Poly(ε-Caprolactone)-b-Hyperbranched Polyglycidol for Targeted Drug Delivery

A bolock copolymer of poly(ε-caprolactone) and hyperbranched polyglycidol (PCL-b-HPG) was synthezed by “living” copolymerization of ε-caprolactone (CL) and glycidol. The chemical structure was confirmed by 1H NMR, IR and GPC spectrum. Nanoparticles (NPs) of 50–100 nm were formulated from the PCL-b-HPG copolymer with no evidence of particles aggregation as determined by TEM. RGD peptide was covalently coupled on the end hydroxyl groups that could enable recepter–mediated recongnation onto targeted tissues. In conclusion, a hyperbranched copolymer PCL-b-HPG was synthezed by a novel and simple approach. The numerous functional end-groups could facilitate the attachment of biomolecules for further investigation as targeted drug delivery.