Preparation and Characterization of Hydrophobic Silica Zirconium Nanoparticles

2014 ◽  
Vol 625 ◽  
pp. 503-508
Author(s):  
Tayseir M. Abd Ellateif ◽  
Saikat Mitra ◽  
T. Murugesan ◽  
Khairun Azizi Azizli
Keyword(s):  
Weight Gain ◽  
Silica Nanoparticles ◽  
Zirconium Oxide ◽  
Particle Distribution ◽  
Hydrophobic Silica ◽  
Pure Silica ◽  
Bet Analysis ◽  
Unmodified Silica ◽  
Silica Sols

Hydrophobic silica nanoparticles were synthesized by silica sols modified with different percentage of zirconium sol using liquid modification. The hydrophobicity test demonstrated that silica zirconium nanoparticles are more hydrophobic as they showed 1% to 5% weight gain compared to 8% for pure silica nanoparticles. The synthesized silica nanoparticles were characterized using different techniques to investigate the effect of zirconium modification on silica nanoparticles characteristics. Structure and composition of unmodified silica nanoparticles and modified one were studied using FTIR; the results showed that the zirconium oxide was anchored to the surface of silica nanoparticles. TEM and BET analysis showed that the percentage of zirconium added to silica had distinct effect on the particle distribution and surface area of silica nanoparticles.

Preparation of Polymer Microspheres Using Silane Coupling Agent Modified Nano-SiO2 as Single Stabilizer

2011 ◽  
Vol 341-342 ◽  
pp. 247-251 ◽  
Author(s):  
Guang Hui Ma ◽  
Fa Ai Zhang ◽  
Chang Sheng Gu
Keyword(s):  
Silica Nanoparticles ◽  
Average Particle Size ◽  
Optical Microscope ◽  
Coupling Agents ◽  
Average Particle ◽  
Silane Coupling Agents ◽  
Pickering Emulsion Polymerization ◽  
Silane Coupling ◽  
Unmodified Silica

This paper demonstrates that silica nanoparticles were modified by the four silane coupling agents (KH-151, KH-550, KH-560, KH-570) firstly, then polystyrene/silica (PS/SiO2) composite microsphere with PS core and silica nanoparticles shell were prepared by Pickering emulsion polymerization. The characterization of optical microscope (OM), scanning electron microscope (SEM), and thermogravimetic analysis ( TGA) illustrates that these microsphere are composed of PS and silica nanoparticles. Silica nanoparticles modified by the different silane coupling agents could form the stable PS/SiO2 microsphere over 70 °C, while the unmodified silica nanoparticles are difficult to form stable PS/SiO2 microspheres at the same temperature. The PS/KH-151-SiO2 microsphere exhibits the least average particle size, while the PS/KH-570-SiO2 microsphere produces the largest. Both SEM and TGA confirm that microsphere surface exists solid nanoparticles.

Synthesis and Characterization of Ibandronate-Loaded Silica Nanoparticles and Collagen Nanocomposites

2015 ◽  
Vol 16 (7) ◽  
pp. 661-667 ◽  
Author(s):  
Gisela Alvarez ◽  
Maria Echazu ◽  
Christian Olivetti ◽  
Martin Desimone
Keyword(s):  
Silica Nanoparticles ◽  
Synthesis And Characterization

scholarly journals Synthesis and Characterization of Hydrophobic Silica Thin Layer Derived from Methyltrimethoxysilane (MTMS)

2018 ◽  
Vol 299 ◽  
pp. 012041 ◽  
Author(s):  
Adi Darmawan ◽  
Riyadini Utari ◽  
Riza Eka Saputra ◽  
Suhartana ◽  
Yayuk Astuti
Keyword(s):  
Thin Layer ◽  
Synthesis And Characterization ◽  
Hydrophobic Silica

scholarly journals Different Effects of the Immunomodulatory Drug GMDP Immobilized onto Aminopropyl Modified and Unmodified Mesoporous Silica Nanoparticles upon Peritoneal Macrophages of Women with Endometriosis

2013 ◽  
Vol 2013 ◽  
pp. 1-10 ◽  
Author(s):  
Yuliya Antsiferova ◽  
Nataliya Sotnikova ◽  
Elena Parfenyuk
Keyword(s):  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Topical Delivery ◽  
Peritoneal Macrophages ◽  
Scavenger Receptors ◽  
Membrane Expression ◽  
Unmodified Silica ◽  
Immunomodulatory Drug ◽  
High Level

The aim of the present work was to compare in vitro the possibility of application of unmodified silica nanoparticles (UMNPs) and modified by aminopropyl groups silica nanoparticles (AMNPs) for topical delivery of immunomodulatory drug GMDP to the peritoneal macrophages of women with endometriosis. The absence of cytotoxic effect and high cellular uptake was demonstrated for both types of silica nanoparticles. The immobilization of GMDP on the UMNPs led to the suppression of the stimulatory effect of GMDP on the membrane expression of scavenger receptors SR-AI and SR-B, mRNAs expression of NOD2 and RAGE, and synthesis of proteolytic enzyme MMP-9 and its inhibitor TIMP-1. GMDP, immobilized onto AMNPs, enhanced the initially reduced membrane expression of SRs and increased NOD2, RAGE, and MMP-9 mRNAs expression by macrophages. Simultaneously high level of mRNAs expression of factors, preventing undesirable hyperactivation of peritoneal macrophages (SOCS1 and TIMP-1), was observed in macrophages incubated in the presence of GMDP, immobilized onto AMNPs. The effect of AMNPs immobilized GMDP in some cases exceeded the effect of free GMDP. Thus, among the studied types of silica nanoparticles, AMNPs are the most suitable nanoparticles for topical delivery of GMDP to the peritoneal macrophages.

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