High Hopes

Author(s):  
Katja Lahikainen ◽  
Timo Pihkala ◽  
Elena Ruskovaara

The regional impact of entrepreneurial universities is a well-researched topic, but less attention is paid to the expectations of the regional policy institutes toward the university. This chapter investigates the regional policy expectations toward the university and what the influence of the university to these expectations is. This study is based on a technological university case in a peripheral region in Finland. The results of the study show that the existence of a single university leads easily to a university-dominant policy and thus to a regional policy lock-in. Consequently, the implementation of the regional policies can be in the hands of the university, leaving other regional stakeholders with a minor role. In order to fully utilize the potential of the university to address the specific regional challenges, the university should not only be seen as a locus of new spin-offs and start-ups, but rather as a producer of qualified graduates and future entrepreneurs.

2021 ◽  
pp. 1-10
Author(s):  
Sina C Stapelfeldt ◽  
Christoph Brandstetter

Abstract Non-synchronous vibrations (NSV) arising near the stall boundary of compressors are a recurring and potentially safety-critical problem in modern axial compressors and fans. Recent research has improved predictive capabilities and physical understanding of NSV but prevention measures are still lacking. This paper addresses this by systematically studying the influence of aerodynamic and structural mistuning on NSV. This is achieved by incorporating mistuning effects in a validated linear model, in which individual blade modes are modelled as single-degree of freedom mass oscillators coupled by a convected aerodynamic disturbance term. The results demonstrate that both structural and aerodynamic mistuning are effective. While structural mistuning improves stability by preventing aero-structure lock-in, aerodynamic mistuning, which locally reduces the tip blockage, attenuates the aerodynamic disturbance causing NSV. In the latter case, the circumferentially-averaged conditions are shown to be most influential, while the pattern plays a minor role. A combination of moderate aerodynamic and structural mistuning (1%) was also found to be effective. These findings are relevant for design decisions, demonstrating that small blade-to-blade variations can suppress NSV.


2021 ◽  
Author(s):  
Sina Stapelfeldt ◽  
Christoph Brandstetter

Abstract Non-synchronous vibrations (NSV) arising near the stall boundary of compressors are a recurring and potentially safety-critical problem in modern axial compressors and fans. Recent research has improved predictive capabilities and physical understanding of NSV but prevention measures are still lacking. This paper addresses this by systematically studying the influence of aerodynamic and structural mistuning on NSV. This is achieved by incorporating mistuning effects in a validated linear model, in which individual blade modes are modelled as single-degree of freedom mass oscillators coupled by a convected aerodynamic disturbance term. The results demonstrate that both structural and aerodynamic mistuning are effective. While structural mistuning improves stability by preventing aero-structure lock-in, aerodynamic mistuning, which locally reduces the tip blockage, attenuates the aerodynamic disturbance causing NSV. In the latter case, the circumferentially-averaged conditions are shown to be most influential, while the pattern plays a minor role. A combination of moderate aerodynamic and structural mistuning (1%) was also found to be effective. These findings are relevant for design decisions, demonstrating that small blade-to-blade variations can suppress NSV.


2016 ◽  
Vol 16 (20) ◽  
pp. 12993-13013 ◽  
Author(s):  
Peter Huszár ◽  
Michal Belda ◽  
Jan Karlický ◽  
Petr Pišoft ◽  
Tomáš Halenka

Abstract. The regional climate model RegCM4.2 was coupled to the chemistry transport model CAMx, including two-way interactions, to evaluate the regional impact of urban emission from central European cities on climate for present-day (2001–2010) and future (2046–2055) periods, and for the future one only emission changes are considered. Short-lived non-CO2 emissions are considered and, for the future impact, only the emission changes are accounted for (the climate is kept “fixed”). The urban impact on climate is calculated with the annihilation approach in which two experiments are performed: one with all emissions included and one without urban emissions. The radiative impacts of non-CO2 primary and secondary formed pollutants are considered, namely ozone (O3), sulfates (PSO4), nitrates (PNO3), primary organic aerosol and primary elementary carbon (POA and PEC).The validation of the modelling system is limited to key climate parameters, near-surface temperature and precipitation. It shows that the model, in general, underestimates temperature and overestimates precipitation. We attribute this behaviour to an excess of cloudiness/water vapour present in the model atmosphere as a consequence of overpredicted evaporation from the surface.The impact on climate is characterised by statistically significant cooling of up to −0.02 and −0.04 K in winter (DJF) and summer (JJA), mainly over cities. We found that the main contributors to the cooling are the direct and indirect effects of the aerosols, while the ozone titration, calculated especially for DJF, plays rather a minor role. In accordance with the vertical extent of the urban-emission-induced aerosol perturbation, cooling dominates the first few model layers up to about 150 m in DJF and 1000 m in JJA. We found a clear diurnal cycle of the radiative impacts with maximum cooling just after noon (JJA) or later in afternoon (DJF). Furthermore, statistically significant decreases of surface radiation are modelled in accordance with the temperature decrease. The impact on the boundary layer height is small but statistically significant and decreases by 1 and 6 m in DJF and JJA respectively. We did not find any statistically significant impact on precipitation and wind speed. Regarding future emissions, the impacts are, in general, smaller as a consequence of smaller emissions, resulting in smaller urban-induced chemical perturbations.In overall, the study suggest that the non-CO2 emissions play rather a minor role in modulating regional climate over central Europe. Much more important is the direct climate impact of urban surfaces via the urban canopy meteorological effects as we showed earlier.


1986 ◽  
Vol 16 (4) ◽  
pp. 822-831 ◽  
Author(s):  
Robert L. Edmonds ◽  
Daniel J. Vogt ◽  
David H. Sandberg ◽  
Charles H. Driver

Decomposition rates of Douglas-fir (Pseudotsugamenziesii (Mirb.) Franco) and red alder (Alnusrubra Bong.) wood (simulating logging residues) were determined in clear-cuttings at the Charles Lathrop Pack Experimental Forest of the University of Washington, which is located approximately 120 km south of Seattle, WA. The influence of diameter (1–2, 4–6, and 8–12 cm), vertical location (buried, on the soil surface, and elevated), season of logging (summer and winter), aspect (north and south), and wood temperature, moisture, and chemistry on wood decomposition rates were determined. Red alder wood decomposed faster (k = 0.035–0.517 year−1) than Douglas-fir wood (k = 0.006–0.205 year−1). In general, buried wood decomposed faster than surface wood, which decomposed faster than elevated wood. Small diameter wood generally decomposed faster than larger diameter wood. Aspect and season of logging had little influence on decomposition rates. Moisture and temperature were the dominant factors related to Douglas-fir wood decomposition, with initial chemistry playing a minor role. Initial wood chemistry, particularly soda solubility, was the dominant factor related to red alder wood decomposition.


2016 ◽  
Author(s):  
Peter Huszár ◽  
Michal Belda ◽  
Jan Karlický ◽  
Petr Pišoft ◽  
Tomáš Halenka

Abstract. The regional climate model RegCM4.2 was coupled to the chemistry transport model CAMx, including two-way interactions, to evaluate the regional impact of urban emission from Central European cities on climate for present (2001–2010) and future (2046–2055). Short-lived non-CO2 emissions are considered, and, for the future impact, only the emission changes are accounted for (the climate is kept 'fixed'). The urban impact on climate is calculated with the annihilation approach, when two experiments are performed: one with all emissions included and one without considering urban emissions. The radiative impacts of non-CO2 primary and secondary formed pollutants are considered: namely ozone (O3), sulfates (PSO4), nitrates (PNO3), primary organic and elementary carbon (POA and PEC). The validation of the modeling system is limited to key climate parameters, near surface and precipitation. It shows that the model, in general, under-estimates temperature and overestimates precipitation. We attribute this behavior to too much cloudiness/water vapor present in the model atmosphere as a consequence of over-predicted evaporation from the surface. The impact on climate is characterized by a statistically significant cooling up to −0.02 K and −0.04 K in winter (DJF) and summer (JJA) season, mainly over cities. We found that the main contributor to the cooling is the aerosols direct and indirect effects, while the ozone titration, calculated especially for DJF, plays rather a minor role. In accordance with the vertical extent of the urban emission induced aerosol perturbation, cooling dominates the first few model layers up to about 150 m in DJF and 1000 m in JJA. We found a clear diurnal cycle of the radiative impacts with maximum cooling just after noon (JJA) or later in afternoon (DJF). Furthermore, statistically significant decreases of surface radiation are modeled, in accordance with the temperature decrease. The impact on the boundary later height is small but statistically significant and reaches −1 m and −6 m decreases in DJF and JJA, respectively. We did not find any statistically significant impact on precipitation and wind speed. Considering future emissions, the impacts are, in general, smaller – as a consequence of smaller emissions resulting in smaller urban induced chemical perturbations. In overall, the study suggest that the non-CO2 emissions play rather a minor role in modulating regional climate over central Europe. Much more important is the direct climate impact of urban surfaces trough urban canopy meteorological effects as we showed earlier.


Author(s):  
Katherine Guérard ◽  
Sébastien Tremblay

In serial memory for spatial information, some studies showed that recall performance suffers when the distance between successive locations increases relatively to the size of the display in which they are presented (the path length effect; e.g., Parmentier et al., 2005) but not when distance is increased by enlarging the size of the display (e.g., Smyth & Scholey, 1994). In the present study, we examined the effect of varying the absolute and relative distance between to-be-remembered items on memory for spatial information. We manipulated path length using small (15″) and large (64″) screens within the same design. In two experiments, we showed that distance was disruptive mainly when it is varied relatively to a fixed reference frame, though increasing the size of the display also had a small deleterious effect on recall. The insertion of a retention interval did not influence these effects, suggesting that rehearsal plays a minor role in mediating the effects of distance on serial spatial memory. We discuss the potential role of perceptual organization in light of the pattern of results.


1958 ◽  
Vol 02 (05/06) ◽  
pp. 462-480 ◽  
Author(s):  
Marc Verstraete ◽  
Patricia A. Clark ◽  
Irving S. Wright

SummaryAn analysis of the results of prothrombin time tests with different types of thromboplastins sheds some light on the problem why the administration of coumarin is difficult to standardize in different centers. Our present ideas on the subject, based on experimental data may be summarized as follows.Several factors of the clotting mechanism are influenced by coumarin derivatives. The action of some of these factors is by-passed in the 1-stage prothrombin time test. The decrease of the prothrombin and factor VII levels may be evaluated in the 1-stage prothrombin time determination (Quick-test). The prolongation of the prothrombin times are, however, predominantly due to the decrease of factor VII activity, the prothrombin content remaining around 50 per cent of normal during an adequate anticoagulant therapy. It is unlikely that this degree of depression of prothrombin is of major significance in interfering with the coagulation mechanism in the protection against thromboembolism. It may, however, play a minor role, which has yet to be evaluated quantitatively. An exact evaluation of factor VII is, therefore, important for the guidance of anticoagulant therapy and the method of choice is the one which is most sensitive to changes in factor VII concentration. The 1-stage prothrombin time test with a rabbit lung thromboplastin seems the most suitable method because rabbit brain preparations exhibit a factor VII-like activity that is not present in rabbit lung preparations.


2016 ◽  
Vol 46 (185) ◽  
pp. 621-638 ◽  
Author(s):  
Christian Siefkes

The ‘Fragment on Machines’ from Marx’s Grundrisse is often cited as an argument that the internal forces of capitalism will lead to its doom. But the argument that the progressive reduction of labor must doom capitalism lacks a proper foundation, as a comparison with the ‘Schemes of Reproduction’ given in Capital II shows. The latter, however, aren’t fully convincing either. In reality, more depends on the private consumption of capitalists than either model recognizes. Ultimately, most can be made of the ‘Fragment on Machines’ by reading it not as an exposure of capitalism’s internal contractions, but as a discussion of a possible communist future where labor (or work) will play but a minor role.


2019 ◽  
Vol 12 (4) ◽  
pp. 311-323 ◽  
Author(s):  
Salvatore Benvenga ◽  
Antonio Micali ◽  
Giovanni Pallio ◽  
Roberto Vita ◽  
Consuelo Malta ◽  
...  

Background: Cadmium (Cd) impairs gametogenesis and damages the blood-testis barrier. Objective: As the primary mechanism of Cd-induced damage is oxidative stress, the effects of two natural antioxidants, myo-inositol (MI) and seleno-L-methionine (Se), were evaluated in mice testes. Methods: Eighty-four male C57 BL/6J mice were divided into twelve groups: 0.9% NaCl (vehicle; 1 ml/kg/day i.p.); Se (0.2 mg/kg/day per os); Se (0.4 mg/kg/day per os); MI (360 mg/kg/day per os); MI plus Se (0.2 mg/kg/day); MI plus Se (0.4 mg/kg/day); CdCl2 (2 mg/kg/day i.p.) plus vehicle; CdCl2 plus MI; CdCl2 plus Se (0.2 mg/kg/day); CdCl2 plus Se (0.4 mg/kg/day); CdCl2 plus MI plus Se (0.2 mg/kg/day); and CdCl2 plus MI plus Se (0.4 mg/kg/day). After 14 days, testes were processed for biochemical, structural and immunohistochemical analyses. Results: CdCl2 increased iNOS and TNF-α expression and Malondialdehyde (MDA) levels, lowered glutathione (GSH) and testosterone, induced testicular lesions, and almost eliminated claudin-11 immunoreactivity. Se administration at 0.2 or 0.4 mg/kg significantly reduced iNOS and TNF-α expression, maintained GSH, MDA and testosterone levels, structural changes and low claudin-11 immunoreactivity. MI alone or associated with Se at 0.2 or 0.4 mg/kg significantly reduced iNOS and TNF-α expression and MDA levels, increased GSH and testosterone levels, ameliorated structural organization and increased claudin-11 patches number. Conclusion: We demonstrated a protective effect of MI, a minor role of Se and an evident positive role of the association between MI and Se on Cd-induced damages of the testis. MI alone or associated with Se might protect testes in subjects exposed to toxicants, at least to those with behavior similar to Cd.


1985 ◽  
Vol 50 (3) ◽  
pp. 581-599 ◽  
Author(s):  
Petr Vaňura ◽  
Emanuel Makrlík

Extraction of microamounts of Sr2+ and Ba2+ (henceforth M2+) from the aqueous solutions of perchloric acid (0.0125-1.02 mol/l) by means of the nitrobenzene solutions of dicarbolide (0.004-0.05 mol/l of H+{Co(C2B9H11)2}-) was studied in the presence of monoglyme (only Ba2+), diglyme, triglyme, and tetraglyme (CH3O-(CH2-CH2O)nCH3, where n = 1, 2, 3, 4). The distribution of glyme betweeen the aqueous and organic phases, the extraction of the protonized glyme molecule HL+ together with the extraction of M2+ ion and of the glyme complex with the M2+ ion, i.e., ML2+ (where L is the molecule of glyme), were found to be the dominating reactions in the systems under study. In the systems with tri- and tetraglymes the extraction of H+ and M2+ ions solvated with two glyme molecules, i.e., the formation of HL2+ and ML22+ species, can probably play a minor role. The values of the respective equilibrium constants, of the stability constants of complexes formed in the organic phase, and the theoretical separation factors αBa/Sr were determined. The effect of the ligand structure on the values of extraction and stability constants in the organic phase is discussed.


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