Intercalation of Fenoprofen into Layered Double Hydroxide for the Formation of Controlled Release Anti-Inflammatory Drug

2017 ◽  
Vol 1142 ◽  
pp. 230-233 ◽  
Author(s):  
Siti Halimah Sarijo ◽  
Monica Limau Jadam ◽  
Faizah Md Saleh
Keyword(s):  
Controlled Release ◽  
Organic Compound ◽  
Layered Double Hydroxide ◽  
Self Assembly ◽  
Interlayer Spacing ◽  
Nanocomposite Materials ◽  
Molar Ratio ◽  
Hybrid Nanocomposite ◽  
Assembly Method ◽  
Double Hydroxide

Synthesis of a new hybrid nanocomposite materials, zinc-aluminium-fenoprofen, ZAF was successfully accomplished by self-assembly method with molar ratio of Zn to Al; R=2 at concentration of fenoprofen=0.3 M. As a result of the successful intercalation, the interlayer spacing expanded from 9.8 Å in the zinc-aluminium-layered double hydroxide, ZAL to 20.1 Å in the ZAF hybrid nanocomposite. The FTIR spectra of the ZAF show resemblance peaks of ZAL and fenoprofen indicating the inclusion of the organic compound into the LDH interlamellae. The percentage loading of the guest anion, fenoprofen in ZAL was estimated to be about 63.4% (w/w) calculated from the carbon content.

Synthesis, Characterization and Sustained Release Properties of Zinc-Aluminium-9-Hydroxy-9-Flourenecarboxylate Nanocomposite

2011 ◽  
Vol 422 ◽  
pp. 102-106 ◽  
Author(s):  
Siti Halimah Sarijo ◽  
A Ahmad ◽  
Z. Jubri
Keyword(s):  
Sustained Release ◽  
Layered Double Hydroxide ◽  
Self Assembly ◽  
Plant Growth Regulator ◽  
Sodium Phosphate ◽  
Molar Ratio ◽  
Basal Spacing ◽  
Hybrid Nanocomposite ◽  
Assembly Method ◽  
Double Hydroxide

Zn-Al-9-hydroxy-9-flourenecarboxylate-layered double hydroxide, ZAF nanocomposite was successfully synthesized by direct self-assembly method with Zn to Al molar ratio, R = 4 and 0.4 M 9-hydroxy-9-flourenecarboxylate, 9H9F. Due to the inclusion of a new anion, 9H9F basal spacing expanded from 8.9 Å in the Zn-Al-layered double hydroxide, ZAL to 13.2 Å in the ZAF. The FTIR spectra of the hybrid nanocomposite show resemblance peaks of the ZAL and 9H9F indicating the inclusion of the organic compound into the LDH interlamellae. The percentage loading of 9H9F was found to be 75.9 % (w/w). Sustained release of 9H9F from ZAF into various aqueous solutions was found to be dependent on the incoming anion, with the percentage saturated release of 94%, 72%, and 15% in sodium phosphate, sodium sulfate and sodium chloride aqueous solution 0.0005 M, respectively. This study indicates that ZAL can be used as a host carrier for plant growth regulator, 9H9F with sustained release capability.

The Effect of Zinc to Aluminium Molar Ratio on the Physico-Chemical Properties of Zinc-Aluminium-3,4-Dichlorophenoxy Acetate Nanocomposite

2013 ◽  
Vol 756 ◽  
pp. 127-134
Author(s):  
Sheikh Ahmad Izaddin Sheikh Mohd Ghazali ◽  
Mohd Zobir Hussein ◽  
Siti Halimah Sarijo
Keyword(s):  
Layered Double Hydroxide ◽  
Mole Fraction ◽  
Self Assembly ◽  
Chemical Properties ◽  
Zinc Ion ◽  
Molar Ratio ◽  
Basal Spacing ◽  
Molar Ratios ◽  
Assembly Method ◽  
Double Hydroxide

Layered double hydroxide (LDH) hybrid materials of Zn-Al-layered double hydroxide-3,4-dichlorophenoxy acetate acidnanocomposites (ZADs) were prepared by direct self-assembly method. The pH of the solution was adjusted to 7.5 using 2M NaOH. Various Zn2+ to Al3+ molar ratios, R ranging from 1 to 6 were used with a fixed concentration of 3,4-D at 0.3 M. The Powder X-ray diffraction (PXRD) patterns showed the formation of well-ordered nanocomposite with the expansion of basal spacing from 8.9 Å in the Zinc-Aluminium-Layered Double Hydroxide (ZAL) to 18.7 - 22.1 Å in the resulting nanocomposites. The Fourier transform infrared (FTIR)spectra for the nanocomposites showed features for both ZAL and ZAD, showing the successful intercalation of the organic moiety into the LDH interlayer. The percentage loading of 3,4-dichlorophenoxy acetati acid(3,4-D) in LDH was found to be increased from 34.7-48.1 % (w/w), as the mole fraction of Al decreased from 0.44-0.15. This study shows that the mole fraction of zinc ion was replaced by aluminium ion in the LDH plays an important role in controlling the physic-chemical properties of the resulting material.

Synthesis and Physicochemical Characterization of Mg-Al-Flufenamate-Layered Double Hydroxide

2017 ◽  
Vol 887 ◽  
pp. 100-103
Author(s):  
Siti Halimah Sarijo ◽  
Monica Limau Jadam ◽  
Z. Jubri
Keyword(s):  
Organic Compound ◽  
Layered Double Hydroxide ◽  
Self Assembly ◽  
Physicochemical Characterization ◽  
Flufenamic Acid ◽  
Basal Spacing ◽  
Hybrid Nanocomposite ◽  
Assembly Technique ◽  
Double Hydroxide

A nonsteroidal drug, flufenamic acid (FA) was successfully intercalated into magnesium-aluminium-layered double hydroxide, MAL for the formation of magnesium-aluminium-flufenamate-layered double hydroxide, MAF by self-assembly technique. As a result of the successful intercalation, basal spacing increased from 9.8 Å in the MAL to 23.5 Å in the MAF hybrid nanocomposite. The FTIR spectra of the MAF hybrid nanocomposite show resemblance peaks of the MAL and FA suggesting the inclusion of the organic compound into the MAL interlamellae. The percentage loading of FA was found to be 74.4 % (w/w) calculated from the percentage of carbon in the resulting material, MAF.

scholarly journals Removal of Eriochrome Black T DYE from Aqueous Solution by Nickel/Aluminium Layered Double Hydroxide

2019 ◽  
Vol 1 (3) ◽  
pp. 79-86
Author(s):  
Nurdiyana Roslan ◽  
Mazidah Mamat ◽  
Ku Halim Ku Bulat
Keyword(s):  
Aqueous Solution ◽  
Layered Double Hydroxide ◽  
Self Assembly ◽  
Freundlich Isotherm ◽  
Thermogravimetric Analyzer ◽  
Eriochrome Black T ◽  
Dye Pollutants ◽  
Assembly Method ◽  
Infrared Spectrophotometer ◽  
Double Hydroxide

Batik industry is well known in the East Coast of Malaysia, particularly in Terengganu and Kelantan. This industry consumes a lot of water for the batik making process which contributes to high discharge of wastewater containing excess dye pollutants. Hence, in this study, an anionic clay of nickel/aluminium-layered double hydroxide (NiAL) was investigated as a potential adsorbent for the removal of anionic dye of Eriochrome Black T (EBT). The NiAL was synthesized via self-assembly method and characterization of NiAL was carried out using powder X-ray diffraction (PXRD) and Fourier transform infrared spectrophotometer (FTIR). The composition and morphology of NiAL was further analyzed using carbon, hydrogen, nitrogen, sulphur elemental analyzer (CHNS), thermogravimetric analyzer (TGA) and scanning electron microscope (SEM). The potential of NiAL as an adsorbent for the removal of EBT in aqueous solution was tested at different dosages of NiAL. The adsorption ability was analyzed by using two common adsorption isotherms, which were Langmuir and Freundlich models. The adsorption of EBT onto NiAL was governed by Freundlich isotherm model indicating that the adsorption occurs in heterogeneous system.

Hierarchical coated metal hydroxide nanoconstructs as potential controlled release carriers of photosensitizer for skin melanoma

RSC Advances ◽  
2015 ◽  
Vol 5 (53) ◽  
pp. 42666-42680 ◽  
Author(s):  
Ranjith Kumar Kankala ◽  
Yaswanth Kuthati ◽  
Chen-Lun Liu ◽  
Chia-Hung Lee
Keyword(s):  
Controlled Release ◽  
Layered Double Hydroxide ◽  
Metal Hydroxide ◽  
Skin Melanoma ◽  
Anionic Clay ◽  
Coated Metal ◽  
Clay Matrix ◽  
Double Hydroxide

Inorganic nanostructured ensembles containing an anionic clay matrix with layered double hydroxide (LDH) were designed in nanooncology for photosensitizer delivery.

Preparation of Sodium Paeonolsilate Intercalated into Layered Double Hydroxides and its Release Properties

2015 ◽  
Vol 1095 ◽  
pp. 349-354 ◽  
Author(s):  
Liang Hua Gu ◽  
Hong Qing Song ◽  
Zhi Yong Sun ◽  
Ji Yong Zheng ◽  
Jin Wei Zhang ◽  
...  
Keyword(s):  
Controlled Release ◽  
Release Kinetics ◽  
Molar Ratio ◽  
Burst Release ◽  
X Ray Diffraction ◽  
Release Process ◽  
Rate Determining Step ◽  
Release Ratio ◽  
Double Hydroxide ◽  
Double Hydroxides

A controlled release composite has been prepared by intercalation of sodium paeonolsilate (PAS) into Mg/Al layered double hydroxide (LDH) with the molar ratio (M2+/M3+) of 2:1. The powder X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FT-IR) confirm the intercalation of PAS into the galleries of LDH. The chemical composites of PAS-LDH were revealed by elemental analysis. Release tests of the PAS-LDH composite showed that no burst release phenomenon occurred at the beginning stage and a high release ratio of PAS (89.8%) was obtained, exhibiting controlled release behavior. Furthermore, the parabolic diffusion model was used to simulate the release kinetics of PAS from the LDH carrier, indicating that the intraparticle diffusion via ion-exchange is the rate-determining step in the release process. It is significance in this work for introducing the PAS-LDH composite to develop antifouling materials with long-term activity.

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