Preparation and Structure Characterization of Poly(lactide-co-ethylene carbonate) Microspheres

2013 ◽  
Vol 706-708 ◽  
pp. 215-218
Author(s):  
Chun Sheng Cheng ◽  
Ji Yi Yang ◽  
Yu Yue Qin ◽  
Jian Fan ◽  
Tian Rui Zhao ◽  
...  
Keyword(s):  
Encapsulation Efficiency ◽  
Drug Loading ◽  
Ethylene Carbonate ◽  
Structure Characterization ◽  
Biodegradable Microspheres ◽  
The Novel ◽  
Solvent Evaporation Method ◽  
Spherical Surfaces ◽  
Internal Structures

The purpose of this study was to prepare and characterize tinidazole-loaded poly (lactide-co-ethylene carbonate) (PLEC) microspheres. These biodegradable microspheres were prepared by solvent evaporation method. The effect of selected emulsifier, polymer type, and ratio of tinidazole to PLEC were investigated. An aqueous gelatin solution used as emulsifier resulted in uniform microspheres with spherical surfaces. The PLEC microspheres exhibited rough surface and porous internal structures when compared with the PLA microspheres. The ratio of tinidazole to PLEC (1/10) exhibited higher encapsulation efficiency and drug loading of tinidazole. The introduction of hydrophilic PEC content influenced the structure and encapsulation efficiency of microspheres. These results suggest that the novel PLEC microspheres can be useful for drug delivery systems.

scholarly journals SYNTHESIS, CRYSTAL STRUCTURE, HIRSHFELD SURFACE ANALYSIS AND QUANTUM CHEMICAL CALCULATIONS OF [Cu2(C6H9N3S)2(ClO4)2] π-COMPLEX WITH 2-ALLYLAMINO-5-METHYL-1,3,4-THIADIAZOLE

2021 ◽  
Vol 26 (1(77)) ◽  
pp. 16-25
Author(s):  
Yu. I. Slyvka ◽  
E. A. Goreshnik ◽  
N. T. Pokhodylo ◽  
М. G. Mys’kiv
Keyword(s):  
Crystal Structure ◽  
Computational Analysis ◽  
Structure Characterization ◽  
Electrochemical Technique ◽  
The Novel ◽  
X Ray Diffraction ◽  
X Ray ◽  
Π Complex ◽  
Centrosymmetric Dimers

This work is focused on the synthesis and structure characterization of the novel Cu(I) π-complex [Cu2(Thiaz1)2(ClO4)2] (1) with 2-allylamino-5-methyl-1,3,4-thiadiazole (Thiaz1) ligand. The crystals of the compound were obtained by means of the alternating-current electrochemical technique and studied using single crystal X-ray diffraction. The crystal structure of the complex 1 is constructed from the centrosymmetric dimers, in which two copper(I) ions are coordinated by two Thiaz1 molecules through thiadiazole N atoms and allylic C=C bond. Energy framework computational analysis for structure 1 has been performed.  

Murine Ortholog of the Novel Glycosyltransferase, B3GTL: Primary Structure, Characterization of the Gene and Transcripts, and Expression in Tissues

2006 ◽  
Vol 25 (8) ◽  
pp. 465-474 ◽  
Author(s):  
Taisto Y.K. Heinonen ◽  
Markku Pelto-Huikko ◽  
Leena Pasternack ◽  
Markku Mäki ◽  
Heikki Kainulainen
Keyword(s):  
Primary Structure ◽  
Structure Characterization ◽  
The Novel

Preparation and Characterization of Folate-Targeted Chitosan Nanoparticles Loaded with Hydroxycamptothecin

2012 ◽  
Vol 557-559 ◽  
pp. 434-437
Author(s):  
Yi Xiao Wang ◽  
Zhen Qing Hou ◽  
Fei Cui ◽  
Li Hua Shen ◽  
Li Ya Xie ◽  
...  
Keyword(s):  
Encapsulation Efficiency ◽  
Loading Rate ◽  
Chitosan Nanoparticles ◽  
Burst Release ◽  
The Novel ◽  
Targeting Therapy ◽  
X Ray ◽  
Biphasic Pattern ◽  
Selective Targeting

FA-targeted and 10-hydroxycamptothecin loaded chitosan nanoparticles (FA-HCPT-NPs) were prepared with a combination of emulsion-solvent evaporation and chemical crosslink method. The analysis revealed that the FA-HCPT-NPs were spherical with diameter of 255.5  16.2 nm, zeta potential of + 70 mV, HCPT encapsulation efficiency of 81.2% and loading rate of 2.5%. X-ray powder diffraction illustrated that HCPT was buried as an amorphous form in the NPs. The release profiles of HCPT exhibited a biphasic pattern characterized by an initial burst release followed by a slower and sustained release. The results indicated that the novel FA-HCPT-NPs could be a potential drug delivery system for tumor cell-selective targeting therapy.

Development and Characterization of Core–Shell Nanoparticles for Anticancer Therapy

2018 ◽  
Vol 24 (8) ◽  
pp. 5768-5777
Author(s):  
G. N. K Ganesh ◽  
Vianni Chopra ◽  
Veera Venkata Satyanarayana Reddy Karri ◽  
S. Kiran Koundinya ◽  
R. Suresh Kumar ◽  
...  
Keyword(s):  
Encapsulation Efficiency ◽  
Cytidine Deaminase ◽  
Drug Loading ◽  
Double Emulsion ◽  
Core Shell ◽  
Small Cell Lung ◽  
Shell Nanoparticles ◽  
Core Shell Nanoparticles ◽  
Body Clearance

Gemcitabine hydrophilic used for the treatment of solid tumours like ovarian, breast, bladder and small-cell lung cancer, pancreatic cancer. In year 1996 FDA approved it for breast cancer treatment but it has a drawback of rapid body clearance by kidney and metabolism by the plasmatic enzyme cytidine-deaminase. The aim of the study is to entrap gemcitabine in Core–Shell nanoparticles which acts an efficient carrier system for increasing drug’s efficacy. Gemcitabine loaded with BSA-PLGA core shell Nanoparticle prepared by double emulsion-solvent diffusion evaporation method using a ratio optimized to 1:4 respectively. The particle size was found to be 237.6 nm and high encapsulation efficiency was achieved with a concentration of 1.5% TPGS as a primary stabilizer and 3% PVA as a secondary stabilizer. The drug loading and encapsulation efficiency of the Nanoparticles was 18 μg/mg and 35.1% w/w. IC-50 value of the formulation was found to be (10 μM) in MIA-PaCA 2 cell line.

Design, Fabrication and Characterization of Nanoliposomes Containing Snake Venom of Pseudocereaster percius

2022 ◽  
Vol 02 ◽  
Author(s):  
Tara Emami ◽  
Ali Nazari Shirvan ◽  
Mahmoudreza Jaafari ◽  
Rasool Madani ◽  
Fariba Golchinfar ◽  
...  
Keyword(s):  
Snake Venom ◽  
Active Site ◽  
Encapsulation Efficiency ◽  
Solvent Evaporation Method ◽  
Phospholipase Activity ◽  
Liposomal Formulations ◽  
Significant Harm ◽  
Fabrication And Characterization ◽  
Large Animals

Background: Development of antivenom or antidote requires the repetition of immunization of large animals, such as horses and goats, which ultimately releases the IgG immunoglobulin produced in the serum specimen. As snake venom involves a variety of proteins and enzymes getting administered into the animal, this process can inflict significant harm to the animal, therefore choosing carriers that can deliver the least amount of venom could be a safer option for animal immunization Objective: In this research, nanoliposomes were used to encapsulate venom as a protected cargo for immunization. We used two distinct liposomal formulations to entrap the venom: 1,2-distearoyl-sn-glycero-3-phosphocholine, 1,2-distearoyl-sn-glycero-3-phospho-(1′-rac-glycerol) associated with cholesterol in one formulation and dimethyldioctadecylamonium (Bromide salt) paired with cholesterol in the other. Method: Liposomal formulations prepared by solvent evaporation method and the venom was encapsulated in liposomes and evaluated for size and zeta potential. Meanwhile, encapsulation efficiency, venom release percentage, and phospholipase activity have all been analyzed. Results: The findings revealed that dimethyldioctadecylamonium (Bromide salt) combined with cholesterol had the highest encapsulation efficiency. In this formulation, the venom release rate had a steady-state profile. The lack of phospholipase activity in this formulation may be due to a bromide group in the liposomal structure that could be useful for immunization. Conclusion: Liposomal formulations, which do not have the active site of the snake venom enzymes, could be used for venom encapsulation.

scholarly journals 3-(3,5-Difluorophenyl)-1-phenyl-1H-pyrazole-4-carbaldehyde

2018 ◽  
Author(s):  
Naveen Kumar ◽  
Swamy Sreenivasa ◽  
Vasantha Kumar ◽  
Nadigar Revansiddappa Mohan
Keyword(s):  
Spectral Analysis ◽  
13C Nmr ◽  
Title Compound ◽  
Structure Characterization ◽  
Dimethyl Formamide ◽  
The Novel ◽  
Mass Spectral Analysis ◽  
Mass Spectral ◽  
Phosphorous Oxychloride

Vilsmeier–Haack reaction of (E)-1-(1-(3,5-difluorophenyl)ethylidene)-2-phenylhydrazine (1) using dimethyl formamide in excess of phosphorous oxychloride by conventional method, resulted in the synthesis of title compound 3-(3,5-difluorophenyl)-1-phenyl-1H-pyrazole-4- carbaldehyde (2) in good yield and high purity. Structure characterization of the novel title compound was done by IR, 1H NMR, 13C NMR and mass spectral analysis.

Characterization of microwave-sintered ceramic composites

1993 ◽  
Vol 51 ◽  
pp. 1136-1137
Author(s):  
X. Zhang ◽  
Y. Pan ◽  
T.T. Meek
Keyword(s):  
Matrix Material ◽  
Maximum Output Power ◽  
Ceramic Matrix Composite ◽  
Ceramic Composites ◽  
Processing Technique ◽  
Structure Characterization ◽  
Alumina Powder ◽  
Maximum Output ◽  
Sintered Ceramic

Industrial microwave heating technology has emerged as a new ceramic processing technique. The unique advantages of fast sintering, high density, and improved materials properties makes it superior in certain respects to other processing methods. This work presents the structure characterization of a microwave sintered ceramic matrix composite.Commercial α-alumina powder A-16 (Alcoa) is chosen as the matrix material, β-silicon carbide whiskers (Third Millennium Technologies, Inc.) are used as the reinforcing element. The green samples consisted of 90 vol% Al2O3 powder and 10 vol% ultrasonically-dispersed SiC whiskers. The powder mixture is blended together, and then uniaxially pressed into a cylindrical pellet under a pressure of 230 MPa, which yields a 52% green density. The sintering experiments are carried out using an industry microwave system (Gober, Model S6F) which generates microwave radiation at 2.45 GHz with a maximum output power of 6 kW. The composites are sintered at two different temperatures (1550°C and 1650°C) with various isothermal processing time intervals ranging from 10 to 20 min.

Glibenclamide-Nicotinamide Cocrystals Synthesized by The Solvent Evaporation Method to Enhance Solubility and Dissolution Rate of Glibenclamide

2019 ◽  
Vol 9 (01) ◽  
pp. 21-26
Author(s):  
Arif Budiman ◽  
Ayu Apriliani ◽  
Tazyinul Qoriah ◽  
Sandra Megantara
Keyword(s):  
Solvent Evaporation ◽  
Physical Mixture ◽  
Dissolution Profile ◽  
Solvent Evaporation Method ◽  
X Ray Diffraction ◽  
Scanning Calorimetry ◽  
Evaporation Method ◽  
Dissolution Properties ◽  
Mixture Characterization

Purpose: To develop glibenclamide-nicotinamide cocrystals with the solvent evaporation method and evaluate their solubility and dissolution properties. Methods: Cocrystals of glibenclamide-nicotinamide (1:2) were prepared with the solvent evaporation method. The prediction of interactive cocrystals was observed using in silico method. The solubility and dissolution were performed as evaluation of cocrystals. The cocrystals also were characterized by differential scanning calorimetry (DSC), infrared spectrophotometry, and powder X-ray diffraction (PXRD). Result: The solubility and dissolution profile of glibenclamide-nicotinamide cocrystal (1:2) increased significantly compared to pure glibenclamide as well as its physical mixture. Characterization of cocrystal glibenclamide-nicotinamide (1:2) including infrared Fourier transform, DSC, and PXRD, indicated the formation of a new solid crystal phase differing from glibenclamide and nicotinamide. Conclusion: The confirmation of cocrystal glibenclamide-nicotinamide (1:2) indicated the formation of new solid crystalline phases that differ from pure glibenclamide and its physical mixture

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