Investigation on the In Vitro Degradation and Release Behaviors of Calcium Phosphate Containing Chinese Medicine

2005 ◽  
Vol 284-286 ◽  
pp. 395-398 ◽  
Author(s):  
X.H. Yu ◽  
Shao Xing Qu ◽  
Y.R. Liu ◽  
R. Shen ◽  
Xiao Hong Li ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Calcium Phosphate ◽  
Salvia Miltiorrhiza ◽  
In Vitro Release ◽  
In Vitro Degradation ◽  
Vis Spectroscopy ◽  
Controllable Release ◽  
Before And After ◽  
Vitro Release

The purpose of this study was to investigate the in vitro degradation and release behaviors of calcium phosphate powders (Ca/P) containing Chinese Medicine for bone graft. Two kinds of Ca/P powders, one with the Chinese Medicine, Salvia Miltiorrhiza Bunge (SMB) and the other with Polyacrylic Acid (PAA) and SMB, were soaked in simulated body fluid (SBF) for up to 150h. The in vitro release of SMB was measured by UV-VIS spectroscopy. The Ca2+ concentrations and pH of SBF soaked Ca/P powders were measured by AAS and pH meter. TA and XRD were employed to analyze various Ca/P powders before and after soaked in SBF, respectively. The results demonstrated that a faster SMB release occurred during the first 24 hours, while a slow release was sustained up to150h. Furthermore, the released of SMB in Ca/P-PAA-SMB was faster than that of Ca/P-SMB. It was concluded that a controllable release of Chinese Medicine from Calcium phosphate may be carried out by the addition of suitable surfactant. Accordingly, calcium ions were released into SBF, which was benefit for bone tissue repairing and reconstructing. Additionally, the TA results showed that there was 1.66% SMB released from Ca/P-SMB-PAA powders. XRD confirmed that various Ca/P powders possessed poorer crystallinity and smaller grain size.

Self-Setting Calcium Phosphate Bone Cement Preparation, Characterization and Drug Delivery for Skeletal System

2017 ◽  
pp. 184-199
Author(s):  
Sayed Reza Shaffiey ◽  
Sayedeh Fatemeh Shaffiey
Keyword(s):  
Calcium Phosphate ◽  
Calcium Phosphates ◽  
In Vitro Release ◽  
Setting Times ◽  
Calcium Phosphate Bone Cement ◽  
Before And After ◽  
Vitro Release ◽  
Supersaturated Solutions ◽  
Cement Setting

The reactivity of acid base cements forming hydroxyapatite (HA) such as, ß-tricalcium phosphate (ß-TCP) and dicalcium phosphate dehydrate (DCPD). Amorphous calcium phosphates, prepared by precipitation from supersaturated solutions, can also react to form apatitic cements since they are thermodynamic unstable with respect to HA and have a setting reaction more independent of particle size. Calcium phosphate cement containing an antibiotic can be used for filling bone defects and to ensure local antibiotherapy. Therefore, in the present chapter proposal, cement paste was prepared by combining cement liquids comprised of Na2HPO4 with cement powders. Gentamicin sulfate was also loaded on the cements and its in vitro release was evaluated over a period of time. The cement setting times were compared before and after drug addition. According to results, the initial and final setting times of samples increase after drug addition.

Calcium phosphate porous pellets as drug delivery systems: Effect of drug carrier composition on drug loading and in vitro release

2012 ◽  
Vol 32 (11) ◽  
pp. 2679-2690 ◽  
Author(s):  
Hiva Baradari ◽  
Chantal Damia ◽  
Maggy Dutreih-Colas ◽  
Etienne Laborde ◽  
Nathalie Pécout ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Calcium Phosphate ◽  
Drug Delivery Systems ◽  
Drug Carrier ◽  
Drug Loading ◽  
In Vitro Release ◽  
Delivery Systems ◽  
Vitro Release

scholarly journals Evaluation of physicochemical and antioxidant properties of nanosized copolymeric micelles loaded with kaempferol

Pharmacia ◽  
2020 ◽  
Vol 67 (2) ◽  
pp. 49-54
Author(s):  
Krassimira Yoncheva ◽  
Nadia Hristova-Avakumova ◽  
Vera Hadjimitova ◽  
Trayko Traykov ◽  
Petar Petrov
Keyword(s):  
Antioxidant Activity ◽  
Propylene Oxide ◽  
Encapsulation Efficiency ◽  
Antioxidant Properties ◽  
In Vitro Release ◽  
Before And After ◽  
Poly Propylene ◽  
Vitro Release

The study was focused on the evaluation of two copolymers as micellar carriers for kaempferol delivery. The copolymers comprised identical hydrophilic blocks of poly(2-(dimethylamino)ethyl methacrylate and different hydrophobic blocks of either poly(ε-caprolactone) (PDMAEMA9-b-PCL70-b-PDMAEMA9) or poly(propylene oxide) (PDMAEMA13-b-PPO69-b-PDMAEMA13). The calculation of Flory-Huggins parameters and determination of encapsulation efficiency showed that PDMAEMA-b-PCL-b-PDMAEMA copolymer possessed higher capacity for kaempferol loading. The diameter of the micelles before and after lyophilization was not changed, suggesting that the micelles could be lyophilized and redispersed before administration. The in vitro release of kaempferol from PDMAEMA-b-PPO-b-PDMAEMA micelles was faster than the release from PDMAEMA-b-PCL-b-PDMAEMA micelles, probably due to the higher affinity of kaempferol to this copolymer. Further, the higher affinity resulted in a retention of antioxidant activity of kaempferol in the presence of DPPH and KO2 radicals. Thus, PDMAEMA-PCL-PDMAEMA was considered more appropriate carrier because of the higher encapsulation efficiency and preservation of antioxidant activity of the drug.

In Vitro Characterization of Calcium Phosphate Biomaterial Loaded with Linezolid for Osseous Bone Defect Implantation

2010 ◽  
Vol 26 (7) ◽  
pp. 811-828 ◽  
Author(s):  
Hélène Gautier ◽  
Adrien Plumecocq ◽  
Gilles Amador ◽  
Pierre Weiss ◽  
Christian Merle ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Mercury Porosimetry ◽  
In Vitro Release ◽  
Release Time ◽  
Wet Granulation ◽  
Gram Positive Bacteria ◽  
In Vitro Characterization ◽  
Vitro Release

Osteomyelitis is a severe bone infection frequently caused by Staphylococcus aureus, which shows significant resistance to methicillin. One therapeutic treatment would be to insert a bone substitute loaded to an antibiotic, which would enable the bone to be filled while the illness is being treated. Linezolid is an oxazolidinone antibiotic with a large spectrum of action. It is effective against most Gram-positive bacteria and displays a specific mode of action. The aim of this work was to study the association of linezolid with a calcium phosphate-deficient apatite matrix. Granules containing 10% and 50% linezolid were prepared by wet granulation and characterized. Porosity analyses performed by mercury porosimetry and scanning electron microscopy revealed that grain porosity with 50% linezolid was higher than that of the grains containing 10% linezolid. NMR analyses showed no change in structure of linezolid when linked to calcium-deficient apatite. These results were confirmed by studying the antibacterial activity of linezolid, which remained proportional to the quantity of loaded linezolid, proving that the antibiotic released was active. The in vitro release time varied from 9 days for granules containing 10% linezolid to 26 days for granules containing 50% linezolid.

scholarly journals PREPARATION AND EVALUATION OF CLARITHROMYCIN LOADED BISMUTH SULFIDE (Bi2S3) NANOPARTICLES UTILIZING NANOTECHNOLOGY AS A NOVEL DRUG DELIVERY SYSTEM

2017 ◽  
Vol 9 (9) ◽  
pp. 115 ◽  
Author(s):  
Mustafa R. Abdulbaqi
Keyword(s):  
Drug Delivery ◽  
Antibacterial Activity ◽  
In Vitro Release ◽  
Bismuth Sulfide ◽  
Particle Size Reduction ◽  
Before And After ◽  
Release Study ◽  
Novel Drug ◽  
Vitro Release

Objective: This study was designed to improve the solubility and biological activity of class II drug clarithromycin (CLA) by utilizing the nanotechnology as a novel drug delivery system.Methods: Bismuth sulfide (Bi2S3) nanoparticles were synthesized using chemical co-precipitation technique, while the loading of clarithromycin (CLA) with bismuth sulfide (Bi2S3) nanoparticles was achieved using incorporation method. The loading process, as well as particle size reduction, were evaluated using x-ray diffraction (XRD), furrier transformed infrared (FTIR) and atomic force microscopy (AFM). In vitro release study was performed using USP paddle apparatus type II in phosphate buffer solution pH 7.4. Disc diffusion method was the technique used to test the antibacterial activity of CLA before and after loading process.Results: Loading of CLA with Bi2S3 nanoparticles was accomplished successfully accompanied with particle size reduction within nano range as measured by AFM. In vitro release study showed a significant* increase in solubility and dissolution profile of CLA after loading process, which was also proven using XRD that indicate transformation from crystalline into more soluble amorphous structure. Susceptibility test displayed significant* potentiation of antibacterial activity at all tested concentrations against gram+ve bacteria Staphylococcus aureus and Bacillus subtilis after loading of CLA with Bi2S3 nanoparticles, while gram –ve bacteria E. coli showed no response for CLA before and after loading process.Conclusion: The solubility, as well as the antibacterial activity of CLA, were improved significantly* after preparation of nanotechnology based drug delivery system through the utilization of metal nanoparticles, Bi2S3, as nanocarriers for CLA.

Sign in / Sign up

Export Citation Format

Share Document