Folic Acid Supplementation in Low Birth Weight Infants

PEDIATRICS ◽  
1979 ◽  
Vol 64 (3) ◽  
pp. 333-335 ◽  
Author(s):  
David Stevens ◽  
David Burman ◽  
M. Keith Strelling ◽  
Audrey Morris
Keyword(s):  
Folic Acid ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Acid Group ◽  
Folic Acid Supplementation ◽  
Folate Intake ◽  
Red Cell ◽  
Low Birth Weight Infants ◽  
Acid Supplementation ◽  
Significant Difference

Low birth weight infants(246) entered a trial of folic acid supplementation from 3 weeks to 12 months of age. The folic acid group had significantly higher mean hemoglobin levels at 6 and 9 months of age but the differences were only about 0.5 gm/dl, there was no significant difference in hematocrit, and in both groups of infants the mean hemoglobin levels were higher than those of normal birth weight infants. The differences in hemoglobin, although statistically significant, are of uncertain clinical significance. Median red cell folate levels remained within the normal adult range in both groups of infants. A minority of infants in the untreated group had low red cell folate levels but this was usually temporary, corrected by dietary folate, and not associated with low hemoglobin. Weight gain was not affected by folic acid supplementation. The infants in this trial were fed with a milk preparation containing 3.5 µg/100 ml of folic acid which is a similar concentration to that of human milk and we recommend that the folate content of milks fed to low birth weight infants should not fall below this level. We do not have sufficient grounds to recommend routine folic acid supplements for all low birth weight infants throughout the first year of life but there is a possibility that their folate intake may sometimes be suboptimal.

ERRATA

PEDIATRICS ◽  
1979 ◽  
Vol 64 (6) ◽  
pp. 945-945
Keyword(s):  
Folic Acid ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Folic Acid Supplementation ◽  
Low Birth Weight Infants ◽  
Acid Supplementation

In the article "Folic Acid Supplementation in Low Birth Weight Infants," by Stevens et al (Pediatrics 64:333-335, 1979) two corrections were received after the journal went to press. In Table 1, RCF values should read ng/ml not µg/ml. On page 335, first column, line 21, RCF levels should read less than 100 ng/ml not 100 µg/ml.

scholarly journals Assessment of different folic acid supplementation doses for low-birth-weight infants

2016 ◽  
Vol 51 (4) ◽  
pp. 210-216 ◽  
Author(s):  
Fatma Cakmak Celik ◽  
Canan Aygun ◽  
Sedat Gulten ◽  
Abdulkerim Bedir ◽  
Erhan Cetinoglu ◽  
...  
Keyword(s):  
Folic Acid ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Folic Acid Supplementation ◽  
Low Birth Weight Infants ◽  
Acid Supplementation

scholarly journals Association between iron and folic acid supplementation and birth weight in Ethiopia: systemic review and meta analysis

2021 ◽  
Vol 45 (1) ◽  
Author(s):  
Andualem Zenebe ◽  
Kaleab Tesfaye Tegegne ◽  
Berhanu Bifato ◽  
Abiyu Ayalew Assefa
Keyword(s):  
Folic Acid ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Meta Analysis ◽  
Folic Acid Supplementation ◽  
Systemic Review ◽  
Cochrane Library ◽  
Main Body ◽  
Acid Supplementation ◽  
Iron And Folic Acid

Abstract Background Previous studies on iron with folic acid supplementation and low birth weight indicated different findings. The aim of the current systemic review and meta-analysis was to examine the relationship between iron and folic acid supplementation and birth weight in Ethiopia. Main body The databases searched were PubMed, Google Scholar, Web of Science and Cochrane Library in January 2021. AZ, KTT and AAA carried out the data extraction and independently assessed the articles for inclusion in the review using risk-of-bias tool guided by PRISMA checklist. The combined Odds ratio with 95% confidence interval was calculated using random effect model. Twenty four observational studies involving 10,989 participants, 2423 newborns who were born LBW were included. The combined effect size (OR) for low birth weight comparing women who have Iron and Folic acid supplementation versus women who did not have iron and folic acid supplementation was 0.39 (95% CI 0.27–0.59, p < 0.00001, I2 = 91%). There was significant heterogeneity (Q = 264.16, I2 = 91%, p < 0.00001). No publication bias was observed (Egger’s test: p = 0.742, Begg’s test: p = 0.372). Overall 69.5% of women reported having iron and folic acid supplementation during current pregnancy. And the overall proportion of low birth weight was 22.1%. Conclusions Women who were supplied with iron and folic acid during pregnancy had a 67% decreased chance of delivering low birth weight new born in Ethiopia.

scholarly journals The effect of folate fortification on folic acid-based homocysteine-lowering intervention and stroke risk: a meta-analysis

2014 ◽  
Vol 18 (8) ◽  
pp. 1514-1521 ◽  
Author(s):  
Rui Zeng ◽  
Chun-Hua Xu ◽  
Yuan-Ning Xu ◽  
Ya-Li Wang ◽  
Mian Wang
Keyword(s):  
Folic Acid ◽  
Randomized Controlled Trials ◽  
Stroke Risk ◽  
Meta Analysis ◽  
Folic Acid Supplementation ◽  
Folate Intake ◽  
Controlled Trials ◽  
Acid Supplementation ◽  
Randomized Controlled ◽  
Significant Difference

AbstractObjectiveFolate and vitamin B12 are two vital regulators in the metabolic process of homocysteine, which is a risk factor of atherothrombotic events. Low folate intake or low plasma folate concentration is associated with increased stroke risk. Previous randomized controlled trials presented discordant findings in the effect of folic acid supplementation-based homocysteine lowering on stroke risk. The aim of the present review was to perform a meta-analysis of relevant randomized controlled trials to check the how different folate fortification status might affect the effects of folic acid supplementation in lowering homocysteine and reducing stroke risk.DesignRelevant randomized controlled trials were identified through formal literature search. Homocysteine reduction was compared in subgroups stratified by folate fortification status. Relative risks with 95 % confidence intervals were used as a measure to assess the association between folic acid supplementation and stroke risk.SettingThe meta-analysis included fourteen randomized controlled trials,SubjectsA total of 39 420 patients.ResultsHomocysteine reductions were 26·99 (sd 1·91) %, 18·38 (sd 3·82) % and 21·30 (sd 1·98) %, respectively, in the subgroups without folate fortification, with folate fortification and with partial folate fortification. Significant difference was observed between the subgroups with folate fortification and without folate fortification (P=0·05). The relative risk of stroke was 0·88 (95 % CI 0·77, 1·00, P=0·05) in the subgroup without folate fortification, 0·94 (95 % CI 0·58, 1·54, P=0·82) in the subgroup with folate fortification and 0·91 (95 % CI 0·82, 1·01, P=0·09) in the subgroup with partial folate fortification.ConclusionsFolic acid supplementation might have a modest benefit on stroke prevention in regions without folate fortification.

scholarly journals Periconception folic acid supplementation, fetal growth and the risks of low birth weight and preterm birth: the Generation R Study

2009 ◽  
Vol 102 (5) ◽  
pp. 777-785 ◽  
Author(s):  
Sarah Timmermans ◽  
Vincent W. V. Jaddoe ◽  
Albert Hofman ◽  
Régine P. M. Steegers-Theunissen ◽  
Eric A. P. Steegers
Keyword(s):  
Folic Acid ◽  
Birth Weight ◽  
Preterm Birth ◽  
Low Birth Weight ◽  
The Netherlands ◽  
Fetal Growth ◽  
Late Pregnancy ◽  
Folic Acid Supplementation ◽  
Folic Acid Supplement ◽  
Acid Supplementation

Countries worldwide, including the Netherlands, recommend that women planning pregnancy use a folic acid supplement during the periconception period. Some countries even fortify staple foods with folic acid. These recommendations mainly focus on the prevention of neural tube defects, despite increasing evidence that folic acid may also influence birth weight. We examined whether periconception folic acid supplementation affects fetal growth and the risks of low birth weight, small for gestational age (SGA) and preterm birth, in the Generation R Study in Rotterdam, the Netherlands. Main outcome measures were fetal growth measured in mid- and late pregnancy by ultrasound, birth weight, SGA and preterm birth in relation to periconception folic supplementation (0·4–0·5 mg). Data on 6353 pregnancies were available. Periconception folic acid supplementation was positively associated with fetal growth. Preconception folic acid supplementation was associated with 68 g higher birth weight (95 % CI 37·2, 99·0) and 13 g higher placental weight (95 % CI 1·1, 25·5), compared to no folic acid supplementation. In these analyses parity significantly modified the effect estimates. Start of folic acid supplementation after pregnancy confirmation was associated with a reduced risk of low birth weight (OR 0·61, 95 % CI 0·40, 0·94). Similarly, reduced risks for low birth weight and SGA were observed for women who started supplementation preconceptionally, compared to those who did not use folic acid (OR 0·43, 95 % CI 0·28, 0·69 and OR 0·40, 95 % CI 0·22, 0·72). In conclusion, periconception folic acid supplementation is associated with increased fetal growth resulting in higher placental and birth weight, and decreased risks of low birth weight and SGA.

scholarly journals Folic Acid Supplementation on Fetal Growth at Different Gestational Ages

2021 ◽  
Vol 14 (4) ◽  
pp. 1761-1766
Author(s):  
Hannah Sugirthabai Rajila Rajendran ◽  
Thotakura Balaji ◽  
Jyothi Ashok Kumar ◽  
Santhosh Kumar ◽  
Vaithianathan Gnanasundaram
Keyword(s):  
Folic Acid ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Fetal Growth ◽  
Folic Acid Supplementation ◽  
Fetal Biometry ◽  
Vitamin B9 ◽  
Significant Difference ◽  
Low Birth Weight Babies ◽  
Positive Effect

Introduction: Folate, Vitamin B9, is found naturally in our day to day foods. It is vital for synthesis of DNA and normal cell division in humans. Studies have revealed constantly that maternal folic acid[FA] intake prior to and in early conception decreases neural tube defects. Aim: The aim of the current study is to evaluate the relationship between FA intake by the mother during conception and fetal growth at different gestational ages and also if, periconceptional and preconceptional FA intake has a positive effect on fetal growth, hence reducing the risk of low birth weight babies or small for gestational age (SGA) babies. Materials and methods: 180 pregnant women were classified based on their period of FA intake as preconception, periconception FA intake and nil FA intake. Standard fetal biometric parameters were measured using ultrasonogram during the 1st , 2nd and 3rd trimester of their pregnancy. Results: Preconception FA intake had a positive effect on fetal growth as compared to those who abstained from FA supplementation. Intake during preconception and peri-conception i.e. immediately after confirmation of pregnancy was found to have a reduced risk of low fetal weight as against those who did not consume FA. Fetal biometry showed significant difference between preconception and periconception groups. Conclusion: In conclusion, preconceptional and periconceptional FA supplementation of 0.4-0.5 mg/day was positively affecting fetal growth and caused an optimal birth weight by decreasing the incidence of low birth weight.

scholarly journals Penurunan Kecemasan Ibu dan Perbaikan Status Bangun-Tidur BBLR melalui Perawatan Metode Kanguru

2011 ◽  
Vol 14 (3) ◽  
pp. 193-198 ◽  
Author(s):  
Qori’Ila Saidah ◽  
Yeni Rustina ◽  
Nani Nurhaeni
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Kangaroo Mother Care ◽  
Maternal Anxiety ◽  
Friedman Test ◽  
Low Birth Weight Infants ◽  
Kangaroo Care ◽  
Consecutive Sampling ◽  
Significant Difference ◽  
Wake State

AbstrakKondisi klinis dan perawatan di ruang rawat intensif pada Bayi Berat Lahir Rendah (BBLR) mempengaruhi status banguntidurnyadan menyebabkan kecemasan pada ibu. Tujuan penelitian ini mengidentifikasi pengaruh perawatan metode kanguruterhadap kecemasan ibu dan status bangun-tidur BBLR. Rancangan penelitian one group pretest posttest design dengan sampel16 ibu dan BBLR di sebuah rumah sakit Surabaya secara consecutive sampling. Kecemasan ibu diukur dengan PSS: NICU danstatus bangun tidur dengan modifikasi skala Brazelton oleh Priya. Hasil analisis uji statistik menggunakan Wilcoxon Sign RankTest dan uji Friedman menunjukkan ada perbedaan bermakna (p= 0,000; α= 0,05). PMK mempunyai pengaruh signifikanterhadap perubahan kecemasan ibu dan status bangun-tidur BBLR. Tenaga kesehatan disarankan mengembangkan PMK untukpeningkatan status kesehatan ibu, juga tumbuh kembang bayi yang optimal.Kata kunci: kecemasan ibu, perawatan metode kangguru, status bangun-tidur BBLR.AbstractClinical condition and treatment at Low Birth Weight Infants (LBW) in the intensive care unit affects sleep-wake status andcauses anxiety for the mother. The aims of this study is to identify the influence of methods of kangaroo care on maternalanxiety and sleep-wake status of LBW. The design of this study was one group pretest posttest design with sample of 16 mothersand low birth weight in a hospital in Surabaya by consecutive sampling. Maternal anxiety was measured with the PSS: NICUand sleep-wake status with Brazelton scale modified by Priya. The result of statistical analysis test using Wilcoxon Sign RankTest and Friedman test showed there are significant difference (p= 0.000; α= 0.05). KMC has a significant influence onchanges in maternal anxiety and sleep-wake status of LBW. Health care provider are recommended to develop KMC forimprovement of maternal health status, as well as the optimal infant growth and development.Keywords: maternal anxiety, kangaroo mother care, sleep-wake state in low birth weight baby

scholarly journals The Effectiveness of Auditory Stimuli from Murottal Quran to Improve Comfort and Weight in Low Birth Weight Infants: Randomized Controlled Trial

Jurnal NERS ◽  
2019 ◽  
Vol 14 (1) ◽  
pp. 111
Author(s):  
Desriati Devi ◽  
Yeni Rustina ◽  
Defi Efendi
Keyword(s):  
Randomized Controlled Trial ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Controlled Trial ◽  
Auditory Stimuli ◽  
Control Groups ◽  
Low Birth Weight Infants ◽  
Randomized Controlled ◽  
Significant Difference ◽  
And Control

Introduction: Low birth weight (LBW) infants who have been hospitalized are exposed to various conditions that provoke discomfort, which could trigger a stress response and growth disorders. This study aimed to identify the effects of auditory stimuli from Murottal Quran when it comes to the comfort and weight of LBW infants.Methods: This study used a clinical randomized controlled trial design involving 52 low birth weight infants. The infants were randomly assigned to either the intervention group (n=26) or the control (n=26). The intervention of Murottal Quran was given using a speaker 4 times a day for 20 minutes every 3 hours. This intervention was conducted for three days.Results: The results of this study show that there is a significant difference in the comfort of  low birth weight infants after Murottal Qur’an on the first, second, and third days between the intervention and control groups (p=0.014; <0.001; <0.001). There was no significant difference in the weight between the intervention and control groups in the first, second, and third days (p=0.481; 0.481; 0.464).Conclusion: The auditory stimuli of Murottal Quran can help to improve the comfort level of low birth weight infants during hospitalization. It can therefore be used as a supportive therapy to facilitate low birth weight infant and premature infant development.

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