scholarly journals Dietary Modifications, Weight Loss, and Changes in Metabolic Markers Affect Global DNA Methylation in Hispanic, African American, and Afro-Caribbean Breast Cancer Survivors

2015 ◽  
Vol 145 (4) ◽  
pp. 783-790 ◽  
Author(s):  
Lissette Delgado-Cruzata ◽  
Wenfei Zhang ◽  
Jasmine A McDonald ◽  
Wei Yann Tsai ◽  
Cristina Valdovinos ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Dna Methylation ◽  
Weight Loss ◽  
African American ◽  
Cancer Survivors ◽  
Breast Cancer Survivors ◽  
Global Dna Methylation ◽  
Metabolic Markers ◽  
Dietary Modifications

Virtual weight loss program for African-American breast cancer survivors: Preliminary results.

2017 ◽  
Vol 35 (5_suppl) ◽  
pp. 163-163
Author(s):  
Jeanne M. Ferrante ◽  
Michelle Doose ◽  
Alicja Bator ◽  
Katie Devine ◽  
Pamela Ohman Strickland ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Weight Loss ◽  
African American ◽  
Cancer Survivors ◽  
Weight Change ◽  
Self Efficacy ◽  
Breast Cancer Survivors ◽  
Weight Loss Program

163 Background: Obesity is associated with higher breast cancer recurrence and death, and poorer health and quality of life. African-American (AA) women have the highest prevalence of obesity, obesity-related comorbidities, and breast cancer mortality compared with other racial/ethnic groups. Weight loss after breast cancer diagnosis may lower rates of recurrence and improve fitness, fatigue, and quality of life. Methods: This 6-month randomized controlled trial pilot-tests the use of a Fitbit activity tracker (Fitbit only group) versus Fitbit plus SparkPeople, a free web-based weight loss program (combined group) among 70 AA breast cancer survivors. Paired t-tests assess changes from baseline to 6-months among each participant in primary (weight, body mass index [BMI], percent body fat) and secondary (24-hour caloric intake, daily number of steps, quality of life, self-monitoring strategies, self-efficacy) outcomes. Two-group t-tests assess differences in outcomes between the two groups. Results: Currently, 36 of 46 (78.3%) eligible participants have enrolled and completed baseline assessments. Mean age of participants is 61.7 years (SD 8.7) and mean BMI is 36.9 (SD 7.0). Analyses of the first 25 participants who completed 3-month assessments (Fitbit only N = 12; combined group N = 13) show significant weight loss in both groups; Fitbit only: mean weight change -6.73 pounds, SD 4.61, p < 0.001; mean BMI change -0.96 kg/m2, SD 0.84, p = 0.002; combined group: mean weight change -5.95 pounds, SD 5.84, p = 0.003; mean BMI change -1.03 kg/m2, SD 0.77, p < 0.001. All participants significantly increased tracking of diet (Fitbit only p = 0.016; combined group p < 0.001) and physical activity (Fitbit only p < 0.001; combined group p = 0.001). Though not significant, combined group participants showed greater increases in self-efficacy for eating healthy and reducing fat and calories, and increases in daily steps (+1308 vs. +285 for Fitbit only group). Preliminary analyses show no statistically significant difference in changes in outcomes from baseline to 3 months between the two groups. Conclusions: Both programs show potential as convenient and efficient weight loss methods for African-American breast cancer survivors. Clinical trial information: NCT02699983.

scholarly journals Efficacy of a Weight Loss Intervention for African American Breast Cancer Survivors

2017 ◽  
Vol 35 (24) ◽  
pp. 2820-2828 ◽  
Author(s):  
Melinda Stolley ◽  
Patricia Sheean ◽  
Ben Gerber ◽  
Claudia Arroyo ◽  
Linda Schiffer ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Weight Loss ◽  
Body Composition ◽  
African American ◽  
Cancer Survivors ◽  
African American Women ◽  
Breast Cancer Survivors ◽  
Weight Loss Program ◽  
Behavioral Changes ◽  
Weight Loss Intervention

Purpose African American women with breast cancer have higher cancer-specific and overall mortality rates. Obesity is common among African American women and contributes to breast cancer progression and numerous chronic conditions. Weight loss interventions among breast cancer survivors positively affect weight, behavior, biomarkers, and psychosocial outcomes, yet few target African Americans. This article examines the effects of Moving Forward, a weight loss intervention for African American breast cancer survivors (AABCS) on weight, body composition, and behavior. Patients and Methods Early-stage (I-III) AABCS were randomly assigned to a 6-month interventionist-guided (n = 125) or self-guided (n = 121) weight loss program supporting behavioral changes to promote a 5% weight loss. Anthropometric, body composition, and behavioral data were collected at baseline, postintervention (6 months), and follow-up (12 months). Descriptive statistics and mixed models analyses assessed differences between groups over time. Results Mean (± standard deviation) age, and body mass index were 57.5 (± 10.1) years and 36.1 (± 6.2) kg/m2, respectively, and 82% had stage I or II breast cancer. Both groups lost weight. Mean and percentage of weight loss were greater in the guided versus self-guided group (at 6 months: 3.5 kg v 1.3kg; P < .001; 3.6% v 1.4%; P < .001, respectively; at 12 months: 2.7 kg v 1.6 kg; P < .05; 2.6% v 1.6%; P < .05, respectively); 44% in the guided group and 19% in the self-guided group met the 5% goal. Body composition and behavioral changes were also greater in the interventionist-guided group at both time points. Conclusion The study supports the efficacy of a community-based interventionist-guided weight loss program targeting AABCS. Although mean weight loss did not reach the targeted 5%, the mean loss of > 3% at 6 months is associated with improved health outcomes. Affordable, accessible health promotion programs represent a critical resource for AABCS.

Abstract 4482: Effects of lifestyle modification on global DNA methylation in minority breast cancer survivors

2012 ◽  
Author(s):  
Lissette Delgado-Cruzata ◽  
Wenfei Zhang ◽  
Wei Yann Tsai ◽  
Cristina Valdovinos ◽  
Qiao Wang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Dna Methylation ◽  
Cancer Survivors ◽  
Breast Cancer Survivors ◽  
Lifestyle Modification ◽  
Global Dna Methylation

scholarly journals A Pilot Trial of Spirituality Counseling for Weight Loss Maintenance in African American Breast Cancer Survivors

2009 ◽  
Vol 101 (6) ◽  
pp. 552-564 ◽  
Author(s):  
Zora Djuric ◽  
Josephine Mirasolo ◽  
LaVern Kimbrough ◽  
Diane R. Brown ◽  
Lance K. Heilbrun ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Weight Loss ◽  
African American ◽  
Cancer Survivors ◽  
Breast Cancer Survivors ◽  
Pilot Trial ◽  
Weight Loss Maintenance

Patterns of Fitbit Use and Activity Levels Among African American Breast Cancer Survivors During an eHealth Weight Loss Randomized Controlled Trial

2021 ◽  
pp. 089011712110367
Author(s):  
Jeanne M. Ferrante ◽  
Aaron Lulla ◽  
Julie D. Williamson ◽  
Katie A. Devine ◽  
Pamela Ohman-Strickland ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Physical Activity ◽  
Weight Loss ◽  
African American ◽  
Cancer Survivors ◽  
Breast Cancer Survivors ◽  
Activity Levels ◽  
Activity Tracker ◽  
Steps Per Day ◽  
Household Members

Purpose: This study examined adherence with a physical activity tracker and patterns of activity among different subgroups of African American/Black breast cancer survivors (AABCS). Design: Secondary analysis of weight loss trial that used an activity tracker (FitBit) with or without a commercial eHealth program (SparkPeople) over 12 months. Setting and Subjects: AABCS (N = 44) in New Jersey. Measures and Analysis: Adherence with tracker use, steps per day, and active minutes per week were compared by demographic and clinical characteristics using nonparametric statistics. Results: Median adherence was over 6 days per week throughout the 12-months. Adherence was significantly correlated with steps and active minutes (p < 0.015). Groups with lower adherence included: those with 5 or more conditions (p = 0.039), had higher number of household members (p = 0.008), and younger than 60 years (p = 0.044). Median number of steps per day remained consistently around 7000 throughout 12 months. Factors associated with lower activity included: age > 60; retirement; higher number of household members, comorbidity, or baseline BMI; and those in the SparkPeople + Fitbit group. Self-monitoring, goal setting, and self-efficacy were significantly correlated with activity levels (p < 0.05). Conclusion: Use of a physical activity tracker may help increase activity levels in AABCS. Certain subgroups, e.g. those older than age 60 years, retired, with BMI over 40, higher number of comorbidities or more household members, may require additional interventions.

Changes in biomarkers and DNA methylation in breast cancer survivors enrolled in the ENERGY weight loss trial: A pilot study.

2016 ◽  
Vol 34 (3_suppl) ◽  
pp. 181-181
Author(s):  
Wendy Demark-Wahnefried ◽  
Cheryl L Rock ◽  
Rebecca L. Sedjo ◽  
Adetunji Toriola ◽  
Jingxia Liu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Dna Methylation ◽  
Weight Loss ◽  
Pilot Study ◽  
Cancer Survivors ◽  
Breast Cancer Survivors ◽  
Small Sample ◽  
Related Protein ◽  
Intensive Intervention ◽  
Study Results

181 Background: In 2014, an ASPO position statement was released calling for action regarding cancer survivors’ needs for weight management. Reduction of body weight is hypothesized to affect several cancer-related biological pathways. Methods: The Exercise and Nutrition to Enhance Recovery and Good health for You (ENERGY) trial is the largest weight loss trial completed to date among breast cancer survivors. In it, 692 stage Ic-IIIc breast cancer survivors were randomized to an intensive, group-based weight loss intervention with 26 contacts over one year or to a non-intensive intervention with two contacts over the same time period. Results recently reported in JCO showed significantly greater weight loss in the intensive intervention arm compared to the non-intensive arm. A pilot study exploring baseline to 6-month changes in gene methylation and expressed biomarkers was undertaken in 30 chemo-naïve, post-menopausal, non-Hispanic white women who participated in this study. Results: Several significant differences in mean change scores (standard error) between the intensive vs. non-intensive groups were noted, i.e., insulin: -4.19(0.80) vs. 0.42 (1.01)/p = 0.0016; c-peptide: -0.49(0.14) vs. 0.40(0.19)/p = 0.0009; leptin: -15.73(1.79) vs. 2.53(1.78)/p < 0.0001; adiponectin:leptin ratio: 0.67(0.15) vs. 0.010(0.064)/p = 0.0007; homeostasis model of insulin resistance (HOMA-IR): 20.00(4.65) vs. 9.57(5.00)/p = 0.0003; sex hormone binding globulin 20.45(4.61) vs. 8.65(8.00)/p = 0.023; and Follistatin-Related Protein-3 (FSTL3): 0.48(0.19) vs. -0.88(0.55)/p = 0.0497. While effects were in the direction hypothesized for c-reactive protein, interleukin-6, vascular endothelial growth factor, and tumor necrosis factor no significant differences were noted. Significant differences in DNA methylation also were noted for genes encoding for Follistatin Related Protein (corresponds to FSTL3), and those on hormonal/growth pathways (e.g., AMOTL1, ESR, EGR3), inflammatory pathways (e.g., TNFRS10A/TRAIL-R1, C14orf106), and metabolic pathways (e.g., ZBED3, GABRA). Conclusions: While results are based on a small sample and not corrected for multiple testing, they provide evidence that weight loss affects several biomarkers and pathways that impact cancer and which warrant further investigation. Clinical trial information: NCT01112839.

scholarly journals The Effects of a Remote-based Weight Loss Program on Adipocytokines, Metabolic Markers, and Telomere Length in Breast Cancer Survivors: the POWER-Remote Trial

2020 ◽  
Vol 26 (12) ◽  
pp. 3024-3034
Author(s):  
Cesar A. Santa-Maria ◽  
Janelle W. Coughlin ◽  
Dipali Sharma ◽  
Mary Armanios ◽  
Amanda L. Blackford ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Weight Loss ◽  
Cancer Survivors ◽  
Telomere Length ◽  
Breast Cancer Survivors ◽  
Weight Loss Program ◽  
Metabolic Markers
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