The Effect of Zinc to Aluminium Molar Ratio on the Physico-Chemical Properties of Zinc-Aluminium-3,4-Dichlorophenoxy Acetate Nanocomposite

2013 ◽  
Vol 756 ◽  
pp. 127-134
Author(s):  
Sheikh Ahmad Izaddin Sheikh Mohd Ghazali ◽  
Mohd Zobir Hussein ◽  
Siti Halimah Sarijo
Keyword(s):  
Layered Double Hydroxide ◽  
Mole Fraction ◽  
Self Assembly ◽  
Chemical Properties ◽  
Zinc Ion ◽  
Molar Ratio ◽  
Basal Spacing ◽  
Molar Ratios ◽  
Assembly Method ◽  
Double Hydroxide

Layered double hydroxide (LDH) hybrid materials of Zn-Al-layered double hydroxide-3,4-dichlorophenoxy acetate acidnanocomposites (ZADs) were prepared by direct self-assembly method. The pH of the solution was adjusted to 7.5 using 2M NaOH. Various Zn2+ to Al3+ molar ratios, R ranging from 1 to 6 were used with a fixed concentration of 3,4-D at 0.3 M. The Powder X-ray diffraction (PXRD) patterns showed the formation of well-ordered nanocomposite with the expansion of basal spacing from 8.9 Å in the Zinc-Aluminium-Layered Double Hydroxide (ZAL) to 18.7 - 22.1 Å in the resulting nanocomposites. The Fourier transform infrared (FTIR)spectra for the nanocomposites showed features for both ZAL and ZAD, showing the successful intercalation of the organic moiety into the LDH interlayer. The percentage loading of 3,4-dichlorophenoxy acetati acid(3,4-D) in LDH was found to be increased from 34.7-48.1 % (w/w), as the mole fraction of Al decreased from 0.44-0.15. This study shows that the mole fraction of zinc ion was replaced by aluminium ion in the LDH plays an important role in controlling the physic-chemical properties of the resulting material.

Synthesis, Characterization and Sustained Release Properties of Zinc-Aluminium-9-Hydroxy-9-Flourenecarboxylate Nanocomposite

2011 ◽  
Vol 422 ◽  
pp. 102-106 ◽  
Author(s):  
Siti Halimah Sarijo ◽  
A Ahmad ◽  
Z. Jubri
Keyword(s):  
Sustained Release ◽  
Layered Double Hydroxide ◽  
Self Assembly ◽  
Plant Growth Regulator ◽  
Sodium Phosphate ◽  
Molar Ratio ◽  
Basal Spacing ◽  
Hybrid Nanocomposite ◽  
Assembly Method ◽  
Double Hydroxide

Zn-Al-9-hydroxy-9-flourenecarboxylate-layered double hydroxide, ZAF nanocomposite was successfully synthesized by direct self-assembly method with Zn to Al molar ratio, R = 4 and 0.4 M 9-hydroxy-9-flourenecarboxylate, 9H9F. Due to the inclusion of a new anion, 9H9F basal spacing expanded from 8.9 Å in the Zn-Al-layered double hydroxide, ZAL to 13.2 Å in the ZAF. The FTIR spectra of the hybrid nanocomposite show resemblance peaks of the ZAL and 9H9F indicating the inclusion of the organic compound into the LDH interlamellae. The percentage loading of 9H9F was found to be 75.9 % (w/w). Sustained release of 9H9F from ZAF into various aqueous solutions was found to be dependent on the incoming anion, with the percentage saturated release of 94%, 72%, and 15% in sodium phosphate, sodium sulfate and sodium chloride aqueous solution 0.0005 M, respectively. This study indicates that ZAL can be used as a host carrier for plant growth regulator, 9H9F with sustained release capability.

Intercalation of Fenoprofen into Layered Double Hydroxide for the Formation of Controlled Release Anti-Inflammatory Drug

2017 ◽  
Vol 1142 ◽  
pp. 230-233 ◽  
Author(s):  
Siti Halimah Sarijo ◽  
Monica Limau Jadam ◽  
Faizah Md Saleh
Keyword(s):  
Controlled Release ◽  
Organic Compound ◽  
Layered Double Hydroxide ◽  
Self Assembly ◽  
Interlayer Spacing ◽  
Nanocomposite Materials ◽  
Molar Ratio ◽  
Hybrid Nanocomposite ◽  
Assembly Method ◽  
Double Hydroxide

Synthesis of a new hybrid nanocomposite materials, zinc-aluminium-fenoprofen, ZAF was successfully accomplished by self-assembly method with molar ratio of Zn to Al; R=2 at concentration of fenoprofen=0.3 M. As a result of the successful intercalation, the interlayer spacing expanded from 9.8 Å in the zinc-aluminium-layered double hydroxide, ZAL to 20.1 Å in the ZAF hybrid nanocomposite. The FTIR spectra of the ZAF show resemblance peaks of ZAL and fenoprofen indicating the inclusion of the organic compound into the LDH interlamellae. The percentage loading of the guest anion, fenoprofen in ZAL was estimated to be about 63.4% (w/w) calculated from the carbon content.

scholarly journals Synthesis of organo-mineral nanohybrid material: Phenoxyacetate anions in the lamella of Mg-Al-layered double hydroxide

2006 ◽  
Vol 12 (4) ◽  
pp. 225-230
Author(s):  
Botomei Anca ◽  
Emil Dumitriu ◽  
Hulea Vasile ◽  
Nastro Alfonso
Keyword(s):  
Layered Double Hydroxide ◽  
Self Assembly ◽  
Basal Spacing ◽  
Phenoxyacetic Acid ◽  
Absorption Bands ◽  
Characteristic Functional ◽  
Reconstruction Methods ◽  
Assembly Technique ◽  
Double Hydroxide ◽  
Nanohybrid Material

An organo-mineral nanohybrid material in which the organic moiety is interleaved inside the inorganic lamella was prepared by using phenoxyacetate anions as a guest in the Mg-Al-layered double hydroxide lamella (as an inorganic host) by the self-assembly technique, anion exchange and the reconstruction methods. The powder XRD patterns of the resulted materials show that the basal spacing of the Mg-AI-layered double hydroxide with carbonate as the counter anions expanded from 7.7 ? to around 16.6 ? in the nanohybrid materials. IR studies show that the absorption bands of the resulting materials correspond to the characteristic functional groups of the host and the guest structures. When the two results are taken together, the expansion can be attributed to the intercalation of the phenoxyacetic acid in the inorganic interlamella for the formation of the nanohybrid material. The intercalation of phenoxyacetate anions was also confirmed by thermogravimetric analysis (TG).

scholarly journals Synthesis and characterization of two-dimensional (2D) nanosheet zinc aluminum layered double hydroxide (Zn/Al LDH) via an alkali-free route

2021 ◽  
Vol 15 (1) ◽  
pp. 82
Author(s):  
Rabiatul Adawiyah Mohd Agus ◽  
Siti Khatijah Deraman ◽  
Nazrizawati A. Tajuddin
Keyword(s):  
Layered Double Hydroxide ◽  
Nitrate Solution ◽  
Zinc Nitrate ◽  
Molar Ratio ◽  
Molar Ratios ◽  
Sem Image ◽  
Constant Ph ◽  
Xrd Patterns ◽  
Double Hydroxide

The effect of different molar ratios on the synthesis of zinc aluminium layered double hydroxide (Zn/Al LDH) via an alkali-free route was carried out in this research. This method was prepared by mixing zinc nitrate solution, aluminium nitrate solution, and ammonium carbonate solution at a constant pH of 8.5 with a spanning ratio of Zn to Al from 4:1, 3:1, and 2:1. The XRD patterns showed crystal nanostructure of Zn/Al LDHs was successfully formed. The lattice parameters (a and c) were slightly increased with the increasing of Zn/Al molar ratio. A larger hexagonal platelet is observed in the SEM image align with the high molar ratio of Zn/Al synthesized. The same trend has been observed in the FTIR spectra.   Keywords: Zn/Al LDH, alkali-free route, different molar ratio, XRD, SEM, FTIR

scholarly journals Synthesis and Application of Magnetic@layered Double Hydroxide as an Anti-Inflammatory Drugs Nanocarrier

2020 ◽  
Author(s):  
Vahid Yousefi ◽  
Vahideh Tarhriz ◽  
Shirin Eyvazi ◽  
Azita Dilmaghani
Keyword(s):  
Layered Double Hydroxide ◽  
Water Solubility ◽  
Chemical Properties ◽  
Basal Spacing ◽  
Magnetic Nanospheres ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Double Hydroxide ◽  
Physical And Chemical

Abstract Background: Magnetic nanocomposites with a core-shell nanostructure have huge applications in different sciences especially in the release of the drugs, because of their exclusive physical and chemical properties. In this research, magnetic@layered double hydroxide multicore@shell nanostructure was synthesized by the facile experiment and is used as novel drug nanocarrier.Methods: Magnetic nanospheres were synthesized by a facile one-step solvothermal route, and then, layered double hydroxide nanoflakes were prepared on the magnetic nanospheres by coprecipitation experiment. The synthesized nanostructures were characterized by FTIR, XRD, SEM, VSM, and TEM, respectively. After intercalation with Ibuprofen and Diclofenac as anti-inflammatory drugs and using exchange anion experiment, the basal spacing of synthesized layered double hydroxides was compared with brucite nanosheets from 0.48 nm to 2.62 nm and 2.22 nm, respectively. Results: The results indicated that Ibuprofen and Diclofenac were successfully intercalated into the interlay space of LDHs via bridging bidentate interaction. In addition, in-vitro drug release experiments in pH 7.4, phosphate-buffered saline (abbreviated PBS) showed constant release profiles with Ibuprofen and Diclofenac as model drugs with different lipophilicity, water solubility, size, and steric effect. Conclusion: The Fe3O4@LDH-ibuprofen and Fe3O4@LDH-diclofenac had the advantage of the strong interaction between the carboxyl groups with higher trivalent cations by bridging bidentate, clarity, and high thermal stability. It is confirmed that Fe3O4@LDH multicore-shell nanostructure may have potential application for constant drug delivery.

scholarly journals Synthesis and Application of Magnetic@Layered Double Hydroxide Multicore-Shell Nanostructure as a Novel Anti-Inflammatory Drugs Nanocarrier

2020 ◽  
Author(s):  
Vahid Yousefi ◽  
Vahideh Tarhriz ◽  
Shirin Eyvazi ◽  
Azita Dilmaghani
Keyword(s):  
Layered Double Hydroxide ◽  
Water Solubility ◽  
Chemical Properties ◽  
Basal Spacing ◽  
Magnetic Nanospheres ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Double Hydroxide ◽  
Physical And Chemical

Abstract Background: magnetic nanocomposites with a core-shell nanostructure has huge applications in different sciences especially in the release of the drugs, because of their exclusive physical and chemical properties. In this research, magnetic@layered double hydroxide multicore@shell nanostructure was synthesized by the facile experimentand is used as novel drug nanocarrier.Methods: Magnetic nanospheres were synthesized by a facile one-step solvothermal route, and in following, layered double hydroxide nanoflakes were prepared on the magnetic nanospheres by coprecipitation experiment. The synthesized nanostructures were characterized by FTIR, XRD, SEM, VSM and TEM, respectively. After intercalation with Ibuprofen and Diclofenac as the anti-inflammatory drugs by using exchange anion experiment, the basal spacing of synthesized layered double hydroxides were compared with brucite nanosheets from 0.48 nm to 2.62 nm and 2.22 nm, respectively. Results: The results indicated Ibuprofen and Diclofenac were successfully intercalated into the interlay space of LDHs by bridging bidentate interaction. Besides, in vitro drug release experiments in pH 7.4, Phosphate-buffered saline (abbreviated PBS) showed the constant release profiles with Ibuprofen and diclofenac as model drugs with different lipophilicity and water solubility and size and steric effect. Conclusions: The Fe3O4@LDH-ibuprofen and Fe3O4@LDH-diclofenac had the advantage of the strong interaction between the carboxyl groups with higher trivalent cations by bridging bidentate, clarity and high thermal stability. We confirm, which Fe3O4@LDH multicore-shell nanostructure will have potential application for constant drug delivery.

scholarly journals Synthesis and application of magnetic@layered double hydroxide as an anti-inflammatory drugs nanocarrier

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Vahid Yousefi ◽  
Vahideh Tarhriz ◽  
Shirin Eyvazi ◽  
Azita Dilmaghani
Keyword(s):  
Layered Double Hydroxide ◽  
Water Solubility ◽  
Chemical Properties ◽  
Basal Spacing ◽  
Magnetic Nanospheres ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Double Hydroxide ◽  
Physical And Chemical

Abstract Background Magnetic nanocomposites with a core–shell nanostructure have huge applications in different sciences especially in the release of the drugs, because of their exclusive physical and chemical properties. In this research, magnetic@layered double hydroxide multicore@shell nanostructure was synthesized by the facile experiment and is used as novel drug nanocarrier. Methods Magnetic nanospheres were synthesized by a facile one-step solvothermal route, and then, layered double hydroxide nanoflakes were prepared on the magnetic nanospheres by coprecipitation experiment. The synthesized nanostructures were characterized by FTIR, XRD, SEM, VSM, and TEM, respectively. After intercalation with Ibuprofen and Diclofenac as anti-inflammatory drugs and using exchange anion experiment, the basal spacing of synthesized layered double hydroxides was compared with brucite nanosheets from 0.48 nm to 2.62 nm and 2.22 nm, respectively. Results The results indicated that Ibuprofen and Diclofenac were successfully intercalated into the interlay space of LDHs via bridging bidentate interaction. In addition, in-vitro drug release experiments in pH 7.4, phosphate-buffered saline (PBS) showed constant release profiles with Ibuprofen and Diclofenac as model drugs with different lipophilicity, water solubility, size, and steric effect. Conclusion The Fe3O4@LDH-ibuprofen and Fe3O4@LDH-diclofenac had the advantage of the strong interaction between the carboxyl groups with higher trivalent cations by bridging bidentate, clarity, and high thermal stability. It is confirmed that Fe3O4@LDH multicore-shell nanostructure may have potential application for constant drug delivery.

Synthesis of Calcium/Aluminium-Ciprofloxacin-Layered Double Hydroxide for a New Antibacterial Drug Formulation

2021 ◽  
Vol 317 ◽  
pp. 233-238
Author(s):  
Monica Limau Jadam ◽  
Zaemah Jubri ◽  
Siti Halimah Sarijo
Keyword(s):  
Layered Double Hydroxide ◽  
Drug Formulation ◽  
Molar Ratio ◽  
Basal Spacing ◽  
Antibacterial Drug ◽  
X Ray Diffraction ◽  
Exchange Method ◽  
Prospective Application ◽  
Double Hydroxide ◽  
Novel Drug

An antibacterial drug, ciprofloxacin (Cipro) was successfully encapsulated into Ca/Al-layered double hydroxide (CLDH) with molar ratio Ca/Al = 3:1 (R3) by anion exchange method at optimum concentration of 0.2 M Cipro. The successful intercalation was confirmed by patterns analysis of powder X-ray diffraction (PXRD), Fourier transform infrared spectroscopy (FTIR), elemental analysis (CHNS) and accelerated surface area and porosity (ASAP) analysis. Basal spacing of CLDH synthesized in this study is 8.7 Å. Due to the inclusion of Cipro into the layered CLDH, basal spacing expanded to 16.2 Å in Ca/Al-Cipro-LDH (CCLDH) compare to in CLDH. The FTIR spectra of the hybrid nanocomposite show resemblance peaks of the layered double hydroxide (LDH) and Cipro, indicating the inclusion of the drug anion into the LDH interlamellae. The percentage loading of Cipro calculated from the data obtained from CHNS is 75.9% (w/w). This shows that Ca/Al-layered double hydroxide, CLDH has prospective application as the host for ciprofloxacin (1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid), an antibacterial drug for a novel drug delivery formulation.

Synthesis and Physicochemical Characterization of Mg-Al-Flufenamate-Layered Double Hydroxide

2017 ◽  
Vol 887 ◽  
pp. 100-103
Author(s):  
Siti Halimah Sarijo ◽  
Monica Limau Jadam ◽  
Z. Jubri
Keyword(s):  
Organic Compound ◽  
Layered Double Hydroxide ◽  
Self Assembly ◽  
Physicochemical Characterization ◽  
Flufenamic Acid ◽  
Basal Spacing ◽  
Hybrid Nanocomposite ◽  
Assembly Technique ◽  
Double Hydroxide

A nonsteroidal drug, flufenamic acid (FA) was successfully intercalated into magnesium-aluminium-layered double hydroxide, MAL for the formation of magnesium-aluminium-flufenamate-layered double hydroxide, MAF by self-assembly technique. As a result of the successful intercalation, basal spacing increased from 9.8 Å in the MAL to 23.5 Å in the MAF hybrid nanocomposite. The FTIR spectra of the MAF hybrid nanocomposite show resemblance peaks of the MAL and FA suggesting the inclusion of the organic compound into the MAL interlamellae. The percentage loading of FA was found to be 74.4 % (w/w) calculated from the percentage of carbon in the resulting material, MAF.

Sign in / Sign up

Export Citation Format

Share Document