Investigations on Impact of Blasting in Tunnels

Blasting with longer advance per round leaves an impact both visible (in the form of overbreak) and invisible (cracks) in the surrounding rockmass, however, a number of controlled-blasting techniques, that is line drilling, pre-splitting, and smooth blasting, have been developed to minimise this problem. These techniques require additional drilling, controlled charging, and detonation, and thus, are not preferred in regular development activities. Investigations have been carried out in five different horizontal development drivages of metal mines to assess the blasting impact using burn cut and arrive at the blast-induced rock damage (BIRD) model. Vibration monitoring close to the blast was carried out using accelerometers for the first time in India to develop vibration predictors and overbreak threshold levels for individual sites. This paper reports the development of the overbreak predictive model (BIRD) for burn cut blasting in hard rock drivages by combining the relevant rock, blast design, and explosive parameters. A multivariate statistical model has been developed and validated and the same can find ready application in tunnels and mines for exercising suitable engineering controls both in blast design and explosive selection for reduced basting impacts.

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VALIDATING A MULTIVARIATE STATISTICAL MODEL USED TO ASSESS IF FORMATION BRINES ARE THE MOST PROBABLE SOURCE OF HIGH SALINITY IN SHALLOW GROUNDWATER

10.1130/abs/2016am-285543 ◽

2016 ◽

Author(s):

Nathaniel Patrick Chien ◽

◽

Laura K. Lautz

Keyword(s):

Statistical Model ◽

High Salinity ◽

Shallow Groundwater ◽

Multivariate Statistical ◽

Probable Source ◽

Multivariate Statistical Model

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A single-round selection of selective DNA aptamers for mammalian cells by polymer-enhanced capillary transient isotachophoresis

The Analyst ◽

10.1039/c7an00909g ◽

2017 ◽

Vol 142 (21) ◽

pp. 4030-4038 ◽

Cited By ~ 12

Author(s):

Kazuki Hirose ◽

Maho Tsuchida ◽

Hinako Asakura ◽

Koji Wakui ◽

Keitaro Yoshimoto ◽

...

Keyword(s):

Capillary Electrophoresis ◽

Mammalian Cells ◽

Dna Aptamer ◽

Dna Aptamers ◽

Aptamer Selection ◽

Selection For ◽

First Time ◽

Selection Of

A single-round DNA aptamer selection for mammalian cells was successfully achieved for the first time using a capillary electrophoresis (CE)-based methodology.

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Response of Cisplatin Resistant Skov-3 Cells to [Pt(O,O′-Acac)(γ-Acac)(DMS)] Treatment Revealed by a Metabolomic 1H-NMR Study

Molecules ◽

10.3390/molecules23092301 ◽

2018 ◽

Vol 23 (9) ◽

pp. 2301 ◽

Cited By ~ 12

Author(s):

Federica De Castro ◽

Michele Benedetti ◽

Giovanna Antonaci ◽

Laura Del Coco ◽

Sandra De Pascali ◽

...

Keyword(s):

Ovarian Carcinoma ◽

1H Nmr ◽

Mechanism Of Action ◽

Culture Media ◽

Epithelial Ovarian Carcinoma ◽

Multivariate Statistical ◽

Nmr Study ◽

First Time

The novel [Pt(O,O′-acac)(γ-acac)(DMS)], Ptac2S, Pt(II) complex has recently gained increasing attention as a potential anticancer agent for its pharmacological activity shown in different tumor cell lines, studied both in vitro and in vivo. The mechanism of action of Ptac2S, operating on non-genomic targets, is known to be very different from that of cis-[PtCl2(NH3)2], cisplatin, targeting nucleic acids. In this work, we evaluated the cytotoxicity of Ptac2S on the cisplatin resistant Epithelial Ovarian Carcinoma (EOC), SKOV-3 cells, by the MTT assay. A 1H-NMR metabolomic approach coupled with multivariate statistical analysis was used for the first time for Ptac2S to figure out the biological mechanisms of action of the complex. The metabolic variations of intracellular metabolites and the composition of the corresponding extracellular culture media were compared to those of cisplatin (cells were treated at the IC50 doses of both drugs). The reported comparative metabolomic analysis revealed a very different metabolic profile between Ptac2S and cisplatin treated samples, thus confirming the different mechanism of action of Ptac2S also in the Epithelial Ovarian Carcinoma (EOC), SKOV-3 cells line. In particular, higher levels of pyruvate were observed in Ptac2S treated, with respect to cisplatin treated, cells (in both aqueous and culture media). In addition, a very different lipid expression resulted after the exposure to the two drugs (Ptac2S and cisplatin). These results suggest a possible explanation for the Ptac2S ability to circumvent cisplatin resistance in SKOV-3 cells.

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144 The Epidemiology of Hoof-related Lameness in Western Canadian Feedlot Cattle

Journal of Animal Science ◽

10.1093/jas/skab235.147 ◽

2021 ◽

Vol 99 (Supplement_3) ◽

pp. 81-82

Author(s):

Sarah E Erickson ◽

Murray Jelinski ◽

Karen S Schwartzkopf-Genswein ◽

Calvin Booker ◽

Eugene Janzen

Keyword(s):

North Carolina ◽

Total Population ◽

Health Management ◽

Statistical Significance ◽

Feedlot Cattle ◽

Foot Rot ◽

Digital Dermatitis ◽

Multivariate Statistical ◽

Multivariate Statistical Model ◽

Control And Prevention

Abstract The epidemiology of hoof-related lameness (HRL) in western Canadian feedlots, with a focus on digital dermatitis (DD), was described and analyzed to help inform recommendations on lameness control and prevention in western Canadian feedlot cattle. The retrospective data in this study were accessed from 28 western Canadian feedlots that placed cattle in 2014–2018, inclusive. The total population for this study was 1,796,176 cattle, with an annual placement average of 12,830 cattle per feedlot. These data were accessed through iFHMS Consolidated Database, provided by Feedlot Health Management Services by TELUS Agriculture, and manipulated using Microsoft® Office Access 365 ProPlus and Microsoft® Office Excel 365 ProPlus. Epidemiological analyses determined that lameness accounts for 25.7% of all treatments in western Canadian feedlots. Of those treatments, 71.7% are localized to the hoof, corresponding to 18.6% of all treatments. The most common HRL diseases are infectious bovine pododermatitis [foot rot (FR)]; digital dermatitis (DD), also known as hairy-heel wart or strawberry foot rot; and toe-tip necrosis syndrome (TTNS). These diseases account for 89.6%, 7.9% and 2.4% of HRL, respectively. Between 2014 and 2018, HRL prevalence ranged between 1.93% and 3.09% of the population, with FR consistently having the highest prevalence and TTNS the lowest. HRL and DD were tested for their associations with several animal-level risk factors using © Ausvet 2021 Epitools software. The resultant crude, univariate odds ratio values, evaluated at 95% confidence, are summarized in Table 1. Based on this analysis, acquisition source has the largest influence on the odds of developing HRL and DD, followed by population size, and placement quarter. Using SAS® (Version 9.4, SAS Institute Inc, Cary, North Carolina) statistical software, these preliminary findings will be subjected to a multivariate statistical model, which will provide adjusted OR values and statistical significance for the data in this study.

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