The Effects of Dechlorane Plus on Toxicity

2013 ◽  
Vol 380-384 ◽  
pp. 4163-4166 ◽  
Author(s):  
Zhong Ying Wu ◽  
Lei Huang ◽  
Ying Long Gao ◽  
Qing Hao Guo ◽  
Ye Qing Sun
Keyword(s):  
Oxidative Stress ◽  
Flame Retardant ◽  
Mouse Liver ◽  
Potential Toxicity ◽  
Dechlorane Plus ◽  
Inflammatory Infiltration ◽  
Toxicity Effect ◽  
And Oxidative Stress

Dechlorane plus (DP) is a world-widely used flame retardant detected in the environment, biota and humans. The potential toxicity effect of DP is not well studied. In this research, mice were fed with DP-containing food. After two weeks, histopathological observation and oxidative stress was investigated in mouse liver. Our results demonstrated that over-dose DP induced inflammatory infiltration, hepatocellular swelling and oxidative stress in the mouse liver.

scholarly journals Comparative Effects of Phosphoenolpyruvate, a Glycolytic Intermediate, as an Organ Preservation Agent with Glucose and N-Acetylcysteine against Organ Damage during Cold Storage of Mouse Liver and Kidney

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Yoichi Ishitsuka ◽  
Yusuke Fukumoto ◽  
Yuki Kondo ◽  
Mitsuru Irikura ◽  
Daisuke Kadowaki ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Organ Preservation ◽  
Mouse Liver ◽  
Organ Damage ◽  
Histological Changes ◽  
Glycolytic Intermediate ◽  
Cold Preservation ◽  
Oxidative Stress Parameters ◽  
Liver And Kidney ◽  
And Oxidative Stress

We evaluated the usefulness of phosphoenolpyruvate (PEP), a glycolytic intermediate with antioxidative and energy supplementation potentials, as an organ preservation agent. Using ex vivo mouse liver and kidney of a static cold storage model, we compared the effects of PEP against organ damage and oxidative stress during cold preservation with those of glucose or N-acetylcysteine (NAC). Lactate dehydrogenase (LDH) leakage, histological changes, and oxidative stress parameters (measured as thiobarbituric acid reactive substance and glutathione content) were determined. PEP (100 mM) significantly prevented an increase in LDH leakage, histological changes, such as tubulonecrosis and vacuolization, and changes in oxidative stress parameters during 72 h of cold preservation in mouse liver. Although glucose (100 mM) partly prevented LDH leakage and histological changes, no effects against oxidative stress were observed. By contrast, NAC inhibited oxidative stress in the liver and did not prevent LDH leakage or histological changes. PEP also significantly prevented kidney damage during cold preservation in a dose-dependent manner, and the protective effects were superior to those of glucose and NAC. We suggest that PEP, a functional carbohydrate with organ protective and antioxidative activities, may be useful as an organ preservation agent in clinical transplantation.

Taurine deficiency induces hyperammonemia and oxidative stress and senescence in mouse liver

2018 ◽  
Vol 56 (01) ◽  
pp. E2-E89
Author(s):  
N Qvartskhava ◽  
C Jin ◽  
T Buschmann ◽  
N Monhasery ◽  
J Oenarto ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Mouse Liver ◽  
Taurine Deficiency ◽  
And Oxidative Stress

scholarly journals WY-14,643–Induced Cell Proliferation and Oxidative Stress in Mouse Liver are Independent of NADPH Oxidase

2007 ◽  
Vol 98 (2) ◽  
pp. 366-374 ◽  
Author(s):  
Courtney G. Woods ◽  
Amanda M. Burns ◽  
Blair U. Bradford ◽  
Pamela K. Ross ◽  
Oksana Kosyk ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cell Proliferation ◽  
Nadph Oxidase ◽  
Mouse Liver ◽  
And Oxidative Stress

Sa1555 Protective Role of 4-Phenyl Butyric Acid Treatment on Acetaminophen-Induced ER Stress and Oxidative Stress in Mouse Liver

2016 ◽  
Vol 150 (4) ◽  
pp. S1065
Author(s):  
Kazuyoshi Kon ◽  
Hiromi Kusama ◽  
Kenichi Ikejima ◽  
Kumiko Arai ◽  
Tomonori Aoyama ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Er Stress ◽  
Butyric Acid ◽  
Mouse Liver ◽  
Acid Treatment ◽  
Protective Role ◽  
And Oxidative Stress

Effect of Every Other Day Feeding on Mitochondrial Free Radical Production and Oxidative Stress in Mouse Liver

2008 ◽  
Vol 11 (3) ◽  
pp. 621-629 ◽  
Author(s):  
Pilar Caro ◽  
José Gómez ◽  
Mónica López-Torres ◽  
Inés Sánchez ◽  
Alba Naudi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Free Radical ◽  
Mouse Liver ◽  
Free Radical Production ◽  
Radical Production ◽  
And Oxidative Stress
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