Deep-Learning-Based Classification and Diagnosis of Alzheimer's Disease

2020 ◽  
pp. 1358-1382
Author(s):  
Rekh Ram Janghel

Alzheimer's is the most common form of dementia in India and it is one of the leading causes of death in the world. Currently it is diagnosed by calculating the MSME score and by manual study of MRI scan. In this chapter, the authors develop and compare different methods to diagnose and predict Alzheimer's disease by processing structural magnetic resonance image scans (MRI scans) with deep learning neural networks. The authors implement one model of deep-learning networks which are convolution neural network (CNN). They use four different architectures of CNN, namely Lenet-5, AlexNet, ZFNet, and R-CNN architecture. The best accuracies for 75-25 cross validation and 90-10 cross validation are 97.68% and 98.75%, respectively, and achieved by ZFNet architecture of convolution neural network. This research will help in further studies on improving the accuracy of Alzheimer's diagnosis and prediction using neural networks.


Author(s):  
Rekh Ram Janghel

Alzheimer's is the most common form of dementia in India and it is one of the leading causes of death in the world. Currently it is diagnosed by calculating the MSME score and by manual study of MRI scan. In this chapter, the authors develop and compare different methods to diagnose and predict Alzheimer's disease by processing structural magnetic resonance image scans (MRI scans) with deep learning neural networks. The authors implement one model of deep-learning networks which are convolution neural network (CNN). They use four different architectures of CNN, namely Lenet-5, AlexNet, ZFNet, and R-CNN architecture. The best accuracies for 75-25 cross validation and 90-10 cross validation are 97.68% and 98.75%, respectively, and achieved by ZFNet architecture of convolution neural network. This research will help in further studies on improving the accuracy of Alzheimer's diagnosis and prediction using neural networks.



Author(s):  
Yanteng Zhang ◽  
Qizhi Teng ◽  
Linbo Qing ◽  
Yan Liu ◽  
Xiaohai He

Alzheimer’s disease (AD) is a degenerative brain disease and the most common cause of dementia. In recent years, with the widespread application of artificial intelligence in the medical field, various deep learning-based methods have been applied for AD detection using sMRI images. Many of these networks achieved AD vs HC (Healthy Control) classification accuracy of up to 90%but with a large number of computational parameters and floating point operations (FLOPs). In this paper, we adopt a novel ghost module, which uses a series of cheap operations of linear transformation to generate more feature maps, embedded into our designed ResNet architecture for task of AD vs HC classification. According to experiments on the OASIS dataset, our lightweight network achieves an optimistic accuracy of 97.92%and its total parameters are dozens of times smaller than state-of-the-art deep learning networks. Our proposed AD classification network achieves better performance while the computational cost is reduced significantly.



2021 ◽  
pp. 1-17
Author(s):  
Hania H. Farag ◽  
Lamiaa A. A. Said ◽  
Mohamed R. M. Rizk ◽  
Magdy Abd ElAzim Ahmed

COVID-19 has been considered as a global pandemic. Recently, researchers are using deep learning networks for medical diseases’ diagnosis. Some of these researches focuses on optimizing deep learning neural networks for enhancing the network accuracy. Optimizing the Convolutional Neural Network includes testing various networks which are obtained through manually configuring their hyperparameters, then the configuration with the highest accuracy is implemented. Each time a different database is used, a different combination of the hyperparameters is required. This paper introduces two COVID-19 diagnosing systems using both Residual Network and Xception Network optimized by random search in the purpose of finding optimal models that give better diagnosis rates for COVID-19. The proposed systems showed that hyperparameters tuning for the ResNet and the Xception Net using random search optimization give more accurate results than other techniques with accuracies 99.27536% and 100 % respectively. We can conclude that hyperparameters tuning using random search optimization for either the tuned Residual Network or the tuned Xception Network gives better accuracies than other techniques diagnosing COVID-19.



2021 ◽  
Author(s):  
Ghassan Mohammed Halawani

The main purpose of this project is to modify a convolutional neural network for image classification, based on a deep-learning framework. A transfer learning technique is used by the MATLAB interface to Alex-Net to train and modify the parameters in the last two fully connected layers of Alex-Net with a new dataset to perform classifications of thousands of images. First, the general common architecture of most neural networks and their benefits are presented. The mathematical models and the role of each part in the neural network are explained in detail. Second, different neural networks are studied in terms of architecture, application, and the working method to highlight the strengths and weaknesses of each of neural network. The final part conducts a detailed study on one of the most powerful deep-learning networks in image classification – i.e. the convolutional neural network – and how it can be modified to suit different classification tasks by using transfer learning technique in MATLAB.



2021 ◽  
Vol 8 (2) ◽  
pp. 48-57
Author(s):  
Deepthi Kamath ◽  
Misba Firdose Fathima ◽  
Monica K. P ◽  
Kusuma Mohanchandra

Alzheimer's disease is an extremely popular cause of dementia which leads to memory loss, problem-solving and other thinking abilities that are severe enough to interfere with daily life. Detection of Alzheimer’s at a prior stage is crucial as it can prevent significant damage to the patient’s brain. In this paper, a method to detect Alzheimer’s  Disease from Brain MRI images is proposed. The proposed approach extracts shape features and texture of the Hippocampus region from the MRI scans and a Neural Network is used as a Multi-Class Classifier for detection of AD. The proposed approach is implemented and it gives better accuracy as compared to conventional approaches. In this paper, Convolutional Neural Network is the Neural Network approach used for the detection of AD at a prodromal stage.





IBRO Reports ◽  
2019 ◽  
Vol 6 ◽  
pp. S452
Author(s):  
Cheol-Bin Park ◽  
Hyunsu Jeong ◽  
Kyu Yeong Choi ◽  
Byeong C. Kim ◽  
Jang Jae Lee ◽  
...  


2021 ◽  
Vol 2021 ◽  
pp. 1-16
Author(s):  
Monika Sethi ◽  
Sachin Ahuja ◽  
Shalli Rani ◽  
Puneet Bawa ◽  
Atef Zaguia

Alzheimer’s disease (AD) is one of the most important causes of mortality in elderly people, and it is often challenging to use traditional manual procedures when diagnosing a disease in the early stages. The successful implementation of machine learning (ML) techniques has also shown their effectiveness and its reliability as one of the better options for an early diagnosis of AD. But the heterogeneous dimensions and composition of the disease data have undoubtedly made diagnostics more difficult, needing a sufficient model choice to overcome the difficulty. Therefore, in this paper, four different 2D and 3D convolutional neural network (CNN) frameworks based on Bayesian search optimization are proposed to develop an optimized deep learning model to predict the early onset of AD binary and ternary classification on magnetic resonance imaging (MRI) scans. Moreover, certain hyperparameters such as learning rate, optimizers, and hidden units are to be set and adjusted for the performance boosting of the deep learning model. Bayesian optimization enables to leverage advantage throughout the experiments: A persistent hyperparameter space testing provides not only the output but also about the nearest conclusions. In this way, the series of experiments needed to explore space can be substantially reduced. Finally, alongside the use of Bayesian approaches, long short-term memory (LSTM) through the process of augmentation has resulted in finding the better settings of the model that too in less iterations with an relative improvement (RI) of 7.03%, 12.19%, 10.80%, and 11.99% over the four systems optimized with manual hyperparameters tuning such that hyperparameters that look more appealing from past data as well as the conventional techniques of manual selection.



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