth weight, SGA and preterm birth in relation to periconception folic supplementation (0·4–0·5 mg). Data on 6353 pregnancies were available. Periconception folic acid supplementation was positively associated with fetal growth. Preconception folic acid supplementation was associated with 68 g higher birth weight (95 % CI 37·2, 99·0) and 13 g higher placental weight (95 % CI 1·1, 25·5), compared to no folic acid supplementation. In these analyses parity significantly modified the effect estimates. Start of folic acid supplementation after pregnancy confirmation was associated with a reduced risk of low birth weight (OR 0·61, 95 % CI 0·40, 0·94). Similarly, reduced risks for low birth weight and SGA were observed for women who started supplementation preconceptionally, compared to those who did not use folic acid (OR 0·43, 95 % CI 0·28, 0·69 and OR 0·40, 95 % CI 0·22, 0·72). In conclusion, periconception folic acid supplementation is associated with increased fetal growth resulting in higher placental and birth weight, and decreased risks of low birth weight and SGA.

ERRATA

PEDIATRICS ◽  
1979 ◽  
Vol 64 (6) ◽  
pp. 945-945
Keyword(s):  
Folic Acid ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Folic Acid Supplementation ◽  
Low Birth Weight Infants ◽  
Acid Supplementation

In the article "Folic Acid Supplementation in Low Birth Weight Infants," by Stevens et al (Pediatrics 64:333-335, 1979) two corrections were received after the journal went to press. In Table 1, RCF values should read ng/ml not µg/ml. On page 335, first column, line 21, RCF levels should read less than 100 ng/ml not 100 µg/ml.

scholarly journals Assessment of different folic acid supplementation doses for low-birth-weight infants

2016 ◽  
Vol 51 (4) ◽  
pp. 210-216 ◽  
Author(s):  
Fatma Cakmak Celik ◽  
Canan Aygun ◽  
Sedat Gulten ◽  
Abdulkerim Bedir ◽  
Erhan Cetinoglu ◽  
...  
Keyword(s):  
Folic Acid ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Folic Acid Supplementation ◽  
Low Birth Weight Infants ◽  
Acid Supplementation

Folic Acid Supplementation in Low Birth Weight Infants

PEDIATRICS ◽  
1979 ◽  
Vol 64 (3) ◽  
pp. 333-335 ◽  
Author(s):  
David Stevens ◽  
David Burman ◽  
M. Keith Strelling ◽  
Audrey Morris
Keyword(s):  
Folic Acid ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Acid Group ◽  
Folic Acid Supplementation ◽  
Folate Intake ◽  
Red Cell ◽  
Low Birth Weight Infants ◽  
Acid Supplementation ◽  
Significant Difference

Low birth weight infants(246) entered a trial of folic acid supplementation from 3 weeks to 12 months of age. The folic acid group had significantly higher mean hemoglobin levels at 6 and 9 months of age but the differences were only about 0.5 gm/dl, there was no significant difference in hematocrit, and in both groups of infants the mean hemoglobin levels were higher than those of normal birth weight infants. The differences in hemoglobin, although statistically significant, are of uncertain clinical significance. Median red cell folate levels remained within the normal adult range in both groups of infants. A minority of infants in the untreated group had low red cell folate levels but this was usually temporary, corrected by dietary folate, and not associated with low hemoglobin. Weight gain was not affected by folic acid supplementation. The infants in this trial were fed with a milk preparation containing 3.5 µg/100 ml of folic acid which is a similar concentration to that of human milk and we recommend that the folate content of milks fed to low birth weight infants should not fall below this level. We do not have sufficient grounds to recommend routine folic acid supplements for all low birth weight infants throughout the first year of life but there is a possibility that their folate intake may sometimes be suboptimal.

scholarly journals A review of the maternal iron and folic acid supplementation programme in Nepal: Achievements and challenges

2021 ◽  
Author(s):  
Naveen Paudyal ◽  
Kedar Raj Parajuli ◽  
Vanessa Garcia Larsen ◽  
Ramesh Kant Adhikari ◽  
Madhu Dixit Devkota ◽  
...  
Keyword(s):  
Folic Acid ◽  
Folic Acid Supplementation ◽  
Acid Supplementation ◽  
Iron And Folic Acid ◽  
Maternal Iron

Impact of iron and folic acid supplementation on oxidative stress during pregnancy

2015 ◽  
Vol 35 (8) ◽  
pp. 803-806 ◽  
Author(s):  
E. Lymperaki ◽  
A. Tsikopoulos ◽  
K. Makedou ◽  
E. Paliogianni ◽  
L. Kiriazi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Folic Acid ◽  
Folic Acid Supplementation ◽  
Acid Supplementation ◽  
Iron And Folic Acid

scholarly journals Adherence to iron and folic acid supplementation and associated factors among antenatal care attendants in Northwest Ethiopia

2020 ◽  
Vol 9 (1) ◽  
pp. 20
Author(s):  
Berhanu Abebaw Mekonnen ◽  
Yadeta Dessie ◽  
Negga Baraki ◽  
Abdu Oumer ◽  
Mehari Gebru
Keyword(s):  
Folic Acid ◽  
Antenatal Care ◽  
Folic Acid Supplementation ◽  
Northwest Ethiopia ◽  
Adherence Rate ◽  
P Value ◽  
Cross Sectional ◽  
Acid Supplementation ◽  
Iron And Folic Acid ◽  
Pregnant Mothers

<p>Iron and folic acid supplementation is the key approach for anemia prevention and control during pregnancy. In Ethiopia only &lt;1% of pregnant mothers ingest the ideal number of tablets. Although, adherence is the most important challenge, literature is dearth and the predictors are undoubtedly recognized. Institution based quantitative cross sectional study design triangulated with qualitative methods was employed among 395 systematically selected pregnant mothers attending antenatal care in Debre Markos town, Ethiopia. Data were collected using interviewer administered structured questionnaire. Data were entered into Epi data and exported to SPSS software. Bivariate and multivariable Logistic regression with the 95% confidence interval was computed. P-value &lt; 0.05 was declared as statistically significant. Eight in-depth interviews were conducted. The data were entered and analyzed using open code software. Adherence rate was 55.5% (95%CI, 50.5%-60.4%). Pregnant mothers who had; history of anemia during current pregnancy [AOR:7.9, 95%CI (4.44-14.01)], primary education (AOR:4.0, 95%CI (1.88-8.54)], secondary education and above (AOR:3.6, 95%CI (1.20-6.94)], good knowledge of iron and folic acid supplementation [AOR:2.1, 95%CI (1.24-3.56)], and early registration for antenatal care (AOR:1.8, 95%CI (1.06-3.11)] were predictors of iron and folic acid supplementation adherence. The rate of adherence was low. Getting medical advice and fear of illness if missed were the primary reasons that enforce mothers to take the tablets. Hence, improving mothers’ knowledge regarding overall aspects of the tablet through better advice, community teaching and the mass media at large, would improve adherence.</p>

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