Implementing Cognitive Exercises in Electronic Form for Supporting Patients with Alzheimer's Disease

Author(s):  
Agisilaos Chaldogeridis ◽  
Kleopatra Kyropoulou ◽  
Amaryllis-Chryssi Malegiannaki ◽  
Evdokia Nikolaidou ◽  
Thrasyvoulos Tsiatsos

Main goal of this chapter is the development of computerized cognitive exercises for rehabilitation of patients with Alzheimer's disease. More specifically, in traditional rehabilitation settings cognitive exercises are administered by using the paper-and-pencil procedure. This chapter is focused on the transferring of these interventions to an electronic form, enriched with multimedia and interactions that cannot be achieved in the printed form. The presented work tries to automate the procedure and facilitate the psychologist's work. Computer-based intervention programs can exploit all the possibilities of adjusting the difficulty levels of exercise, the speed, the images, using audible signals, accelerating the processing of results for psychologists and much more that add value to creation of such programs. This chapter explores whether and how this kind of exercises can be successfully transferred in an electronic form.

Author(s):  
María Dolores Ruiz-Fernández ◽  
José Manuel Hernández-Padilla ◽  
Rocío Ortiz-Amo ◽  
Cayetano Fernández-Sola ◽  
Isabel María Fernández-Medina ◽  
...  

Caring for a person diagnosed with Alzheimer’s disease has a negative impact on family caregivers’ psychological health. This study examined the factors related to ‘perceived health’ and ‘presence of new-onset mental health problems’ in family caregivers of people diagnosed with mild and moderate Alzheimer’s disease. A cross-sectional observational study carried out in Almeria’s Healthcare District (Spain). A total of 255 family caregivers (42.4% cared for people with mild Alzheimer’s disease and 57.6% cared for people with moderate Alzheimer’s disease) participated in the study from January to December 2015. Mainly, caregivers were women (81.5% in the mild Alzheimer’s disease group and 88.4% in the moderate Alzheimer’s disease group), and their average age was 56.54 years (standard deviation (SD) = 13.13) and 54.47 years (SD = 11.71), respectively. Around 47% of the caregivers had been caring for the person with Alzheimer’s between two and five years. The Goldberg General Health Questionnaire was used to measure perceived health and the presence of new-onset mental health problems. An exploratory descriptive analysis and a multivariate logistic regression analysis were conducted. For caregivers of people with mild Alzheimer’s disease, ‘perceived health’ was related to ‘perceived social support’ (r = −0.21; p = 0.028), ‘person’s level of dependency’ (r = −0.24, p = 0.05), ‘severity of the person’s neuropsychiatric symptoms’ (r = 0.22; p = 0.05), and ‘caregiver’s emotional distress in response to the person’s neuropsychiatric symptoms’ (r = 0.22; p = 0.05). For caregivers of people with moderate Alzheimer’s disease, ‘perceived health’ was related to ‘perceived social support’ (r = −0.31; p ˂ 0.01), ‘presence of neuropsychiatric symptoms’ (r = 0.27, p = 0.01), ‘severity of the person’s neuropsychiatric symptoms’ (r = 0.32, p = 0.01) and ‘caregiver’s emotional distress in response to the person’s neuropsychiatric symptoms’ (r = 0.029; p = 0.01). The presence of new-onset mental health problems was detected in 46.3% (n = 50) of caregivers of people with mild Alzheimer’s and 61.9% (n = 91) of caregivers of people with moderate Alzheimer’s. When people are diagnosed with mild Alzheimer’s disease, intervention programs for caregivers should aim to regulate emotions and promote positive coping strategies. When people are diagnosed with moderate Alzheimer’s disease, intervention programs for caregivers must allow them to adapt to caregiving demands that arise with the progression of Alzheimer’s disease.


Author(s):  
Mohamad El Haj ◽  
Ahmed A Moustafa ◽  
Karim Gallouj ◽  
Philippe Allain

Abstract Objectives We investigated the effect of using smartphone-based calendars (Google and Outlook Calendar) on prospective memory in Alzheimer’s disease (AD). Methods we recruited two groups of participants with mild AD. In one group, prospective memory was cued by a paper-and-pencil calendar, whereas in the second group prospective memory was cued by a smartphone calendar application. After 2 weeks of training to familiarize the participants with calendar use, we invited participants to perform three prospective events per week (e.g., remembering to go to the grocery store) during a 3-week period. Events were cued either by the paper- or smartphone-based calendar. Results we observed fewer omissions of prospective events in the smartphone-based calendar group than in the paper-based calendar group. Conclusions our study suggests positive effects of smartphone calendar applications on prospective memory in AD.


2021 ◽  
Vol 22 (24) ◽  
pp. 13618
Author(s):  
Lernik Hunanyan ◽  
Viktor Ghamaryan ◽  
Ani Makichyan ◽  
Elena Popugaeva

Store-operated calcium entry (SOCE) constitutes a fine-tuning mechanism responsible for the replenishment of intracellular stores. Hippocampal SOCE is regulated by store-operated channels (SOC) organized in tripartite complex TRPC6/ORAI2/STIM2. It is suggested that in neurons, SOCE maintains intracellular homeostatic Ca2+ concentration at resting conditions and is needed to support the structure of dendritic spines. Recent evidence suggests that positive modulators of SOC are prospective drug candidates to treat Alzheimer’s disease (AD) at early stages. Although STIM2 and ORAI2 are definitely involved in the regulation of nSOC amplitude and a play major role in AD pathogenesis, growing evidence suggest that it is not easy to target these proteins pharmacologically. Existing positive modulators of TRPC6 are unsuitable for drug development due to either bad pharmacokinetics or side effects. Thus, we concentrate the review on perspectives to develop specific nSOC modulators based on available 3D structures of TRPC6, ORAI2, and STIM2. We shortly describe the structural features of existing models and the methods used to prepare them. We provide commonly used steps applied for drug design based on 3D structures of target proteins that might be used to develop novel AD preventing therapy.


2007 ◽  
Author(s):  
Stefan Heinzer ◽  
Ralph Müller ◽  
Marco Stampanoni ◽  
Rafael Abela ◽  
Eric P. Meyer ◽  
...  

The Analyst ◽  
2018 ◽  
Vol 143 (24) ◽  
pp. 5959-5964 ◽  
Author(s):  
Maria Paraskevaidi ◽  
Camilo L. M. Morais ◽  
Daniel L. D. Freitas ◽  
Kássio M. G. Lima ◽  
David M. A. Mann ◽  
...  

Plasma samples deposited on low-E slides were analysed in transmission mode by using a FT-NIR spectrometer in order to detect Alzheimer's disease using computer-based methods.


1996 ◽  
Vol 30 (6) ◽  
pp. 493-501 ◽  
Author(s):  
M. Hofmann ◽  
C. Hock ◽  
A. Kühler ◽  
F. Müller-Spahn

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