Gene Polymorphism and Susceptibility to Brucellosis

Polymorphisms in the regulatory regions of cytokine genes can affect the level of cytokine production, and may be associated with predisposition to infectious diseases. Some reports suggest that the cytokine gene polymorphisms can contribute to the susceptibility to brucellosis. The aim of this review is to find out any probable association of genetic polymorphisms of interleukin gene, transforming growth factor gene, tumor necrosis factor gene and other genes with brucellosis in terms of susceptibility to the disease or occurrence of focal complications. The study of this review finds that the inheritance of the above-mentioned gene polymorphisms and alleles are considered conferring susceptibility to brucellosis, and this review would provide the basis for further research and development about susceptibility to brucellosis.