Preparation and Characterization of Folate-Targeted Chitosan Nanoparticles Loaded with Hydroxycamptothecin
2012 ◽
Vol 557-559
◽
pp. 434-437
Keyword(s):
X Ray
◽
FA-targeted and 10-hydroxycamptothecin loaded chitosan nanoparticles (FA-HCPT-NPs) were prepared with a combination of emulsion-solvent evaporation and chemical crosslink method. The analysis revealed that the FA-HCPT-NPs were spherical with diameter of 255.5 16.2 nm, zeta potential of + 70 mV, HCPT encapsulation efficiency of 81.2% and loading rate of 2.5%. X-ray powder diffraction illustrated that HCPT was buried as an amorphous form in the NPs. The release profiles of HCPT exhibited a biphasic pattern characterized by an initial burst release followed by a slower and sustained release. The results indicated that the novel FA-HCPT-NPs could be a potential drug delivery system for tumor cell-selective targeting therapy.
1981 ◽
Vol 219
(2)
◽
pp. C23-C25
◽
2012 ◽
Vol 465
◽
pp. 76-79
◽
2005 ◽
Vol 494
◽
pp. 351-356
◽
2021 ◽
Vol 26
(1(77))
◽
pp. 16-25
Keyword(s):