Surface Morphology Variations of Porous Nano-Calcium Phosphate/Poly(L-Lactic Acid) Composites in PBS

Using poly-L-lactic acid for implantable biodegradable scaffold has potential biocompatibility issue due to its acidic degradation byproducts. We have previously reported that the addition of amorphous calcium phosphate improved poly-L-lactic acid coating biocompatibility. In the present study, poly-L-lactic acid and poly-L-lactic acid/amorphous calcium phosphate scaffolds were implanted in pig coronary arteries for 28 days. At the follow-up angiographic evaluation, no case of stent thrombosis was observed, and the arteries that were stented with the copolymer scaffold had significantly less inflammation and nuclear factor-κB expression and a greater degree of reendothelialization. The serum levels of vascular endothelial growth factor and nitric oxide, as well the expression of endothelial nitric oxide synthase and platelet-endothelial cell adhesion molecule-1, were also significantly higher. In conclusion, the addition of amorphous calcium phosphate to biodegradable poly-L-lactic acid scaffold minimizes the inflammatory response, promotes the growth of endothelial cells, and accelerates the reendothelialization of the stented coronary arteries.

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Serum Calcium, Phosphate, Fluoride and Lactic Acid in Dental Caries

Journal of Medical Sciences(Faisalabad) ◽

10.3923/jms.2006.193.197 ◽

2006 ◽

Vol 6 (2) ◽

pp. 193-197 ◽

Cited By ~ 2

Author(s):

M. Jawed ◽

Syed M. Shahid . ◽

Z. Islam .

Keyword(s):

Lactic Acid ◽

Calcium Phosphate ◽

Dental Caries ◽

Serum Calcium

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Magnetron Sputtering Deposition of Calcium Phosphate Films with Nanoscale Grain Morphology in their Surface

MRS Proceedings ◽

10.1557/proc-975-0975-dd06-08 ◽

2006 ◽

Vol 975 ◽

Author(s):

Wilfredo Otaño ◽

Víctor M. Pantojas ◽

Juan M. Figueroa ◽

Darimar Hernández ◽

Alejandro Rodríguez-Navarro

Keyword(s):

Calcium Phosphate ◽

Surface Morphology ◽

Magnetron Sputtering ◽

Deposition Time ◽

Grain Morphology ◽

Average Diameter ◽

Deposition Process ◽

Medical Implants ◽

Sputtering Deposition ◽

Coated Implant

ABSTRACTHydroxyapatite (HA) is a calcium phosphate mineral analogous to the mineral part of bone. This similarity makes this material bioactive and suitable to coat medical implants. However, at present, there is not a coating technique which gives the coated implant the desired properties and long life required for medical implants.In an effort to produce HA coatings with improved properties, calcium phosphate films were prepared using magnetron sputtering deposition on a silicon substrate at 600°C. Initial efforts resulted in the deposition of amorphous films with a distinctive grain-like surface morphology. The morphological grain size was studied using SEM and found that it was possible to control the average diameter value of the round shaped grains by adjusting the deposition time. Increasing the deposition time increases the mean grain diameter. EDS spectra showed the unintentional addition of carbon, iron and nickel to the samples during deposition. After eliminating the impurities, it was possible to prepare calcium phosphate films in the HA phase but without the grain-like surface morphology. These results suggested that the impurities prevented the formation of the calcium phosphate HA phase while acting as nuclei for the heterogeneous nucleation of the grains. This is an important result where the deposition process parameters can be controlled to functionalize the films in order to produce distinctive nanoscale features in the surface morphology.

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Macroporous biphasic calcium phosphate scaffolds reinforced by poly-L-lactic acid/hydroxyapatite nanocomposite coatings for bone regeneration

Biochemical Engineering Journal ◽

10.1016/j.bej.2015.02.026 ◽

2015 ◽

Vol 98 ◽

pp. 29-37 ◽

Cited By ~ 43

Author(s):

Lei Nie ◽

Dong Chen ◽

Jun Fu ◽

Shuhua Yang ◽

Ruixia Hou ◽

...

Keyword(s):

Lactic Acid ◽

Calcium Phosphate ◽

Bone Regeneration ◽

Biphasic Calcium Phosphate ◽

Nanocomposite Coatings

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A Case of Fahr's Disease Presenting as Chorea Successfully Treated by the Use of Quetiapine

Clinical Medicine Case Reports ◽

10.4137/ccrep.s3423 ◽

2009 ◽

Vol 2 ◽

pp. CCRep.S3423

Author(s):

Syoichiro Kono ◽

Yasuhiro Manabe ◽

Tomotaka Tanaka ◽

Daiki Fujii ◽

Yasuko Sakai ◽

...

Keyword(s):

Computed Tomography ◽

Cerebrospinal Fluid ◽

Lactic Acid ◽

White Matter ◽

Calcium Phosphate ◽

Subcortical White Matter ◽

Laboratory Studies ◽

Brain Computed Tomography ◽

Fahr’S Disease ◽

Fahr's Disease

We report a case of 30-year-old man presenting chorea in his legs. A brain computed tomography (CT) scan showed bilateral symmetric calcifications in the basal ganglia, thalamus, cerebellum and subcortical white matter. Laboratory studies showed no abnormalities of serum calcium, phosphate, PTH, lactic acid, pyruvic acid and cerebrospinal fluid. Under the diagnosis of Fahr's disease (FD), we treated with quetiapine (75 mg/day), which completely abolished his symptoms and he showed no other side effect. Our experience suggests that quetiapine is well tolerated in FD patients and effectively treats chorea without extrapyramidal movement.

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